Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"HO-1"”.
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Rol de la hemoxigenasa 1 (HO-1) en cáncer colorrectal
La expresión de hemoxigenasa 1 (HO-1) ha demostrado estar sobre-regulada en el cáncer colorrectal (CCR), pero el papel que desempeña en este tipo de cáncer aún no se ha dilucidado. Los objetivos de este estudio han sido analizar la expresión de HO-1 en CCR invasivo humano, evaluar su correlación …
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Il sistema dell'Eme Ossigenasi-1 (HO-1) nel Glioblastoma Multiforme
… dei pazienti di 14-17 mesi. L'Eme Ossigenasi (HO) è l'enzima che limita la velocità nel catabolismo dell'eme: questa reazione enzimatica in due fasi provoca la formazione di quantità equimolari di biliverdina, ferro e monossido di carbonio (CO). HO esiste in due forme, HO-1, la forma …
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Estudio de la biología de HO-1 en el cáncer de tiroides
… el rol clave de la proteína hemoxigenasa-1 (HO-1) en la progresión de algunos tumores. Es por ello que hipotetizamos que también podría cumplir un rol en CT y que, incluso, podría utilizarse como marcador diagnóstico o de evolución de la enfermedad. Se organizó un grupo de trabajo con médicos …
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Einfluss von endogenem NO auf die Expression von HO-1 mRNA in der Rattenleber
Das HO/CO-System spielt eine entscheidende Rolle bei der Aufrechterhaltung der physiologischen Leberfunktionen sowie der Leberzellintegrität. NO besitzt ebenfalls hepato-protektive Eigenschaften. Zahlreiche Studien beschreiben eine Induktion der HO-1 Genexpression unter dem Einfluss von exogenem …
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A Novel Role for and Potential Therapeutic Targeting of Heme Oxygenase-1 in HIV Neuropathogenesis
… and oxidative stress. Heme oxygenase-1 (HO-1) is a highly inducible, detoxifying enzyme critical for limiting oxidative stress, inflammation, and cellular injury within the central nervous system (CNS) and other tissues. Our analysis of HO-1 expression in the brain prefrontal cortex from …
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Modulation of heme oxygenase-1 activity by novel synthetic compounds for pharmacological applications
In the past few years, heme oxygenase (HO) has been regarded as a potential pharmacological target, especially the inducible isoform, heme oxygenase-1 (HO-1). HO catalyzes the rate-limiting step of endogenous heme degradation, releasing carbon monoxide (CO), free iron (Fe2+), and biliverdin (BV), …
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Molecular mechanisms of the cytokine-dependent induction of the heme oxygenase-1 gene: in vivo and in vitro studies
Hämoxygenase-1 (HO-1) ist das Schlüsselenzym, das den Abbau von Häm zu Carbonmonixid (CO), zweiwertigem Eisen (Fe2+) und Biliverdin katalysiert. Wegen der facettenreichen anti-entzündlichen Wirkweisen dieser Produkte, wurde vorgeschlagen daß HO-1 in der Akuten-Phase Reaktion, der Abwehrreaktion des …
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Der Einfluss von Stickstoffmonoxid auf die schockinduzierte Hämoxygenase-1 Expression in der Leber der Ratte
… die hepatische Expression der Hämoxygenase-1 (HO-1) vor hepatozellulären Schäden nach hämorrhagischem Schock (HS) und Reperfusion schützen kann. Über die Regulation der HO-1 ist bisher nur wenig bekannt. In kultivierten Zellen in vitro konnte gezeigt werden, daß Stickstoffmonoxid (NO) die HO-1 …
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Induction of Heme Oxygenase By a Carbon Monoxide-Releasing Molecule
… and in pressure ulcers. Heme oxygenase has been shown to have important cytoprotective functions in myocardial ischemia-reperfusion injury and organ allograft survival. The cytoprotective effects of heme oxygenase are multifactorial. Besides reducing levels of pro-oxidant heme, heme oxygenase …
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Ifnγ Selectively induces Astrocyte Heme Oxygenase-1 Degradation: A Novel Proteasome Role in HIV Neuropathogenesis
… circulation and central nervous system (CNS). Pathological studies of post-mortem brain parenchyma indicate productive HIV replication in brain macrophages/microglia and restricted infection in some astrocytes, while analyses of cerebrospinal fluid (CSF) suggest infiltrating T lymphocytes as …
