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Showing 1 to 20 of 93 for “"GM-CSF"”.

  1. Entwicklung von GM-CSF-produzierenden EBV-Vektoren für die Immuntherapie der B-CLL

    Hellebrand, EvaLudwig-Maximilians-Universität

    … zu entwickeln, die das therapeutische Zytokin GM-CSF in Tumorzellen von B-CLL-Patienten (Chronische lymphatische Leukämie) exprimieren. Dabei entscheidend ist die Eigenschaft von EBV naive, wie auch reife und maligne B-Lymphozyten über den CD21-Rezeptor spezifisch zu infizieren. Als Grundlage …

    lmu-germany Repository record

  2. Transcriptional regulation of the GM-CSF gene in T lymphocytes / Cameron Stuart Osborne.

    Osborne, Cameron Stuart1996

    Describes the investigation as to whether the mouse granulocyte-macrophage colony-stimulating factor and interleukin-3 genes are regulated in a similar manner as those of the human, focussing on regulation through an enhancer.

    adelaide Repository record

  3. Differentiation and activation of functionally distinct macrophage populations by CSF-1 and GM-CSF

    Rutherford, Mark StephenUniversity of Illinois at Urbana-Champaign2011

    … progenitor cells (BMDM) under the influence of CSF-1 or GM-CSF were compared for immune function. CSF-1- and GM-CSF-derived BMDM did not differ in their ability to kill L929 tumor targets or produce IL-6 and LTC$\sb4$ in response to IFN-$\gamma$ and LPS. CSF-1-derived BMDM secreted more …

    uiuc Repository record

  4. The Role of GM-CSF/IL-3/IL-5 Receptor Common β Subunit (CBS) in Hematopoietic Stem and Progenitor Cell (HSPC) Expansion, Monocytosis and Atherosclerosis

    Wang, Mi2013

    … colony-stimulating factor (GM-CSF) /Interleukine 3 (IL-3 receptor (CBS) in the bone marrow HSPCs and increased GM-CSF production in the spleen. These observations suggest that CBS signalling could contribute to atherogenesis by promoting myeloid expansion. To investigate the …

    columbia-diss Repository record

  5. Herstellung und funktionelle Analyse von Immunzytokinen, die Interleukin-2 (IL-2) oder Granulozyten/Makrophagen Kolonie-stimulierenden Faktor (GM-CSF) enthalten, zur Verbesserung einer NDV-modifizierten Tumorvakzine

    Aigner, MaximilianUniversität Heidelberg

    … und funktionellen Analyse neuartiger, IL-2- bzw. GM-CSF-enthaltender bi- und trispezifischer single-chain Antikörper (Immunzytokine) zur Verbesserung der antitumoralen Immunantworten bei Krebspatienten. Die Arbeit ist thematisch in ein Projekt zur Entwicklung einer aktiv-spezifischen Immuntherapie …

    heid-diss Repository record

  6. Controlling Pseudomonas aeruginosa Persister Cells by Human Granulocyte Macrophage Colony-Stimulating Factor

    Choudhary, Geetika Sanjay

    … macrophage colony-stimulating factor (GM-CSF), a cytokine produced by macrophages, T-cells, endothelial cells, and fibroblasts. We chose Pseudomonas aeruginosa as a model bacterium. It is an opportunistic pathogenic bacterium and a major cause of nosocomial infections in individuals …

    syracuse-diss Repository record

  7. NLRP2 expressziójának vizsgálata különböző immortalizált sejtvonalakon

    Bodrogi, Boglárka2022

    … során az volt, hogy megvizsgáljuk a GM-CSF és a dexametazon NLRP2 receptor expressziójára gyakorolt hatását különböző immortalizált humán sejtvonalakon. A kísérletek során THP-1, K562, Caco2, A549, NB4, U937, Hela és MCF-7 sejtvonalakat használtunk, melyeket 6, valamint 24 órás GM-CSF …

    debrecen Repository record

  8. The Anti-Inflammatory Effects of Low Concentrations of Carbon Monoxide in Human Airway Smooth Muscle Cells

    Ruiz, Jazmin 1980-The University of Texas Medical Branch at Galveston2016

    … macrophage colony stimulating factor (GM-CSF). However, the mechanism related to the decrease in GM-CSF release requires further exploration. Evidence demonstrates similarities in effect on oxidative stress and metabolism and subsequent effects on inflammation between hypoxic adaptation …

    utmb Repository record

  9. Tumor-induced macrophage and T cell dysfunction

    Walker, Thomas M.Virginia Tech1995

    … to MΦ colony-stimulating factor (M-CSF). M-CSF did not reverse decreases in autorecognition caused by TBH MΦ, and increased TBH MΦ suppression during T-cell alloreactivity. TBH suppressor activities were associated predominantly with MHC class II MΦ. TBH class II⁻ MΦ quantitatively …

    vt Repository record

  10. Untersuchung der Interleukin-5-Rezeptor-Expression und der Aktivierung humaner eosinophiler Granulozyten

    Gartenschläger, Sören

    … Zytokine IL-5 sowie IL-3 und GM-CSF nachzuweisen, im Sputum sind es erhöhte Konzentrationen des TH1-Zytokins IFN-g, sowie des für die Reparatur des zerstörten Bronchialepithels benötigten TGF-ß1. <br> Im Rahmen dieser Arbeit konnte das Überleben und die Expression des …

    freiburg-diss Repository record

  11. Role of dendritic cells in response to cytokine gene adjuvants

    Matthews, KatieThe University of Edinburgh2006

    … cytokine gene adjuvants to recruit DC, such as GMCSF and IL-3. The aim of the work carried out in this thesis was to investigate the effects of GM-CSF and IL-3 after gene-gun vaccination. Initial studies focused on the histological effects of GM-CSF and IL-3 in ovine skin. GM-CSF induced a …

    edinburgh Repository record

  12. Einführung rekombinant veränderter Newcastle Disease Viren als Vektoren für therapeutisch nutzbare Gene in der Tumortherapie

