Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 328 for “"HLA"”.
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Der Einfluss von HLA-G und HLA-E auf Large Granular Lymphocytes
… die Chorionkarzinomzelllinien JEG-3 (exprimiert HLA-C und HLA-G) und JAR (MHC-Klasse I negativ, exprimiert HLA-E), zum anderen die Leukämiezellllinien K562 (untransfiziert), K562 (mit HLA-G transfiziert) und K562 (mit HLA-E transfiziert) als Modell für fetalen Trophoblasten verwendet. In …
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Strategien zur HLA-Typisierung mit PyrosequencingTM
… Region im humanen Genom. Die Untersuchung von HLA-Genorten stellt ein wichtiges Instrument in der molekulargenetischen Praxis dar. Die Pyrosequencing-Technik ist gut geeignet, um kurze DNA-Abschnitte mit weitgehend bekannter Sequenz schnell und effizient zu untersuchen. Ziel dieser Arbeit war …
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Einfluss von HLA-G und HLA-E exprimierenden K-562 Zellen auf in-vitro kultivierte humane dendritische Zellen
… des Trophoblasten exprimierten Moleküle HLA-G und HLA-E die Zytokinproduktion der DC modulieren. Material und Methoden. DC wurden aus isolierten Monozyten des peripheren Blutes kultiviert. Nach Inkubation mit Leukämiezellen der Linie K-562, an deren Oberfläche die HLA Moleküle der Klassen …
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Συσχέτιση των αντιγόνων ιστοσυμβατότητας (HLA) με την πέμφιγα
… FROM PEMPHIGUS FOLIACEUS. A TOTAL OF 61 ANTIGENS HLA-A,B,C,DR WAS DETERMINED AND THEIR RELATIONSHIP TO THE DISEASE WAS INVESTIGATED . 550 HEALTHY CONTROL GREEK PERSONS WERE USED 450 FOR THE LOCUS HLA-A AND HLA-B AND 100 FOR THE LOCUS HLA-DR. THE ANTIGEN DETERMINATION WAS PERFORMED BY MEANS OF THE …
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The role of HLA-G in bone marrow transplantation
The human leukocyte antigen-G (HLA-G has been considered to be an important tolerogeneic molecule playing an essential role in maternal-fetal tolerance, which constitutes the perfect example of successful physiological immunotolerance of semi-allografts. In this context, we investigated the …
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ΜΕΛΕΤΗ ΤΩΝ ΑΝΤΙΓΟΝΩΝ ΙΣΤΟΣΥΜΒΑΤΟΤΗΤΟΣ (HLA) ΣΤΟ ΣΥΝΔΡΟΜΟ ΑΔΑΜΑΝΤΙΑΔΗ-BEHCET
… PERSONS WERE TESTED FOR THE FREQUENCY OF 35 HLA ANTIGENS (HLA-A, B, DR). THE ANTIGENS DETERMINATION WAS PERFORMED BY MEANS OF TERASAKI'S LYMPHOCYTOTOXICITY TECHNIQUE. AN INCREASED INCIDENCE OF HLA-B5 ANTIGEN WAS FOUND (74% IN THE PATIENTS, COMPARED TO 30% IN THE HEALTHY CONTROL POPULATION). …
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The role of the HLA region in Hashimoto’s Thyroiditis
… The aims of this thesis were, i) to investigate HLA class II as a causal factor for Hashimoto’s thyroiditis ii) to investigate the potential role played by HLA class I MICA and MICB in Hashimoto’s thyroiditis. Several predisposing and protective loci within the HLA class II region were determined …
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Gyper: A graph-based HLA genotyper using aligned DNA sequences
… er hann kallaður human leukocyte antigen (HLA) og er staðsettur á styttri armi litnings 6. Vitneskja um hvaða genasamsætu einstaklingur hefur er mikilvægt fyrir svið læknisfræðinnar. Ýmsar leiðir eru til staðar sem geta til um tegund HLA genasamsætu einstaklings með hárri nákvæmni en þessar …
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Human Leukocyte Antigen (HLA) Associations and Gulf War Illness (GWI)
… Many studies show Human Leukocyte Antigen (HLA) associations with autoimmune, infectious, and inflammatory diseases. Researchers have hypothesized that the multi-symptom nature of GWI may share an autoimmune component. In order to test for a potential immunological component in GWI, we test …
