Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"HPLC/MS"”.
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Caratterizzazione mediante HPLC-MS di modifiche post-trasduzionali di proteine istoniche
… messo a punto un nuovo metodo cromatografico HPLC che ha consentito di ottenere una buona separazione, alla linea di base, delle otto classi istoniche (H1-1, H1-2, H2A-1, H2A-2, H2B, H3-1, H3-2 e H4). La separazione HPLC delle proteine istoniche ha permesso di poter eseguire analisi accurate …
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HPLC/MS mérési módszer alkalmazása települési szennyvizek, szennyvíziszapok és komposztok gyógyszermaradékainak meghatározására
Települési szennyvíz, és szennyvíziszap valamint komposzt gyógyszermaradékainak vizsgálata. Gyors módszert sikerült kidolgozni, mellyel 10 perc alatt meghatározhattuk a négy gyógyszerhatóanyagot (ibuprofen, ketoprofen, naproxen, diklofenák)
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Evaluation of selected aliphatic acids and polytetrahydrofurans for use as calibration agents for thermospray Hplc/Ms
A method of tuning and calibration for a thermospray ion source on a benchtop quadrupole mass spectrometer using trifluoroacetic acid, pentafluoropropionic acid, heptafluorobutyric acid, polytetrahydrofuran-250, and polytetrahydrofuran-650 was proposed and evaluated. A 0.5% solution of the …
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The Reconstruction of Climate in Beringia by analysis of Glycerol Dialkyl Glycerol Tetraether (GDGT) Distributions using High Performance Liquid Chromatography – Mass Spectrometry (HPLC-MS).
… ionisation to mass spectrometric detection (HPLC-APCI-MS). Glycerol dialkyl glycerol tetraether (GDGT) ratios within the extracts were used to reconstruct sea surface temperatures (SSTs), mean air temperatures (MATs) and pH. Climatic and environmental parameters were successfully assessed and …
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Die Aufklärung der Biogenese strukturell ungewöhnlicher Alkaloide aus Triphyophyllum (Dioncophyllaceae) und Antidesma (Euphorbiaceae) und Entwicklung und Einsatz der "Triade" zur phytochemischen Online-Analytik: HPLC-MS/MS, HPLC-NMR und HPLC-CD
… die methodische Verbesserung der online-"Triade" HPLC-MS/MS, HPLC-NMR und HPLC-CD im Vordergrund. Diese neuen Techniken dienten im Anschluß der phytochemischen Untersuchung verschiedener Pflanzenextrakte. Nach der erstmaligen online-Analyse von Ancistrocladus griffithii wurden drei neue Alkaloide, …
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Determination of nicotine and its metabolites by capillary electrophoresis and mass spectrometry.
… device for coupling with a mass spectrometer (MS). The overall aims of this work were to produce a sensitive, highly selective, and simple CE-sample stacking/MS assay for the measurement of nicotine and its metabolites in urine, to develop a highly sensitive transient isotachophoretic/MS …
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Passive in-situ estrogenic potency sampling with DGT-YES
… and synthetic estrogens in municipal water systems, as well as along the Waikato River. The concentration of these compounds was assessed using a novel combination of methods that allowed the actual levels of endocrine disruption to be ascertained. This was based on diffusive gradients in thin …
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Pilot study: identification of anthocyanin metabolites in the mice fed purple-fleshed sweetpotato
… were analyzed for anthocyanin metabolites using HPLC/MS and MALDI-TOF-MS. Fifteen hours after consumption of P40 diet, we identified 4 anthocyanin metabolites cyanidin 3,5- diglucoside; cyanidin 3-sophoroside-5-glucoside; cyanidin3-p-hydroxybenzoylsophroside-5-glucoside; and peonidin …
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Genetic analysis of agronomic and enological traits in grapevine
… during 2 growing seasons (2009 and2010)with HPLC-MS. Fifteen monoglucosideanthocyanins were detected with HPLC-MS, including two unidentified compounds. The concentration of 13 identified anthocyanins and the percentage of non acylated, acetyl and coumarylanthocyanins were analyzed to …
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Advanced analytical strategies to determine biomedical parameters for medical diagnostics, drug delivery, and therapy
… chromatography - tandem mass spectrometry (HPLC-MS/MS), and 3) nuclear magnetic resonance (NMR) studies of porous wall hollow glass microspheres (PWHGMs) that have the potential to be used as drug delivery carriers. Firstly, a dual-core fiber-optic pH micro-probe was developed which can be …
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Isolierung und Charakterisierung neuer Naturstoffe aus Schwamm-assoziierten Mikroorganismen
… mit der Hochdruckflüssigchromatographie (HPLC) gekoppelter spektroskopischer Methoden war es dabei möglich, bekannte Sekundärmetabolite frühzeitig zu erkennen und so die Suche nach neuen Naturstoffen besonders effizient zu gestalten. Dabei wurden neben den gängigen Verfahren HPLC-UV und …
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Carbon based secondary metabolites in African savanna woody species in relation to anti-herbivore defense
… polymers were determined by thiolysis using HPLC and HPLC-MS. Photosynthesis, growth variables andphenotypic phytochemical responses to the different N and N x herbivory treatments were measured in C. apiculatum. Low 7molecular weight phenolics were determined and identified using HPLC and …
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Stress and release : chemical modulation of secondary metabolite production in Aspergillus sp.
