Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 52 for “"GLUT4"”.
-
Over-expression of NRF-1 in C2C12 myotubes increases GLUT4 content via a transcriptional cascade involving MEF2A
… site on the mef2a gene, and MEF2A binds the glut4 gene as a MEF2A-MEF2D heterodimer, the aims of this study were to determine whether NRF-1 over-expression a) enhanced GLUT4 expression indirectly via MEF2A and b) alters MEF2A-MEF2D dimer formation in C2C12 myotubes.
-
Involvement of p300 in caffeine-induced hyper-acetylation of histones at the MEF2 binding domain on the Glut4 gene
Includes abstract. Includes bibliographical references.
-
Resistance Training Increases the Expression of AMPK, mTOR, and GLUT4 in Previously Sedentary Subjects and Subjects with the Metabolic Syndrome.
… Expression of glucose transporter protein-4 (GLUT4), the principle insulin-responsive glucose transporter, increased significantly in both groups. 5-adenosine monophosphateactivated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) expression increased in both groups, indicating …
-
Insulin Regulated Trafficking of Glucose Transporter 4: A Kinetic Perspective
… the amount of glucose transporter isoform 4 (Glut4) in the plasma membrane by recruiting the transporter from intracellular storage depots. Insulin regulation of Glut4 trafficking has been extensively studied, and although Glut4 partially overlaps with the general trafficking pathways, it is …
-
Regulation of Glut-4 Expression in Skeletal Muscle cells: The Roles of Nuclear Respiratory Factor-1 and calcium/calmodulin dependent protein Kinase
GLUT4 protein is the major glucose transporter in skeletal muscle and is vital in the maintenance of euglycemia (17; 108). Underexpression of GLUT4 or impairement of its translocation from intracellular compartments to the cell surface, are linked to diminished glucose transport, hyperglycemia and …
-
Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium
… of the insulin-regulatable glucose transporter (GLUT4) in skeletal muscle (84). Understanding the mechanisms by which exercise increases GLUT4 levels in skeletal muscle may reveal targets for pharmaceuticals to treat insulin resistance and type II diabetes. Although in vitro binding assays have …
-
Glucosensing, Hypoglycemia, and the Brain
… and centrally mediated. Within the periphery, GLUT4 in muscle and adipose tissue is required for normal glucose homeostasis and disruption of GLUT4 translocation in these tissues leads to glucose intolerance and insulin resistance, hallmarks of Type 2 diabetes. Within the brain, specialized …
-
Molecular analysis of insulin action using high throughput genetic screens
… of the insulin-regulatable glucose transporter GLUT4, which is rapidly translocated to the plasma membrane in response to the insulin signal. However, in the insulin resistant state, insulin is unable to effect a normal biological response in its target tissues, characterized by decreased …
-
The Mechanism of Palmitate Decreased Glucose Transpoter 4 Expression in C2 Myotubes
… 19 Ⅲ. 결과 21 A. 고농도 지방산의 지속적 노출에 의한 인슐린 저항성 및 GLUT4 양적 감소 21 1. ZDF 백서의 근육에서 GLUT4 mRNA 감소 21 2. 인슐린 저항성 및 GLUT4 양적 감소 21 3. GLUT4 promoter assay 22 4. mRNA 안정성 (Stability) 22 B. 고농도 지방산의 지속적 노출에 의한 GLUT4 양적 감소 기전 분석 27 1. 고농도 지방산에 의한 beta-oxidation 관련 약제의 영향 27 2. 고농도 지방산에 의한 synthesis 관련 약제의 …
-
Regulation of skeletal muscle glucose transporter 4 expression in fructose-fed exercised rats
… of skeletal muscle glucose transporter 4 (GLUT4) is decreased by high fructose consumption but increased by exercise. However, the amounts of fructose used in these studies were extremely high and the effects of moderate feeding protocols are not known. While it is known that exercise …
-
Effects of scriptaid on osteocytes skeletal homeostasis and metabolic functions
… genes related to energy utilization such as Glut4 and Pdk4. Thus we hypothesized that Scriptaid might regulate Sost and Glut4 expression in osteocytes. To investigate the effect of Scriptaid on osteocytes, we treated a mouse osteocytic cell line, Ocy454-12H, with Scriptaid. Unexpectedly, …
-
The effect of maternal nutrition on offspring gene regulation via epigenetic modulation
… of C/EBPβ at its promoter. On the other hand, GLUT4 is an insulin-regulated glucose transporter involved in insulin sensitivity and carbohydrate metabolism in muscle cells. We observed sex-dependent GLUT4 mRNA expression and increased GLUT4 protein content in female pup skeletal muscle with …
-
Role Of Hyperglycemia, Hypoglycemia, and Glucose Transporter 4 on Brain Glucose Sensing, Counterregulation, and Neuronal Viability
… 1) the role of neuronal glucose transporter 4: GLUT4) in glucose sensing and the counterregulatory response to hypoglycemia,: 2) the adaptive response of the brain to antecedent hypoglycemia, and: 3) the role of hyperglycemia and the hexosamine biosynthetic pathway: HBP) in the hypothalamus on …
-
Role of the Sh3 and Cysteine-Rich Domain 3 (STAC3) Gene in Proliferation and Differentiation of Bovine Satellite Cells
… membrane localization of glucose transporter 4 (GLUT4) and glucose uptake. These data together suggest the following mechanism by which STAC3 inhibits differentiation of bovine satellite cells: STAC3 increases AP1?1 stability in cells; a high level of AP1?1 keeps GLUT4 from translocating to the …
-
Exploring The Impact of Decreased Ampk Pathway Activity On Brain Injury Outcome
… glucose uptake via glucose transporter 4 (GLUT4). When AMPK is activated, it phosphorylates Akt Substrate of 160 kDa (AS160), a Rab GTPase activating protein that controls Glut4 translocation. Additionally, AMPK negatively regulates energy-consumption by inhibiting protein synthesis via the …
-
Understanding adipokine secretion and adipocyte-macrophage cellular interactions, in search for the molecular basis of insulin sensitivity and resistance
… significantly decreased insulin-stimulated GLUT4 translocation to the plasma membrane in a contact-independent manner. IL-6 was the most inhibitory cytokine in reducing GLUT4 translocation, GLUT4 expression, Akt phsphorylation and reducing adipocyte differentiation compared to TNF-alpha and …
-
The role of the mitofusins in adipose tissue
… expression of mature adipocyte markers (Plin1, Glut4, Adipoq), and insulin-stimulated glucose uptake. In contrast, though Mfn2-/- MEFs accumulated similar amounts of lipid to wild-type cells, they showed reduced PPARG and GLUT4 expression with minimal insulin-stimulated glucose uptake. RNA …
-
Regulation of Nutrient Metabolism in Equine Skeletal Muscle and Adipose Tissue
… of the insulin-sensitive glucose transporter (GLUT4). Lipopolysaccharide decreased insulin sensitivity regardless of pioglitazone pre-treatment, which was associated with decreased transcript abundance of GLUT4 in skeletal muscle and adipose tissue of untreated horses, but not adipose tissue of …
Page 1 of 3