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Antioxidant pathways and human leukaemia chemotherapeutic sensitivity
… chronic myeloid leukaemia (CML) morbidity. However, acute myeloid leukaemia (AML) remains essentially incurable for the vast majority of patients. The current gold-standard treatment for AML has remained relatively unchanged for decades, consisting of the antimetabolite cytarabine (ara-C) …
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HOT study: the development, management and results from phase IIB, randomised controlled trial of heme arginate in recipients of deceased donor renal transplants
… renal transplantation. IRI increases the likelihood of delayed graft function (DGF), which negatively impacts on the long-term survival of a transplanted kidney. One enzyme of interest, heme oxygenase-1 (HO-1), degrades heme and protects against the oxidative stress that occurs secondary to IRI. …
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DIAGNOSI PRECOCE DEL DANNO DA ISCHEMIA RIPERFUSIONE E DELLA DISFUNZIONE RENALE POSTTRAPIANTO: RUOLO DELLA LIPOCALINA ASSOCIATA ALLA GELATINASI NEUTROFILA (NGAL)
… del suddetto organo. - l'utilità dell HO-1 sierico quale biomarker in grado di indicare il valore intrarenale dell HO-1 tenendo conto che l'incremento intrarenale dell HO-1 presenta specifiche correlazioni con l'insorgenza di danno renale acuto.
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Role of the macrophage in acute kidney injury
… of the innate immune system, with roles spanning host defence, cytotoxicity, clearance of apoptotic cells and promotion of tissue repair. Mφ are also known to be important mediators of renal injury in other experimental models of renal disease including transplantation, obstruction and …
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MicroRNAs as biomarkers of injury and drug response in renal transplantation
… with end stage renal disease. To meet the shortfall of organs available for transplantation, increasingly organs that have both endured and are more susceptible to ischaemia reperfusion injury (IRI), are being utilised for transplantation. As such, predicting and mitigating the impact of …
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Biological activity of anthocyanins and their phenolic degradation products and metabolites in human vascular endothelial cells
… significant vasoprotective activity of anthocyanins. However, few studies have investigated the activity of anthocyanin degradation products and metabolites which are likely to mediate bioactivity in vivo. The present thesis therefore examined the vascular bioactivity in vitro of …
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Role of the Haem Oxygenase Pathway in Protection against Vascular Dysfunction
… injury after ischaemic events is a well-known pathophysiological phenomenon. Enhanced oxidative stress by free radicals appears to be a major contributor to the ischaemic episode which can occur either by progression of a disease state (atherosclerosis or angina pectoris) or after surgical …
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Cellular uptake and actions of bilberry anthocyanins in retinal pigment epithelial cells
… stress play a significant role in the pathogenesis of age-related macular degeneration (AMD). In AMD, retinal pigment epithelium (RPE) cells are damaged by oxidative stress and die via the process of apoptosis. Anthocyanins from fruits and berries, such as bilberry (Vaccinium myrtillus), …
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Resistance to HER2-targeted therapies in HER2-positive breast cancer
… despite a trend towards lower HER2 expression. However, we found that treatment of cells with ERBB2 shRNA, the gene encoding HER2, increased levels of ZEB1 and enhanced migration, but did not induce overt EMT. This may be the result of differing PTEN status between in vivo and in vitro models. …
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Prevention of Ischemia-Reperfusion Injury in the Rat Liver by Atrial Natriuretic Peptide
… An early transcriptional induction of HO-1 by ANP independent of cGMP could be demonstrated. The induction of heme oxygenase-1 by ANP might not be responsible for the observed hepatoprotection, since inhibition of HO-1 activity did not abrogate the ANP effect. Interestingly, cell-type …
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