… in three species of Aspergillus. Diode array HPLC MS analysis of culture extracts revealed Aspergillus terreus demonstrated the most profound response, with upregulation of more then twelve compounds from three distinct chemical families; butyrolactones, aspulvinones, and asterriquinones. …
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Zuckerphosphate als Vorläufer von 4-Hydroxy-3(2H)-furanonen - Biochemische Transformation durch die Hefe Zygosaccharomyces rouxii und chemische Bildung unter physiologischen Bedingungen
… in denen der Einfluss verschiedener Wachstumsbedingungen auf die HDMF-Bildung durch Z. rouxii getestet wurde, zeigten bezüglich der HDMF-Bildung ein pH-Optimum bei pH 5.1 sowie eine maximale Produktivität der Zellen bei einer NaCl-Konzentration von 20%. Mittels einer neu entwickelten …
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Isolation and characterisation of toxins from Fibrocapsa japonica (Raphidophyceae)
Harmful Algal Blooms (HAB) is a natural disaster which has attracted global attention in recent decades since it threatens greatly public health, causes economic damage to fisheries and tourism. Fibrocapsa japonica is one of HAB causative organisms which caused significant loss to coastal fisheries …
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Trimethylation Enhancement using Diazomethane (TrEnDi) Enhances Mass Spectrometry-Based Analysis of Glufosinate and 3-(Methylphosphinico)propionic Acid in Complex Matrices
… liquid chromatography tandem mass spectrometry (HPLC-MS/MS), analyte retention and sensitivity are increased after derivatization, 6.7-fold for glufosinate and 6.3-fold for 3-MPPA. TrEnDi methodology was applied to canola samples from two separate fields sprayed with Liberty®. Prior to …
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‘Organics in ice’: Novel organic compounds in ice cores for use in palaeoclimate reconstruction
… which can be up to 50% organic. This thesis aims to develop the understanding and quantification of a number of these organic compounds in ice core samples. A novel and promising area of ‘organics in ice’ research lies within the groups of primary and secondary compounds released from the …
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β-Sitosterol Isolated from Theobroma Cocoa Induces the Expression Of Mkp-1 and Il-10 In Trigeminal Neurons
… was identified as β-sitosterol based on NMR and HPLC/MS/MS data. The anti-inflammatory mediators MKP-1 and IL-10 were up-regulated in trigeminal neurons in a concentration-dependent manner by β-sitosterol. A somewhat surprising finding from my study was that the active compound β-sitosterol …
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The Toxicokinetic Behavior of Cyanide, Thiocyanate and 2-Amino-2-Thiazoline-4-Carboxylic Acid Following Cyanide Exposure in Multiple Animal Models Utilizing Novel Methods of Detection
… gas-chromatography mass-spectrometry (CI-GC-MS) and high-performance liquid chromatography tandem mass-spectrometry (HPLC-MS-MS). The CI-GC-MS method produced limits of detection (LOD) of 1 μM and 50 nM with linear dynamic ranges of 10 μM-20 mM and 500 nM-200 μM for cyanide and thiocyanate, …
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Modifying Tryptophan and Indole-Derived Compounds Using Engineered Indole Prenyltransferase Enzymes
… (IPT) enzymes are present in many microorganisms. They catalyze the transfer of prenyl moieties from natural pyrophosphate donors to tryptophan and other indole-derived small molecules. Prenylation alters the structure of small molecules, enhances their hydrophobicity, and subsequently alters …
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