Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"HPV16"”.
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Small Molecule Inhibitors of HPV16 E6
<p>High-risk human papillomaviruses (HR-HPVs) cause nearly all cases of cervical cancer. HPV 16 E6, one of two viral oncogenes, protects cells from apoptosis by binding to and accelerating the degradation of several apoptotic proteins, including caspase 8 and p53. We proposed that blocking the …
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Anti-tumor Mechanisms of HPV16 E6*
… in vivo. To test this prediction, we injected HPV16+ SiHa and HPV16- C33A cervical cancer cells overexpressing E6* into nude mice and monitored tumor growth over several weeks while comparing them with control tumors lacking E6* overexpression. E6* was found to reduce growth in both SiHa- and …
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HPV16 E6* Induces Oxidative Stress and DNA Damage
<p>High risk types of Human Papillomavirus are the causative agents of virtually all cases of cervical cancer, 50-90% of other anogenital cancers and approximately 30% of oral and pharyngeal cancers. The high-risk types encode two viral oncogenes, E6 and E7, which work together to initiate cell …
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Investigation of HPV16-related genomic alterations in cervical squamous cell carcinoma
This study examined the effects of human papillomavirus genomic integration into the host genome on host gene expression in cervical squamous cell carcinoma (CSCC) tumors. The genomic analysis involved clinical and genomics data analysis using bioinformatics and statistical methods. The Cancer …
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The role of surfaceant protein A in immunity to HPV16 pseudovirus infection
… to determine whether SP-A and/or SP-D bind to HPV16 pseudovirions (HPV16- PsVs). SP-A was shown to bind to HPV16-PsVs as well as enhance viral uptake by RAW264.7 murine macrophages, while SP-D bound HPV16-PsVs weakly and had no effect on viral uptake. To confirm these observations and to assess …
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Cryo-electron microscopy of HPV16 pseudovirions reveal changes in capsid conformation upon furin cleavage
… directly visualize the conformation changes to HPV16 pseudovirions (HPV16 PsVs) resulting from cleavage of L2 by exogenous furin using cryoelectron microscopy (cryo-EM). At 5 Å resolution, we observed that furin-cleaved HPV16 PsVs capsids display widespread changes in the arrangement of …
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Characterisation of human surfactant protein A and recombinant human vimentin in their modulation of HPV16 pseudovirus infection
… been identified in our laboratory that modulate HPV16 pseudovirus (HPV16-PsVs) infection in vitro, namely surfactant protein A (SP-A) and recombinant human vimentin (rhVim). Previous work suggested SP-A mediated immune recognition of HPV since SP-A-coated HPV16- PsVs enhanced viral uptake by …
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The impact of the Human papillomavirus type 16 on non-coding RNAs in Head and Neck cancer
… subtype. The high-risk variant, HPV type 16 (HPV16), is the cause for 90% of all HPV related OPCs. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been shown to have dysregulated expression in OPC. The dysregulated expression on ncRNAs can lead to …
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Thema - 1. Herstellung von HPV-16 rekombinanten Pflanzenviren für die Produktion viraler Gene in Leguminosen : 2. Modulation einer HPV-16-DNA-Vakzine
… einem Pflanzen-Virus-Vektorsystem verschiedene HPV16 rekombinante Viren herzustellen. Als Träger der HPV16-Sequenzen wurde die RNA-2 des Cowpea Mosaic Virus verwendet. Ziel war die billige Herstellungsweise einer anti-HPV16-Vakzine in Pflanzen (Vigna unguiculata) im großen Maßstab. Zu diesem …
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Plant production of Gonococcal peptide vaccine, candidate peptide display with HPVs
… production for a dual vaccine against HPV16 and gonorrhea, utilizing N. benthamiana as the expression host. The vaccine design involves the incorporation of a gonorrhea peptide, mimicking the 2C7 epitope of the surface molecule LOS on gonorrhea, into the surface DE loop of HPV16 …
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Smad Proteins and theTgf-Beta Signaling Pathway During In Vitro Progression of Hpv16-Immortalized Human Keratinocytes' and 'Microarray Gene Expression Profiling of Exfoliated Cervical Cells'
