Global ETD Search
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Showing 1 to 20 of 105 for “"HSP90"”.
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An Hsp90 physical interactome
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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Hsp90 as a molecular target
Heat shock protein 90 (Hsp90), a highly conserved molecular chaperone, has been proposed to play a vital role in tumorigenesis. Hsp90 has two isoforms, of which Hsp90α is the major isoform of the Hsp90 complex and has an inducible expression profile. The molecular chaperone Hsp90α has been …
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Inhibition of Hsp90 in Streptomyces coelicolor
Inhibition of the chaperone protein Hsp90 in plants and insects has been found to result in drastic changes in phenotype. We investigated the effect of Hsp90 inhibition on the bacteria Streptomyces coelicolor. These changes were studied by growing S. coelicolor in the presence of Hsp90 inhibitors, …
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Characterisation of the plasmodium falciparum HSP70-HSP90 organising protein
… (PfHsp70-1; PF3D7_0818900) and P. falciparum Hsp90 (PfHsp90; PF3D7_0708400) are some of the major Hsps involved in the cytoprotection of the parasite and therefore pathogenesis of malaria. Hsp70 and Hsp90 are brought into close proximity by Hsp70-Hsp90 organising protein (Hop), allowing Hsp70 …
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Neuronal Protection by a Novel C-terminal Hsp90 Modulator
… studies was to characterize a novel, non-toxic Hsp90 modulator, KU-32, which protects primary cortical neurons against Aβ1-42, a toxic peptide found in AD brain. Pharmacokinetic studies indicated that KU-32 is blood brain barrier permeable and orally bioavailable. Using two AD mouse models, …
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Isolation and characterisation of an Hsp90 homologue from the resurrection plant Xerophyta viscosa
… degree of sequence identity with the ER-Iocated Hsp90 or Grp94 family of proteins (hereafter referred to as XVGrp94) and forms the basis of this work. The XVGrp94 eDNA was found to be truncated at the 5· terminus and a full length eDNA was isolated using SMART-RACE™ (§witching Mechanism gt 5' end …
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Evaluating the Therapeutic Effect of an Hsp90 Inhibitor in Mouse Models of Alzheimer’s Disease
… Strategies targeting heat shock protein 90 (Hsp90) inhibition have been widely investigated in the treatment of cancer for over two decades. Its application in the treatment of neurodegenerative diseases however, has emerged more recently in the last decade. The role of the Hsp90 chaperone in …
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Synthesis Of Substituted Pyrrolo[2,3-D]Pyrimidines As Microtubule-Binding Agents and HSP90 Inhibitors
… agents and heat shock protein 90 (HSP90) inhibitors as anticancer agents are briefly reviewed. The work in this dissertation is centered on the synthesis of substituted pyrrolo[2, 3-d]pyrimidines as potential anticancer agents that act via microtubule inhibition or HSP90 …
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Molecular Mechanisms by Which HSP90 Inhibition in the Spinal Cord Enhances Opioid Receptor Signaling
… Our lab has identified heat shock protein 90 (HSP90) as a key regulator of opioid signaling by demonstrating that when HSP90 is inhibited in spinal cord using 17-AAG, ERK MAPK signaling, and subsequent opioid anti-nociception is enhanced. Quantitative proteomic analysis on the spinal cords of …
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The Pursuit of Unshocking Hsp90 Inhibitors: Development of Gedunin and Cruentaren A as Chemical Leads
Abstract: The 90 kDa heat shock protein (Hsp90) is a molecular chaperone that is critical cellular survival and growth under both typical and stressful conditions. Hsp90 is responsible for the maturation and stability of more than 200 client proteins involved in a diverse assortment of cellular …
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Charakterisierung von Schlüsselproteinen der Signaltransduktion (EGF-R, c-erbB2, Hsp90) in humanen Tumorxenografts mittels Gewebemikroarray
… der Signaltransduktion (EGF-R, c-erbB2, Hsp90) wurden in dieser Arbeit untersucht. Überexpression dieser Proteine in Tumoren geht mit schlechter Prognose für die Patienten einher. EGF-R und c-erbB2 sind deshalb interessante Targets für neue molekulare Tumortherapien. Spezifische …
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Inhibition of Heat Shock Protein 90 Reduces Inflammatory Signal Transduction in Murine J774 Macrophage Cells and Lessens Disease in Autoimmune MRL/lpr Mice: What in vitro, in vivo, and in silico Models Reveal
Heat shock protein 90 (HSP90) is a molecular chaperone protein that protects proteins from degradation, repairs damaged proteins, and assists proteins in carrying out their functions. HSP90 has hundreds of clients, many of which are inflammatory signaling kinases. The mechanism by which HSP90 …
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The effects of acute high- and low-intensity exercise on Hsp70 and Hsp90 accumulation in rat skeletal myofibres and vasculature
… were immunofluorescently stained for Hsp70 and Hsp90. It was hypothesized that: 1) a greater abundance of Hsp70 and Hsp90 would be observed in BVs following HIEX, 2) due to earlier recruitment, larger BVs would have a more robust response than small BVs, 3) more myofibres surrounding BVs …
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Heat shock protein 90, a potential biomarker for type I diabetes: mechanisms of release from pancreatic beta cells
… have shown serum levels of the alpha cytoplasmic HSP90 isoform are elevated in newly diagnosed type I diabetic patients, thus distinguishing this protein as a potential biomarker for pre-clinical type I diabetes mellitus (TIDM). This phase of disease is known to be associated with various forms of …
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Amyotrophic Lateral Sclerosis: mechanism behind mutant SOD toxicity and improving current therapeutic strategies
… the molecular chaperone heat shock protein 90 (Hsp90) have limited neuroprotection in some models of motor neuron degeneration. However the direct effect of Hsp90 inhibition on motor neurons is unknown. Here we show that Hsp90 inhibition induced motor neuron death through activation of the P2X7 …
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The Cystic Fibrosis Transmembrane Conductance Regulator: Regulation by HSP-90
… relevant association exists between CFTR and Hsp90. In testing this hypothesis, (a) the association of CFTR and Hsp90 is confirmed via crosslinking and immunoprecipitation of CFTR from stably transfected HEK-293 cells, electrophoretic separation of cross-linked proteins, and protein …
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Dual Regulation of Telomerase Activity By HSF1 And Its Role in Prostate Cancer Progression
It has been shown that the key components of the hsp90 chaperone complex, including hsp90, p23, hsp70, hsp40, and HOP (p60), associate with telomerase; however, their specific roles in telomerase function and tumor progression have not yet been defined. HSF1, the primary mammalian heat shock …
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Discovery of heat shock protein90 inhibitors using structured-based virtual screening
… as symptomatic therapy. Heat Shock Protein (HSP90), is one of the molecular chaperones that plays a role in AD pathogenesis. HSP90’s main function is to regulate the heat shock factor-1 (HSF-1) transcription factor, which is the key regulator of the heat shock response. Inhibition of HSP90 …
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