Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Gli1"”.
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Investigation of the role of Glil+ cells in retinal angiogenesis and fibrosis.
… the Hedgehog pathway transcription factor, Gli1, in the development of fibrosis in numerous organs. This study aims to characterise Gli1 expression in ocular tissues and to elucidate the role of Gli1 in the development of fibrovascular membranes in the retina utilising transgenic mice, and …
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T cell receptor- and calcium-induced Gli signalling in CD8+ T cell effector function
… data from our laboratory demonstrated that Gli1, an important downstream Hh transcription factor, is important for the cytotoxic ability of murine CTLs in vitro and revealed that L-type voltage-gated Ca2+ channels (Cav1) are crucial for Gli1 induction. However, the role of Gli1 in the …
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Lineage specification of ovarian theca cells requires multi-cellular interactions via oocyte and granulosa cells
… Wt1-positive cells indigenous to the ovary and Gli1-positive mesenchymal cells that migrate from the mesonephros. These two theca progenitor populations are distinct in their cell lineage contributions, relative proximity to granulosa cells, and their gene expression profiles. The two sources of …
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Sonic hedgehog signaling pathway in normal and adenomatous pituitary
… Ptc2 and the Shh induced transcription factor Gli1, being so Shh-producing and Shh-responsive cells. Shh acts in an autocrine way inside corticotrophs, inducing a major stimulation of ACTH secretion in the normal rat pituitary and in the AtT-20 cell line. The Shh induced ACTH secretion effect …
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Targeting tGLI1-positive Breast Cancer with Ketoconazole
… variant of glioma-associated oncogene homolog 1 (GLI1) in glioblastoma (GBM), termed truncated GLI1 (tGLI1), that is a gain-of-function GLI1 transcription factor and demonstrates tumor-specific expression. Previous results in our laboratory have implicated tGLI1 in promoting breast cancer stem …
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Development and characterisation of a novel chimeric antigen receptor against LGR5
… of the Hh ligand Ihh and Hh transcription factor Gli1 in a series of in vitro cytokine polarisation assays, in vivo homeostatic proliferation models and antigen-driven memory formation and rechallenge influenza A virus infection models. Across all systems tested, loss of Ihh or Gli1 in T cells had …
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A Nonribosomal Peptide Pheromone Controls Male-Induced Female Sexual Development in Schistosoma mansoni
… In this study, a master transcription regulator (GLI1), a nonribosomal peptide synthetase (SmNRPS) and a pheromone metabolite β-alanyl-tryptamine (BATT) were discovered to firstly demonstrate the way a male parasite might signal his paired female. Using RNA sequencing, biochemistry assays and …
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Ο ρόλος του σηματοδοτικού μονοπατιού Sonic Hedgehog στον καρκίνο του πνεύμονα
… μελέτη της έκφρασης των μορίων Shh, Ptch1, Smo, Gli1, Gli2 και FoxM1. Τα αποτελέσματα αποκάλυψαν μια έντονη έκφραση των μορίων του μονοπατιού και αυξημένα ποσοστά ενεργοποίησής του. Επίσης βρέθηκε στατιστικά σημαντική συσχέτιση με τα πλακώδη καρκινώματα και με τα χαμηλού grade καρκινώματα. …
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Signaling crosstalk in cancers
… inhibits GLI transcriptional activity and GLI1 expression, and promotes GLI1 protein degradation in pancreatic cancer cell lines with activating KRAS mutation. Furthermore, Suppressing Gli activity leads to a selective attenuation of the oncogenic transformation activity of mutant …
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Dissecting the Role of Hedgehog Pathway in Murine Gonadal Development
… induce FLC development. My data showed that both GLI1 and GLI2 were modulators of Hh to establish FLCs. In chapter V, I addressed the third question on the possible role of GLI3 (as a transcriptional repressor) to silence the Hh pathway in the fetal ovary, which expresses other mammalian Hh genes, …
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The role of Hedgehog signalling in T cell effector function
… TCR to induce activation of transcription factor Gli1 to control CD8+ T cell killing. This is in contrast to the canonical Hh signalling pathway, which this thesis shows to be important in regulating CD4+ T helper cell polarisation. Using conditional knockout mouse models and clinically-approved …
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FSP1/S100A4-expressing stem/progenitor cells are essential for TMJ growth and homeostasis
… muiden oletettujen kantasolumarkkereiden, GLI1 ja Scleraxis, kanssa. BrdU Pulse Chase -kokeet osoittivat FSP1-syyruston osajoukon säilyttävän merkkiaineen, mikä viittaa FSP1:n leimaavan uuden kanta- ja esisolupopulaation kondyylissä. FSP1:tä ilmentävien solujen tuhoaminen ehdollisen …
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Regulation of morphogen signalling during neural patterning in the Xenopus embryo
… activates Hh signalling upon overexpression of Gli1, and Gli inhibits Wnt signalling upon overexpression of β-catenin. A biphasic model for the role of XSufu in anteroposterior patterning of the neural plate is presented suggesting that XSufu suppresses anterior Gli and posterior β-catenin …
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Funktionsanalyse des Irx1-Gens
… Regulationspartner untersucht. Die Analyse der Gli1- und Gli2-Mausmutanten konnte eine Interaktion mit Irx1 zeigen, was auf eine konservierte Regulatorfunktion hindeutet. Die in vitro-Analyse eines potentiellen Zielgens von Irx1 ergab, daß keine Aktivierung des Mash1-Promotors vorliegt. Die …
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Astrocytic Sonic Hedgehog signalling in development and disease
… between deep-layer Shh-positive neurons, Gli1-positive astrocytes, and neighbouring microglia in the post-natal cortex. Shh signalling is known to promote synaptic pruning, but the precise intercellular interactions involved in this process remain incompletely understood. With colleagues, …
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Comunicazione intercellulare e riprogrammazione del microambiente tumorale nella risposta patofisiologia del glioblastoma alla radioterapia
L’insorgenza e la progressione del glioblastoma (GBM) è supportata da un ampio range di fattori che influenzano lo stato metabolico, il setting genetico ed epigenetico del tumore e l’interazione con il microambiente circostante. Il complesso interplay tra cellule tumorali e microambiente innesca …