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Showing 1 to 20 of 48 for “"HSCT"”.
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Variable-Complexity Approximations for Aerodynamic Parameters in Hsct Optimization
… variables for the High Speed Civil Transport (HSCT) configuration and performance design is presented. Response surface model methodology is used to fit quadratic polynomials to data gathered from a series of numerical analyses of different HSCT designs. Several techniques are employed to …
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A coarse-grained variable-complexity MDO paradigm for HSCT design
… of the design of a high speed civil transport (HSCT). This paradigm interleaves the disciplines at one level of complexity, and processes them hierarchically at another level of complexity, achieving parallelism within disciplines, rather than across disciplines. A master-slave paradigm manages …
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Variable-Complexity Response Surface Approximations For Wing Structural Weight in HSCT Design
… material weight of a High Speed Civil Transport (HSCT) is presented. Response surface methodology is used to fit a quadratic polynomial to data gathered from a series of structural optimizations. Several techniques are employed in order to minimize the number of required structural optimizations …
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Development of Approximations for HSCT Wing Bending Material Weight using Response Surface Methodology
… material weight of a High Speed Civil Transport (HSCT) is described. The weight function is based on HSCT configuration parameters. A response surface methodology is used to fit a quadratic polynomial to data gathered from a large number of structural optimizations. To reduce the time of …
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PATTERN OF INNATE IMMUNITY IN PATIENTS AFFECTED BY MYELODYSPLASTIC SYNDROME (MDS) EITHER BEFORE ANDAFTER HEMATOPOIETIC STEM CELL TRANSPLANT (HSCT)
… patients is hematopoietic stem cell transplant (HSCT), however, only a small portion of patients is eligible for it. The dysregulation and dysfunction of the immune system with the acquisition of an immunosuppressive signature are emerging as important characteristics in the prognosis and the …
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"It really kind of like cuts my existence into two": an interpretative phenomenological analysis of the experience of adults with sickle cell disease receiving curative Haematopoietic Stem Cell Transplantation (HSCT)
… Haematopoietic Stem Cell Transplantation (HSCT) is the only cure, and as of 2020, these have been funded for adults with SCD by the National Health Service (NHS) in England. Rationale: The provision of psychology support is deemed important for patients undergoing HSCT, as studies have …
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Treatment Outcomes in Children with Very High Risk Acute Lymphoblastic Leukemia Intended to Treat with Allogeneic Hematopoietic Stem Cell Transplantation
… hematopoietic stem cell transplantation (Allo-HSCT) was use to treat the patients with VHR ALL. We studied the clinical course and outcomes of children with VHR ALL intended treat with Allo-HSCT after chemotherapy. 16 children who were diagnosed as VHR ALL and were intended to treat Allo-HSCT …
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Structural optimization and its interaction with aerodynamic optimization for a high speed civil transport wing
… for the high speed civil transport design (HSCT). Variable-complexity analysis methods are used to reduce the computational expense. A finite element-model based structural optimization procedure with flexible loads is implemented to evaluate the wing bending material weight. Static …
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Separation and Further Characterization of Hematopoietic Cell Populations Based on Phenotypic and Biophysical Properties
… hematopoietic stem cell transplantation (HSCT), a potent graft-versus-leukemia (GvL) effect must be balanced against the concomitant risk of severe immunological response to non-malignant host cells; graft-versus-host-disease (GvHD). In case of recipient-donor tissue antigen disparity, …
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Implementing Aerodynamic Predictions from Computational Fluid Dynamics in Multidisciplinary Design Optimization of a High-Speed Civil Transport
… optimization of a High-Speed Civil Transport (HSCT) is presented. To achieve this goal, the method must alleviate the large computational burden associated with performing CFD analyses and reduce the numerical noise present in the analyses. This is accomplished through the use of response …
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Statistical Modeling of Simulation Errors and Their Reduction via Response Surface Techniques
… in design of a high-speed civil transport (HSCT) are investigated. First, discretization error from a supersonic panel code, WINGDES, is considered. Second, convergence error from a structural optimization procedure using GENESIS is considered along with the Rosenbrock test problem. A grid …
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Perfil clínico, epidemiológico e sobrevida dos transplantados com células-tronco hematopoéticas
Hematopoietic stem cell transplantation (HSCT) is used as a treatment strategy for a series of inherited or acquired malignant and non-malignant diseases, with the possibility of cure or increase in disease-free survival. The objective of this study was to characterize the clinical and …
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Cardiotoxicity In Hematologic Stem Cell Transplant: Keeping The Beat
… number of hematopoietic stem cell transplants (HSCT) performed in the U.S. and worldwide is increasing. Cardiac events have been well described in HSCT, and incidence and type of cardiac events have not changed over recent decades. This study adds to the body of evidence in describing incidence …
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Pediatric sequential organ failure assessment score in a congenital heart defect population
… a hematopoietic stem cell transplantation (HSCT). Dunn’s multiple comparisons tests were performed for the two CHD groups and the HSCT patients. An alpha value of 0.05 was also used for these tests. RESULTS: Parameters determined to be statistically significant between the cyanotic and …
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Role of Lymphocyte Populations Following Allogeneic Haematopoietic Stem Cell Transplantation // Роля на лимфоцитните популации след алогенна трансплантация на хемопоетични стволови клетки
… haematopoietic stem cell transplantation (allo-HSCT) is an established therapeutic approach for a range of malignant and benign haematological disorders. Despite significant advances in the field of transplantation medicine, this method remains associated with a number of complications – …
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Bilirubin Nanoparticle As An Anti-Inflammatory Therapy For Graft Versus Host Disease
… of hematopoietic stem cell transplant (HSCT). Myeloablative conditioning regimen, consisting of chemotherapy and/or radiation, given prior to HSCT can cause tissue damage. This non-specific tissue damage triggers cross-presentation of alloantigens to the donor immune cells, causing …
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Molecular therapy for mucopolysaccharidosis Type I
… by hematopoeitic stem cell transplantation (HSCT) once a proper donor cell source is identified. Following HSCT, many patients exhibit a reduced rate of neurological deterioration. However, the potential of HSCT to ameliorate central nervous system manifestations of disease is limited by the …
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Aircraft Multidisciplinary Design Optimization using Design of Experiments Theory and Response Surface Modeling Methods
… performance of high-speed civil transport (HSCT) aircraft configurations. The aerodynamic models created using the two methods outlined above are employed in HSCT optimization studies so that the detrimental effects of numerical noise are reduced or eliminated during optimization. Results …
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Multidisciplinary optimization of high-speed civil transport configurations using variable-complexity modeling
… is presented for the high-speed civil transport (HSCT). Methods to parameterize the wing shape, fuselage shape and nacelle placement are described. Variable-complexity design strategies are used to combine conceptual and preliminary-level design approaches, both to preserve interdisciplinary …
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A retrospective description of primary immunodeficiency diseases at Red Cross War Memorial Children's Hospital, Cape Town, South Africa, 1975 – 2017
… haematopoietic stem cell transplantation (HSCT) had successful outcomes. The 7th patient died 2 months post-HSCT from overwhelming infection. Although we could not account for the children lost to follow up during the study period, 53 (21.0%) deaths were confirmed. Conclusions. Several …
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