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Showing 1 to 20 of 34 for “"Gabapentin"”.
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Gabapentin Discriminative Stimulus Effects
<p>Gabapentin (Neurontin®), an anticonvulsant drug, is primarily prescribed for neuropathic pain and epileptic seizures. Gabapentin is an inhibitor of the voltage gated calcium channel (VGCC) subunit α<sub>2</sub>δ-1. Due to its unique binding site, gabapentin is widely thought to have low abuse …
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Discriminative Stimulus Effects of Gabapentin
… stimulus effects of the anticonvulsant gabapentin in rats trained to discriminate 30.0 mg/kg gabapentin from vehicle in a two-lever drug discrimination task. All of the ten rats tested were able to establish gabapentin as an interoceptive cue. Gabapentin produced full generalization (≥ …
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The trends and rates of gabapentin and pregabalin
<b>Background</b>: Gabapentinoids were initially introduced for the treatment of epilepsy, then became more widely used in neurology, psychiatry and primary healthcare for the treatment of neuropathic pain. However, gabapentinoids have frequent and debilitating side effects, including viral …
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Única dosis de gabapentin preoperatorio para analgesia postoperatoria: revisión de literatura
… en los últimos años se ha propuesto el Gabapentin preoperatorio como una buena opción paraanalgesia postoperatoria sin efectos secundarios. Metodología: se realizó una revisión sistemática incluyendo ensayos clínicos controlados realizados en pacientes adultos sometidos a diferentes …
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Das Antiepileptikum Gabapentin (Neurontin) als Agonist an ATP-sensitiven Kalium-Kanälen
… Wirkmechanismus des <br>neuen Antiepileptikums Gabapentin (Neurontin) zu untersuchen. Gabapentin zeigte klinisch deutliche antikonvulsive Eigenschaften und wurde anfangs als Zusatzmedikation bei pharmakoresistenten partiellen Epilepsien eingesetzt. Inzwischen wurde vorgeschlagen, Gabapentin bei …
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Association of incident gabapentin use: with long-term use of opioids, benzodiazepines and Z-drugs
Gabapentin was originally approved for treatment of seizures in patients with epilepsy and has also been used for neuropathic and inflammatory pain. In addition, off-label use has increased for various disorders, including mental disorders, such as anxiety disorders and bipolar disorders as well as …
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Freisetzung von zytoplasmatischem GABA ([3H]-GABA) und Glutamat (D-[3H]-Aspartat) durch Transporterumkehr (Heteroexchange) im Striatum von Ratte und Kaninchen
… den zytoplasmatischen Freisetzungsmodus. <br>Gabapentin zeigte in diesem Modell eine Beeinflussung der zytoplasmatischen, Nipecotat-evozierten [3H]-GABA-Freisetzung, wenn dem Pharmakon nach ausreichender Einwirkzeit ein Einfluss auf den Metabolismus nach Inkubation mit dem Precursor …
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Development of a Kinetic Model to Investigate the Effect of Compositional Variation and a Processing Condition on the Solid-State Degradation of Gabapentin
<p>Gabapentin is used in the treatment of seizures and neuropathic pain. Gabapentin undergoes intra-molecular cyclization to form a γ-lactam. The product lactam is twenty times more toxic than gabapentin, causing seizures in animal models. The United States Pharmacopeia (USP) limits the content …
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Role of Mechanical Stress, Excipients and Coprocessing On Tablet Mechanical Properties
… sensitivity in the compactibility profile of gabapentin was further analyzed. Surface area analysis, indentation hardness measurements, and consolidation modeling were used to identify the role of compression speed on deformation behavior and internal porous structure of the gabapentin …
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A Pre-Clinical Assessment of Minocycline For Treatment of Chronic Neuropathic Pain After Spinal Cord Injury
… approved, current standard of treatment, gabapentin, only provides temporary pain relief. This treatment can cause numerous adverse side effects that negatively affect the daily lives of SCI patients. There is a great need for alternative, effective treatments for SCI-dependent CNP.</p> …
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Die Wirkung von Antikonvulsiva auf ATP-sensitive Kalium-Kanäle
Das Antikonvulsivum Gabapentin (Neurontin) zeigt bei der Behandlung von fokalen und se-kundär generalisierten tonisch-klonischen epileptischen Anfällen als Zusatztherapeutikum und seit jüngster Zeit auch als Monotherapeutikum eine gute Wirkung. Auch in der Schmerztherapie, wie etwa bei der …
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Neuroprotektion retinaler Ganglienzellen : Gabapentin-Laktam und die Neuropeptide NAP und Activity-dependent neurotrophic factor-9 in Kulturen isolierter Ganglienzellen und Netzhautexplantate der Ratte
GBP-L, das sich von Gabapentin ableitet, besitzt neuroprotektive Eigenschaften in vivo, vermutlich über das Öffnen mitochondrialer KATP-Kanäle. In der vorliegenden Arbeit untersuchte ich diese Hypothese an Kulturen isolierter retinaler Ganglienzellen (RGZ). <br>RGZ neugeborener Ratten (P0 - P2) …
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Cannabinoid Modulation Of Cisplatin Induced Neuropathy
… of mice were then given vehicle, 100 mg/kg gabapentin, 2 mg/kg thc or 2 mg/kg cbd ip and tested 60 m later on evf. In the prevention studies, cbd (0.0, 0.5,1.0, and 2.0 mg/kg) or thc (0.0, 0.5,1.0, and 2.0 mg/kg) was given ip 30 m prior to cisplatin administration (2.3 or 1.0 mg/kg) …
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Factors associated with co-prescription of opioids and gabapentinoids
<b>Background</b>: gabapentin and pregabalin are commonly used for relieving neuropathic pain, but also could lead to diversion, dependence and tolerance, with adverse effects on the central nervous system, especially when co-prescribed with opioids. The rates of prescribing gabapentinoids have …
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Die Modulation der Glutamatfreisetzung - ein Ansatz der neuroprotektiven Pharmakotherapie
… Transmission durch das Antikonvulsivum Gabapentin gezeigt werden. Gabapentin reduzierte die ischämisch-evozierte Freisetzung von [³H]-Glutamat um 35.7 <br>4. In ersten Versuchen konnte gezeigt werden, daß die Gabe von GBP-Lactam die Zahl überlebender Neurone nach retinaler Ischämie …
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Synthesis of sila-analogs and silicon-containing derivatives of drugs and development and application of the Si-2,4,6-trimethoxyphenyl moiety as a novel protecting group in organosilicon chemistry
… receptors, and a partial synthesis of sila-gabapentin. Crystal structure data of rac-sila-venlafaxine hydrochloride, (R)-sila-venlafaxine hydrobromide, bexarotene, disila-bexarotene, and disila-AG-045572 (disila-CMPD1) are included. Studies on the biological activities of sila-venlafaxine …
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The Effects of Cannabis Use on Cognitive Functioning in Adolescents and Young Adults
… for CUD by exploring the effects of the drug gabapentin vs. placebo for reducing cannabis related impairments in executive and daily functioning. Cognitive functioning was assessed with CANTAB and found no noticeable differences between gabapentin vs. placebo in cannabis related executive …
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The role of the periaqueductal gray in modulation of acute and chronic pain: Actions of drugs with analgesic properties on periaqueductal gray neuronal network
… responses as compared to pre-treatment levels. Gabapentin is an anticonvulsant that acts on N type voltage sensitive calcium channels and possesses analgesic properties in chronic pain syndromes. Gabapentin did not significantly affect PAG neuronal responses to acute pain in my initial studies …
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