    Janke, MarkusUniversität Heidelberg

    … Wachstumsfaktor für T-Lymphozyten, und NDFL(GM-CSF) das Gen für humanen granulocyte-macrophage-colony stimulating factor (GM-CSF), der Einfluss auf antigen-präsentierende Zellen (APZ), wie z.B. Dendritische Zellen (DZ) hat. Es konnte gezeigt werden, dass Infektion mit NDFL(IL-2) oder …

    heid-diss Repository record

  13. Genexpression des Adaptorproteins Shc bei Patienten mit Juveniler Myelomonozytärer Leukämie (JMML)

    Feil, Bertram

    … ozyten-Makrophagen-Kolonie-stimulierenden Faktor (GM-CSF). Gehäufte Ras-Mutationen (30) und Ras-aktivierende Mutationen des Neurofibromin-Gens (30) weisen in JMML-Patienten auf eine Beteiligung dieses Transduktionswegs hin. Das Adaptorprotein Shc vermittelt zwischen dem stimulierten GM-CSF Rezeptor …

    freiburg-diss Repository record

  14. Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells

    Rolls, Barbara AnnThe University of Texas Medical Branch at Galveston2021

    … HASMC to sulfur dioxide does result in augmented release of GM-CSF, a pro-inflammatory cytokine that has been increasingly recognized as a major regulator of airway inflammation. However, we also found that sulfur dioxide reduced cigarette smoke-induced GM-CSF release from HASMC via …

    utmb Repository record

  15. Anti-Inflammatory Effect of Sulfur Dioxide and Sulfite on Cigarette Smoke Exposed Human Airway Smooth Muscle Cells

    Rolls, Barbara AnnThe University of Texas Medical Branch at Galveston2021

    … HASMC to sulfur dioxide does result in augmented release of GM-CSF, a pro-inflammatory cytokine that has been increasingly recognized as a major regulator of airway inflammation. However, we also found that sulfur dioxide reduced cigarette smoke-induced GM-CSF release from HASMC via …

    utmb Repository record

  16. Immunotherapy against malignant brain tumors - of mice and men

    Enell Smith, KarinDepartment of Clinical Sciences, Lund University2008

    … In paper I we demonstrate the establishment of a GM-CSF and IFNγ based immunotherapy in the mouse glioma model, GL261. Mice with intracranial gliomas were immunized intraperitoneally with GL261 cell genetically modified to produce GM-CSF combined with recombinant IFNγ. This combination …

    lund Repository record

  17. Der Einfluss von HLA-G und HLA-E auf Large Granular Lymphocytes

    Probe, ChristineUniversität Würzburg

    … der Sekretion der Zytokine TNF-a, IFN-g, GM-CSF, IL-5, IL-10, IL-13 und IL-15 gemessen. Dabei zeigte die Chorionkarzinomzelllinie JEG-3 eine Unterdrückung der TNF-a-, IFN-g-, GM-CSF- und IL-13-Produktion, aber eine Erhöhung der IL-10- und IL-15-Produktion gegenüber JAR. Möglicherweise …

    wurz-thes Repository record

  18. Combined chemotherapy and immunotherapy against experimental malignant brain tumors

    Fritzell, SaraLund University, Faculty of Medicine, Neurosurgery2013

    … macrophage-colony stimulating factor (GM-CSF). In the N32 rat glioma model there is a synergistic therapeutic effect when combining immunization with IFNγ- and- IL7-producing tumor cells and this coincides with enhanced systemic proliferation of CD4+ and CD8+ T cells, and an increase in …

    lund Repository record

  19. Immunoteratological Studies of Diabetic Embryopathy Using Gene Expression Analysis

    Punareewattana, KorawuthVirginia Tech2003

    … colony-stimulating factor (GM-CSF), or interferon-gamma (IFN-g), were used to stimulate the maternal immune system. Approximately 50% of fetuses from hyperglycemic (>27 mM/L) dams were malformed, with neural tube defects predominating. Maternal immune stimulation during the …

    vt Repository record

  20. Einfluß von Wachstumsfaktoren und Wachstumsfaktorkombinationen auf Angio- und Arteriogenese am ischämischen Kaninchenmyokard : eine histologische Studie

    Bredow, Anna Laura

    … Studie war, den Einfluss von VEGF-, FGF-2- sowie GM-CSF-Plasmid-DNA auf Angiogenese und Arteriogenese im ischämischen Kaninchenmyokard zu untersuchen. Desweiteren war von besonderem Interesse, ob und bei welcher DNA-Konzentration VEGF und FGF-2 synergistisch wirken könnten. Methoden: Eine Woche …

    freiburg-diss Repository record

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