… papillomavirus type 16 immortalized HKc (HKc/HPV16) are sensitive to the growth inhibitory effects of TGF-β, HKc/HPV16 gradually develop resistance to TGF-β as the cells progress in vitro to a differentiation resistant phenotype (HKc/DR). Previous studies in our laboratory have demonstrated …
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Mechanisms of human papillomavirus and host gene transcriptional deregulation in cervical carcinogenesis
… SCCs are caused by the deregulated expression of HPV16 oncogenes E6 and E7 in proliferating basal cells of the cervical squamous epithelium. The major risk factor associated with cervical neoplastic progression is integration of HRHPV into the host genome, which is detected in $~$85% of …
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Beteiligung der Gene E6 und E7 des Mastomys natalensis Papillomvirus an der Entstehung von Hauttumoren in transgenen Mäusen
… entspricht der des genitalen ‚high-risk' HPV16-E6-Proteins. In transgenen Mäusen, die ausschließlich mit einem Tumorinitiator oder einem Tumorpromotor behandelt wurden, entstanden keine Hauttumoren. Dies zeigt, daß das MnPV-E6-Protein eine Tumorinitiation oder Tumor-promotion nicht …
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Human Papillomavirus vaccination: Immunological and epidemiological studies
… of this epitope for overall immunogenicity of HPV16, we engineered HPV16 virus-like particles devoid of the H16.V5 epitope by site-directed mutagenesis of 10 non-conserved, surface exposed residues. Removal of the V5-defined epitope had only marginal effect on antigenic reactivity with …
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T-cell responses to human papillomavirus in men with anal high-grade squamous intraepithelial lesions
… are caused by human papilloma virus type 16 (HPV16) and is preceded by a precancerous stage termed high-grade squamous intraepithelial lesion (HSIL). Unlike cervical cancer, the natural history of anal HSIL is poorly understood, and there is little evidence to inform prevention guidelines. In …
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HPV and p16 in head and neck cancer
… nodal metastasis and T3 tumour size and smoking. HPV16 was predominantly present in female patients and was associated with an improved overall survival and recurrence free survival. p16 positivity varied from 76-78% in carcinomas, 51% in benign lesions and 66% in dysplasias. p16 status was not …
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Tsyn-Seq: A T Cell Synapse-Based Antigen Identification Platform
… derived from human papillomavirus type 16 (HPV16), Tsyn-seq successfully enriched the correct cognate antigen from a cDNA library derived from an HPV16-positive cervical cancer cell line. Tsyn-seq provides a method for rapidly identifying antigens recognized by TCRs of interest from a tumor …
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Characterisation of surfactant protein a as a novel prophylactic means against oncogenic HPV infections
… as a novel molecule capable of recognising HPV16 pseudovirions (HPV16-PsVs) with functional consequences for reduced infection in a murine cervicovaginal HPV challenge model. Building on these findings, our aim was to assess SP-A's suitability as a novel broad-spectrum HPV targeting molecule …
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Desarrollo de sistema lentiviral para la codificación de un short hairpin RNA que permite el silenciamiento dual de las oncoproteínas E6 y E7 de HPV16 en células de pulmón humano
… subgrupo de tumores de cabeza y cuello, siendo HPV16 el más prevalente. Este virus de alto riesgo neoplásico también ha sido detectado en tejido pulmonar tumoral, pero su rol etiológico en esta enfermedad es aún controversial. La oncogenicidad de HPV16 está mediada por la sobreexpresión de E6 y …
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ROLE OF THE MUCOSAE-ASSOCIATED EPITHELIAL CHEMOKINE (MEC/CCL28) IN THE MODULATION OF THE IMMUNE RESPONSE AGAINST VIRAL INFECTIONS
… against mucosal infections. HIV1IIIB-, H7N1- and HPV16-VLPs were produced in collaboration with the Ruhr-Bochum University, the University of Montpellier and the German Research Cancer Centre of Heidelbergh, respectively. Inbred female Balb/c mice were randomized to receive HIV1IIIB-VLPs or …
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