NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 29 for “"HSPG"”.

  1. Characterization of heparan sulfate proteoglycan receptor from a permanent rat liver cell line

    Guo, YuchuanUniversity of Illinois at Urbana-Champaign2011

    … the existence of a heparan sulfate proteoglycan (HSPG) specific receptor on the cell surface of rat liver cell (RLC), and to characterize the specificity of the ligand-receptor interaction, the properties of the receptor, and the importance of the receptor in HSPG metabolism.

    uiuc Repository record

  2. Characterization of Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) interaction with the Bovine Aortic Endothelial (BAE) cell surface: Examination of the Role of Heparan Sulfate Proteoglycans (HSPG)

    Parghi, NiravVirginia Tech1998

    … M. The role of heparan sulfate proteoglycans (HSPG) in the IGFBP-3 binding mechanism was also examined. It was seen that inactivation of the cell surface HSPGs with 75 mM sodium chlorate did not affect IGFBP-3 binding. Further, there have been reports of inhibition of IGFBP-3 binding by heparin …

    vt Repository record

  3. Cell surface interactions of Coxsackie A9 virus

    Ioannou, MarinaUniversity of Essex2018

    … heparan sulphate/heparin class of proteoglycans (HSPG). This thesis describes work designed to improve our understanding of the involvement of a) the RGD motif and more specifically the RGDX position in CAV9 infection, using a large panel of different RGDX variants and a number of cell lines not …

    essex Repository record

  4. Mechanotransduction Modulates the Effect of Mechanical Forces (Fluid Shear Stress and Cyclic Strain) on Embryonic Stem Cell Differentiation Toward Vascular Endothelial Cells

    Nikmanesh, MariaThe Graduate School and University Center of The City University of New York2017

    … component heparan sulfate proteoglycans (HSPG) mediate shear stress mechanotransduction in mature EC.</p> <p>In the first part of this study, we investigated whether cell surface HSPG play a role in shear stress modulation of ESC phenotype. Our result presents that shear stress enhanced …

    cuny-grad Repository record

  5. Analysis of Cellular Factors Involved in Adeno-Associated Virus Type 2 Entry

    Bess, Cameron Dale

    … of AAV requires heparan sulfate proteoglycan (HSPG) as well as two secondary receptors, fibroblast growth factor receptor and αv/5 β5/1 integrins. In this study, we follow the cellular modifications induced upon AAV binding and subsequent internalization into host cells. Earlier reports …

    rockefeller Repository record

  6. Molecular Basis of Adaptation of Enteroviruses to Different Cancer Cell Lines

    Baeshen, NaseebhUniversity of Essex2015

    … CVA9 also bind to heparan sulfate proteoglycans (HSPG). This thesis describes work designed to improve our understanding of CVA9 and echovirus cell/receptor tropism. Several echoviruses and CVA9 variants were tested in a panel of 9 cell lines. Distinct patterns of infection were seen, but did not …

    essex Repository record

  7. Correlation of Heparan Sulfate Proteoglycan Structure and Metabolism With the Regulation of Cell Division

    Fedarko, Neal StevenUniversity of Illinois at Urbana-Champaign2014

    Heparan sulfate proteoglycan (HSPG), a ubiquitous cell surface component in animal cells, is a complex, polyanionic macromolecule consisting of a core protein to which are attached several heparan sulfate (HS) chains. Growing and confluent cultures of a rat hepatocyte cell line were labeled with …

    uiuc Repository record

  8. The Regulation and Mechanism of Myelin Synthesis Involving Endogenous Steroid Hormones

    Chan, Jonah R.University of Illinois at Urbana-Champaign2015

    … associated heparan sulfate proteoglycans (HSPG), surface competition experiments were performed with heparin and the basic peptide encoded by exon 6. Heparin and the exon 6 peptide were both found to dramatically inhibit the initiation of myelin formation. While these results are still …

    uiuc Repository record

  9. Mechanisms of Molecular Chaperone Surface Binding and Endocytosis: Insights into the Molecular Basis for GRP94 Immune Function

