Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"GPX4"”.
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Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death
… cold-resistant (BHK-21) cell line, and uncover GPX4 and related selenocysteine incorporation genes as important for protection against cold-induced cell death. Using genetic knockdowns, along with overexpression of GPX4, we confirm our findings and demonstrate that levels of GPX4 may be limiting …
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UPPER MOTOR NEURON BURDEN IN AMYOTROPHIC LATERAL SCLEROSIS: CLINICAL AND IMAGING FEATURES, AND THE ROLE OF IRON METABOLISM
… l’enzima Glutatione Perossidasi di tipo 4 (GPX4), che svolge un ruolo fondamentale nella regolazione della ferroptosi, è stato studiato attualmente solo nei modelli murini di SLA. L’obbiettivo di questo Progetto di Dottorato è studiare la correlazione tra il danno del primo neurone di moto …
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Antioxidant system remodeling underlies off-target effects of anti BCMA-Targeted Immunotherapy in Multiple Myeloma [Il rimodellamento del sistema antiossidante è alla base degli effetti off-target dell’immunoterapia anti-BCMA nel Mieloma Multiplo]
… potenziato, caratterizzato da alti livelli di GPX4, SLC7A11 e glutatione intracellulare. L’inibizione farmacologica di GPX4 ha ripristinato la perossidazione lipidica, sensibilizzando le cellule resistenti alla ferroptosi indotta da BeMa. Queste evidenze rivelano un legame critico tra …
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Dissecting the Roles of Cancer Cell Lipid Metabolism in Tumor Progression and Immune Evasion
… of cystine uptake or glutathione peroxidase-4 (GPX4), two pathways reported to mitigate lipid reactive oxygen species (ROS). Interestingly, very few genes were commonly required under both conditions, suggesting that cystine limitation and GPX4 inhibition may impair proliferation via distinct …
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ELUCIDATING THE ROLE OF HET0016 IN AMELIORATING 20-HETE INDUCED OXIDATIVE STRESS AND LIVER INJURY IN B-THALASSEMIA: A NOVEL THERAPEUTIC TARGET
… expression levels of glutathione peroxidase 4 (GPX4) in addition to measuring total glutathione (GSH) levels. Results: In Hbbth3/+ mice, there was an increase in intracellular ROS levels and NADPH oxidase enzymatic activity. At both mRNA level and protein level, in addition to IHC staining, a …
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Study of the Metabolic Effects of Water-alcoholic Extracts of Heartwoods with Traditional Use in Bulgaria // Проучване метаболитните ефекти на водно-алкохолни екстракти от дървесини с традиционно приложение в България
… to the endogenous antioxidant defense (GCL and GPx4) under conditions of oxidative stress and inflammation. Furthermore, scientific evidences were obtained about anti-inflammatory effect of the investigated extract demonstrated by decrease of gene expression of inflammatory cytokines and …
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Estudio de dos modelos de alcoholización en ratas adolescentes sobre el selenio y los sistemas de defensa antioxidante. Proyección a pacientes alcohólicos crónicos
… y la expresión de las selenoproteínas GPx1, GPx4 y selenoproteína P (SelP). Dado que la obtención de muestras de suero e hígado de pacientes alcohólicos expuestos a "binge drinking" era extremadamente compleja, nos propusimos estudiar el balance de Se, la actividad de las enzimas …
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Rhabdomyolysis-induced Acute Kidney Injury in Sickle Cell Disease
… peroxidation, as indicated by a reduction in GPX4 and an increase in 4-HNE. The use of antioxidants (TEMPOL, ferrostatin-1, and hydroxyurea) and iron chelators (deferiprone and, potentially, hydroxyurea) were able to ameliorate renal iron accumulation, oxidative stress, lipid peroxidation, and …
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Anorexia nervosa: investigation of markers of neuroinflammation, oxidative stress and synaptic plasticity using the activity-based anorexia rat model.
… involved in oxidative stress (CAT, MT1-α, GPX1, GPX4) in the prefrontal cortex (PFC) and dorsal hippocampus (dHPC) of female rats subjected to the activity-based anorexia (ABA) paradigm, a model which combines a restricted feeding schedule with unlimited access to a running wheel to successfully …
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Fatty acid regulation of adhesion molecule expression in human vascular cells.
… hydroperoxide glutathione peroxidease (GPx4). The aims of this project were to achieve a greater understanding of the mechanisms by which n-3 PUFA and CLA exert their influence on vascular cell functions and atherosclerosis. The above in vitro results give an indication as to the …