Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 350 for “"Genetic factors"”.
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Genetic factors in statin intolerance
… statin intolerance in order to study associated genetic factors.<br/><b><br/>Methods</b>: Prescribing trends such as switching or discontinuation of statin therapy were examined, and thresholds created to select true cases of intolerance. Information on CK levels was gathered from medical records …
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Mapping Major Genetic Factors of Obesity
… of obesity is a result of many different factors, all of which have a base in genetics and can be inherited through generations. Among these factors are eight cell-signaling molecules (adiponectin, leptin, resistin, tumor necrosis factor alpha, plasminogen activator inhibitor one, …
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Genetic factors associated with neuropathic pain
… NP is multifactorial, with evidence of both genetic and environmental factors contributing to its development. Although the genetic contribution to NP susceptibility has been recognised in recent decades, the underlying mechanism remains elusive. The aim of this research was to identify …
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Identifying Genetic Factors of BSE Susceptibility
… playing a role in BSE susceptibility in cattle, genetic analysis was carried out on cattle that were experimentally-infected with BSE and showed variable disease outcomes. Chapter 2 explores potential genetic reasons for an abnormal outcome following oral BSE challenge. This analysis found that …
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Genetic factors in human neural tube defects.
Contains fulltext : 145592.pdf (Publisher’s version ) (Open Access)
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INVESTIGATION OF GENETIC FACTORS DETERMINING ISCHEMIC STROKE OUTCOME
… and polygenic disorder. Most current genetic studies of ischemic stroke focus on genetic susceptibility rather than factors determining stroke outcome. The genetic components of ischemic stroke outcome are difficult to study in humans due to environmental factors and medical …
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Metabolic and genetic factors guiding hematopoietic cell fate
… states. Understanding the environmental factors that interplay with gene expression networks to regulate cell state holds immense potential for both basic scientific understanding and therapeutic advancements to treat cancer and other diseases. Of particular interest is the role of …
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Genetic factors that determine host resistance to bacterial infection
Antibiotic resistance is one of the major challenges that we face today. Not only in a medical sense, but also for a country’s national security, as the use of a bioweapon is an ever increasing concern. To help combat these threats, understanding how bacteria interact with their host could be a key …
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The role of genetic factors in breast cancer aetiology
… in women. There are several known risk factors for breast cancer including genetic<br/>factors which account for at least 25% of the incidence of breast cancer, although only a small<br/>proportion of this is a result of mutations in known high penetrance susceptibility genes. …
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Genetic factors involved with increased anthocyanin production in maize
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-04-06 without embargo terms
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Investigation of some infectious and genetic factors involved in cervical cancer
… was conducted to investigate infectious and genetic factors that may be involved in cervical cancer in Vietnam. The study comprises two parts: the first part examines the relationship between HPV and Chlamydia trachomatis infections and cervical cancer, and the second part focuses on the …
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Genetic factors affecting the RNA interference pathway of Aedes aegypti mosquitoes
… in studies involving mosquito innate immunity, genetics-based vector control strategies, and the development of viral-resistant transgenic mosquitoes. In general, RNA interference is induced by double stranded RNA (dsRNA) and results in the inhibition of cognate gene expression. There are …
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An investigation of genetic factors impacting sterol profiles in Australian olive oils
… individual cultivars, strongly implicating genetic factors as the cause of these different levels. The plant sterol biosynthetic pathway contains a bifurcation that leads to the formation of β-sitosterol or campesterol, with the flux controlled by the activity of two enzymes, …
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The Physiological and Genetic Factors Underpinning the Response to Muscle Damaging Exercise
… thesis was to investigate the physiological and genetic factors underpinning the response to muscle damaging exercise. For that, the following objectives were (i) to comprehensively assess the physiological mechanisms and recovery pattern of neuromuscular fatigue of the hamstring muscle group …
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The Physiological and Genetic Factors Underpinning Powerful Actions in Elite Youth Soccer
… soccer and, if it is, the physiological and genetic determinants of soccer-associated power remain unknown. Such information could be used to optimise soccer-specific talent identification and development strategies. With this in mind, the overriding aim of our thesis was to investigate the …
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Environmental and Genetic Factors Affecting Bone Diseases and Phenotypes in Mouse Models
… ways. We focused on studying the effects of genetic and environmental factors, especially their impact on bone properties. Firstly, we investigated the effects of β-caryophyllene (BCP), a naturally occurring dietary cannabinoid, on protecting bone from vitamin D deficiency in mice fed on a …
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Impact of environmental and genetic factors on pain sensitivity and chronic pain development
… examines the influence of environmental and genetic factors on pain sensitivity and chronic pain development. Chemotherapy-induced neuropathic pain (CIPN) is a common and debilitating side effect of chemotherapy treatment. However not all patients develop CIPN, and for those that do, severity …
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Genetic factors associated with performance and exercise-associated weight loss in Ironman triathletes
… participation in a 226 km Ironman triathlon. A genetic association approach was used in case-control studies to identify specific sequence variants within selected candidate genes. These candidate genes (IL-6, 5-HTT and MAO-A) were selected based on the biological function of their encoded …
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Examination of molecular genetic factors involved in sensitivity to breast cancer following radiation exposure
… since cancer most likely occurs from genetic damage that occurs over one's lifetime. DNA repair needs to be accurate and efficient in order for a cell to maintain genomic stability, and defects in repair systems can result in radiosensitivity. Because radiation exposure, DNA repair …
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