    Jockheck-Clark, Angela Roberta2010

    … cell surface heparan sulfate proteoglycans (HSPGs) were identified as novel cell surface binding sites for GRP94.NTD on MEF cells. This conclusion was established using three distinct experimental approaches. GRP94.NTD surface binding was significantly decreased following heparin …

    duke Repository record

  10. Vascular Endothelial Growth Factor In Cortical Development

    Cain, Jacob Thomas

    … or absence of a heparin sulfate proteoglycan (HSPG) binding domain. Vegf isoforms with the full HSPG-binding domain are not diffusible in the microenvironment (Vegf188) without proteolytic cleavage, those with a partial HSPG-binding domain are partially diffusible (Vegf164), and those lacking …

    nodak Repository record

  11. Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans

    Au, Rebecca2027

    … target receptors. Heparin sulfate proteoglycans (HSPGs), such as LON-2 glypican and UNC-52 perlecan, are likely candidates for the ECM proteins that interact and guide sAPL-1. The disruption of APL-1 causes phenotypical changes, including in learning, reproduction, and memory; these defects are …

    cuny Repository record

  12. Heparan Sulfate Proteoglycans in Pancreatic Ductal Adenocarcinoma (PDAC)

    Theardy, Madelaine, <p>0000-0003-2560-775X</p>2027

    … identified a heparan sulfate proteoglycan (HSPG), Syndecan-1 (SDC1), as a key effector for pancreatic ductal adenocarcinoma (PDAC) progression whose surface expression is driven by KRAS*. By leveraging various PDAC models, we found that surface SDC1 expression was initially diminished upon …

    uthsc Repository record

  13. Design, Herstellungsoptimierung, Charakterisierung und Anwendung einer randomisierten, auf Adeno-assoziierten Viren exprimierten Peptidbank

    Kaul, Felix

    … natürlichen Rezeptor Heparansulfat-Proteoglykan (HSPG) beteiligt ist. Dadurch wird einerseits die Bindung an HSPG abgeschwächt, andererseits ein neuer Bindungstropismus geschaffen. Ziel dieser Arbeit war die Herstellung einer "AAV-Kollektion", in der jedes Virus an der Oberfläche ein anderes, in …

    freiburg-diss Repository record

  14. Metabolism of Heparan Sulfate Proteoglycan in Rat Hepatocyte Cell Line and Its Role for Regulation of Cell Growth

    Ishihara, MasayukiUniversity of Illinois at Urbana-Champaign2014

    … heparan sulfate proteoglycan (HSPG) was taken up by the cells and converted to free chains and about 10 percent of the internalized HS was transported into nucleus.

    uiuc Repository record

  15. Syndecan-4 regulates cell-surface trafficking and biological activity of transglutaminase-2

    Scarpellini, ANottingham Trent University2009

    … (Verderio et al., 2003). Hence HS proteoglycan (HSPG) could act as cell surface co-receptor for FNbound TG2 or contribute to the regulation of extracellular TG2 activity in cell adhesion and tissue repair.

    nott-trent Repository record

  16. The role of heparan sulfate proteoglycans and heparanase in the control of vascular remodeling

    Baker, Aaron BlairMassachusetts Institute of Technology2006

    … TGF-1l signaling was essential for load-induced HSPG production and sustained p38 MAPK and ERK activation.

    mit Repository record

  17. On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer.

    Welch, JohannaDepartment of Oncology, Clinical Sciences, Lund University2010

    … of cell surface heparan sulphate proteoglycans (HSPGs) by anti-HS antibodies inhibits the bioavailability of exogenous polyamines, and that combined targeting of polyamine biosynthesis by α-difluoromethylornithine (DFMO) and HSPG-dependent uptake by a HIV-1 trans-activator of transcription (TAT) …

    lund Repository record

  18. The Heparan Sulfate Proteoglycan Perlecan Regulates Axonal and Synaptic Stability

    Guss, Ellen JaneMassachusetts Institute of Technology2023

    Heparan sulfate proteoglycans (HSPGs) form essential components of the extracellular matrix (ECM) and basement membrane (BM) and have both structural and signaling roles. Perlecan is a secreted ECM-localized HSPG that contributes to tissue integrity and cell-cell communication. In this thesis, I …

    mit Repository record

  19. Interaction studies of the cellular prion protein

    Hundt, ChristophLudwig-Maximilians-Universität

    … addition, cell binding assays revealed a second HSPG-dependent binding domain leading to a comprehensive model of the PrP/LRP complex on the cell surface. The binding of heparan sulfates to the prion protein was investigated and binding domains located on the N-terminus of the prion protein were …

    lmu-germany Repository record

  20. Cryo-electron microscopy of HPV16 pseudovirions reveal changes in capsid conformation upon furin cleavage

    Marx, Melissa LaurenDepartment of Clinical Laboratory Sciences2021

    … via binding to heparan sulphate proteoglycans (HSPGs). Cleavage of L2 by a host protease, furin, is necessary for infection and is thought to facilitate a conformational change in the virus capsid. Furin cleavage may affect the ability of HPV to bind to sulphated glycoproteins and a HSPG …

    cape-town Repository record

Page 1 of 2