Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"HGG"”.
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Characterisation of genetic and epigenetic aberrations in paediatric high grade glioma
Paediatric high grade glioma (HGG), including diffuse intrinsic pontine glioma (DIPG) are highly aggressive tumours with no effective cures. Lack of understanding of the molecular biology of these tumours, in part due to lack of well-characterised pre-clinical models, is a great challenge in the …
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Humoral and cell-mediated immunity in vitamin A-deficient lambs
… antigenic challenges of human gamma globulin (HGG) (.1mg). In Trial II Con and A-def wether lambs were given primary and secondary antigenic challenges of ovalbumin (20μg). Half of the A-def lambs were then repleted with vitamin A. All lambs were subsequently given a primary and secondary …
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Studies of the idiotypic network through the use of a novel hemolytic plaque assay
… T independent. The murine immune response to DNP-HGG demonstrated a peak Ab2 PFC response which followed the peak Ab1 PFC response after both primary and secondary immunization. This Ab2 response was determined to be T dependent. The secondary responses to both DNP-Ficoll and DNP-HGG showed …
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Isolierung und strukturelle Charakterisierung von E-Selektin-bindenden Gangliosiden aus humanen Granulozyten
… Präparation humaner Granulozyten zur Verfügung (HGG-Fraktionen). Die Fraktion mit den als kurzkettig bezeichneten Gangliosiden enthielt hauptsächlich die Ganglioside GM3, IV3Neu5Ac-nLc4,IV6Neu5Ac-nLc4 und VI3Neu5Ac-nLc6. Die weiteren Fraktionen bestanden aus komplexen Gemischen von fukosylierten …
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Novel Oncogenic Drivers in Pediatric Gliomagenesis
<p>Pediatric high-grade gliomas (pHGGs), with a two-year survival rate of less than 20%, are some of the most aggressive human cancers. This dissertation begins with our analysis of 127 pHGGs, including brainstem (BS) and non-brainstem (NBS) tumors, from 118 patients using next-generation …
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Optimisation of Co-Firing of High Moisture Biomass with Coal in a Bubbling Fluidised Bed Combustor
… of coal fired fluidised bed hot gas generator (HGG) at the Cantley factory of British Sugar. It covers combustion of coal and biomass and their blends also called co-firing in a fluidised bed combustor. Particularly it focuses on the effect of introduction of moisture as part of fuel or …
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Genomic Instability and the Oncohistone H3K27M Drive Gliomagenesis in a Murine Model
… inhibition result in distinct high-grade glioma (HGG) formation resulting from elevated genome instability by DNA damage accumulation during embryogenesis. Furthermore, the presence of the oncohistone H3K27M mutation, commonly found in pediatric HGGs, enhances genome instability and accelerates …
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Genome-scale Precision Proteomics Identifies Cancer Signaling Networks and Therapeutic Vulnerabilities
… cancer proteome analyses on high grade gliomas (HGG) and rhabdomyosarcomas (RMS). Using systems biology approaches, we demonstrated that these newly developed proteomic analysis pipelines are able to (i) define human proteotypes that link oncogenotypes to cancer phenotypes in HGG and to (ii) …
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Molecular and Mechanical Heterogeneity in Adult and Paediatric High-Grade Glioma
… Both adult and paediatric high-grade gliomas (HGGs) are characterized by rapid proliferation and diffuse invasion of tumour cells into the surrounding stroma. Additionally, these tumours display a high degree of heterogeneity among patients, as well as within individual patients’ tumours, …
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Pre-operative Functional Magnetic Resonance Imaging: Application to Tumour Resection by Awake Craniotomy
… controls, but poorer in high-grade glioma (HGG) patients. More reliable activation patterns are demonstrated for motor tasks than for language tasks. The third project explores “Sources of variation influencing concordance between functional MRI and direct cortical stimulation in …
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Modeling of Cns Cancer With A Focus On The Immune Component
… in samples derived from human high-grade glioma (HGG) compared to those derived from low grade glioma (LGG). Overall, our data demonstrate that our implanted and spontaneous QPP models recapitulate the immunosuppressive myeloid dominant nature of the tumor microenvironment of human gliomas. Our …