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Tapasin - The star of the show in HLA-I maturation
Human leukocyte antigen class I (HLA-I) molecules are present on the cell surface of all nucleated cells. They bind intracellular peptides and present them to the immune system thus providing a readout to cytotoxic T-cells about the status of a cell. Maturation of the HLA-I molecule includes …
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Μελέτη των αντιγόνων ιστοσυμβατότητας (HLA) σε άτομα με γεωγραφική γλώσσα
… BETWEEN THE HISTOCOMPATIBILITY SYSTEM HLA AND GEOGRAPHIC TONGUE. THE HLA-A,B AND HLA-DR ANTIGENS WERE SEARCHED IN 50 UNRELATED PERSONS WITH GEOGRAPHIC TONGUE AND IN 380 HEALTHY CONTROL PERSONS, BY MEANS OF THE TERASAKI'S LYMPHOCYTOTOXICITY TECHNIQUE. AN INCREASED INCIDENCE OF DRW6, …
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Characterizing antigen-specific CD4⁺ T cells using HLA-DR oligomers
T cells are activated by the engagement of their surface T cell receptors (TCR) by antigenic peptide bound to major histocompatibility complex (MHC). The success or failure of this TCR to MHC-peptide interaction determines the specificity of T cell action, and thus plays a central role in proper …
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The HLA Complex Group 9 Gene Modification Study in Major Psychosis
… identified DNA modification differences at HLA complex group 9 (non-protein coding) gene (HCG9) in the post-mortem brain samples of individuals affected with schizophrenia (SCZ) and bipolar disorder (BPD). In this thesis we present results from bisulfite pyrosequencing based fine mapping of …
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Investigating the role of HLA class I derived peptide in alloreactivity.
… peptide complexed with human leukocyte antigen (HLA) can be said to have a significant role in the generation of alloresponses, both in terms of cellular and humoral alloresponses. Previous researchers have identified minor histocompatibility antigen (mHAG) derived peptides such as HA-1, and …
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The Immunopathogenesis of HLA B27-associated Spondylarthritis and Acute Anterior Uveitis
HLA-B27 is a Class I Major Histocompatability Molecule that is highly prevalent in patients with Acute Anterior Uveitis (AAU) and Seronegative Arthritis (SNA). Despite over 40 years of research, the pathogenic mechanism of HLA-B27-related disease remains elusive. The bacterium Chlamydia trachomatis …
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HLA-G, immunocompetent cells and pregnancy outcome: A case of modulation
Contains fulltext : 19242_hlagimcea.pdf (Publisher’s version ) (Open Access)
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Epigenetická regulace genů HLA II. třídy a jejich role u autoimunitních onemocnění.
… genetické riziko T1D je spojováno s geny HLA (lidské leukocytární antigeny) II. třídy. HLA II. třídy hrají klíčovou úlohu při regulaci imunitní odpovědi. Podílejí se na selekci T buněčného repertoáru v thymu a na prezentaci antigenních peptidů CD4+ T lymfocytům. Exprese genů HLA II. třídy …
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Development and Characterization of A Bi-Specific Antibody Targeting Hla-A2/Pr1
… strategy targeting myeloid leukemia antigen, HLA-A2 restricted peptide PR1.Previously, we have conducted pre-clinical development and humanization of a T cell receptor-like monoclonal antibody (h8F4) that targets PR1/HLA-A2 and eliminates AML xenografts by antibody-dependent cellular …
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