Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 323 for “"Gene Transcription"”.
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Mechanisms of Specificity in Neuronal Activity-regulated Gene Transcription
… to depend on the neuronal activity-regulated transcription of new gene products. My dissertation research sought to elucidate how the timing and level of transcriptional responses following neuronal activity can be precisely regulated to form proper neuronal connections. In the first part of …
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Genome Instability Associated with DNA Topoisomerase Activity during Gene Transcription
… pueden volverse irreversibles y provocar DSBs generando inestabilidad genómica e incluso la muerte celular. Al comienzo de esta tesis, los mecanismos que permitían a las células eucariotas reparar estas DSBs eran prácticamente desconocidos. Esta es una pregunta importante ya que las DSBs …
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Serum response factor-dependent regulation of smooth muscle gene transcription
… function of smooth muscle cells. During the pathogenesis of these diseases, smooth muscle cells have a marked alteration in the expression of many smooth muscle-specific genes and smooth muscle cells undergo a phenotypic switch from the contractile/differentiated status to the …
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Effective interactions arising from resource limitations in gene transcription networks/
Protein production in gene transcription networks relies on the availability of resources necessary for transcription and translation, such as RNA polymerase (RNAP) and ribosomes, which are found in cells in limited amounts. As various genes in a network compete for a common pool of resources, a …
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Towards characterisation of histone H1 gene transcription factors / by Blair Hopwood.
Bibliography : leaves 165-178.
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The Role of Gene Transcription and Inflammatory Cytokines in Bone Fracture Repair
… the first aim of the dissertation, we examined gene expression in response to injury across a broad range of time points for both intramembranous and endochondral bone formation. We used RNA sequencing to observe gene expression and immunohistochemistry to observe select protein expression …
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Mechanism of Human Papillomavirus E6-Mediated Repression of P53-Target Gene *Transcription
… by DNA tumor viruses to inhibit p53-dependent transcription is poorly understood. Here we describe a new paradigm for human papillomavirus (HPV) E6 oncoprotein-mediated repression of human p21 WAF1 cyclin-dependent kinase inhibitor gene transcription, independent of its well known role to …
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Estrogen Regulates Vitellogenin Gene Transcription and Messenger-Rna Degradation in Xenopus Laevis Liver
Vitellogenin gene transcription and mRNA degradation rates were measured in Xenopus laevis liver using pulse labeling and pulse chase techniques. Estrogen regulates the accumulation of vitellogenin mRNA through three processes: (1) There is a selective transcriptional activation of the vitellogenin …
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The effect of non-coding variants on gene transcription in human blood cell types
To understand complex genetic diseases it is necessary to study DNA, its transcription, translation and regulation thereof. In a mechanistic view diseases can be caused by alterations in the DNA sequence or by dysregulation of gene expression. To understand cell regulation, first connections have …
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Evidence for continuous potential for gene transcription during the cell cycle of a eukaryote
… the potential expression of the structural gene for isocitrate lyase (three D<sub>S</sub>-Isocitrate glyoxylate-lyase, EC 4.1.3.1) during the cell cycle. Synthesis of the enzyme could be induced by placing cultures in the dark on acetate, with the induction process occurring in a quadratic …
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Signaling Specificity in a Campylobacter jejuni Two-Component System to Mediate Proper Flagellar Gene Transcription
… to result in disease. Expression of flagellar genes is regulated by alternative σ factors, whose activities are controlled by a regulatory cascade. Previous genetic screens discovered the flagellar type III secretion system (T3SS), the FlgSR two-component regulatory system (TCS), and the FlhF …
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Progesterone Regulation of Insulin like-Growth Factor : Binding Protein-5 Gene Transcription in Human Osteoblasts
… nuclear run-on analyses, PG increased IGF)3P-5 gene transcription to 400% of control. To define the underlying mechanisms, the human IGF13P-5 gene proximal promoter was cloned and sequenced. The proximal 500 bp of this region contains TATA and CAAT boxes, five putative PG response element (PRE) …
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ORGANIZATION AND FUNCTION OF SIMIAN VIRUS 40 ORIGIN REGION SEQUENCES IN LATE GENE TRANSCRIPTION AND REPLICATION.
… SIMIAN VIRUS 40 ORIGIN REGION SEQUENCES IN LATE GENE TRANSCRIPTION AND REPLICATION.
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The Arabidopsis C/S1 bacic leucine Zipper transcription factor network:Impact of heterodimer formation on target gene transcription
… eine wichtige Rolle bei der Regulierung der Genexpression. Zur Analyse der Heterodimerisierung der Arabidopsis thaliana (At) bZIP-Faktoren wurde ein Gateway® basierendes two-hybrid System in pflanzlichen Protoplasten etabliert und mit den Daten aus dem klassischen Hefe two-hybrid (Y2H) …
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A Role for Glycogen Synthase Kinase 3 beta in the Regulation of Glucagon Gene Transcription by Insulin
Insulin reguliert über seine Bindung an den Insulin Rezeptor in a-Zellen des endokrinen Pankreas eine Signalkaskade, die in einer Hemmung der Glucagongen-Transkription resulitert. In der vorliegenden Promotionsarbeit wurde dieser bis jetzt nicht vollständig aufgeklärte Mechanismus in Hinblick auf …
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