Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Fusion transcripts"”.
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Novel methods in transcriptome analysis using RNA-seq
… Splice Junctions (SJs) and annotating gene fusion transcripts. Due to the limited read length of NGS data, it is extremely challenging to accurately map RNA-seq reads to SJs, which is important for the analysis of alternative splicing and isoform construction. In this thesis, we describe a …
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The structure and evolution of breast cancer genomes
… of these tumours as they can, for example, form fusion oncogenes or disrupt tumour suppressor genes. The recently described recurrent fusion genes in prostate and lung cancer proved to be iconic examples as they indicated that important gene fusions are found in the common epithelial cancers …
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Integrative Analysis of Omics Data In Adult Glioma and Other Tcga Cancers to Guide Precision Medicine
… <p>3) Comprehensive characterization of somatic fusion transcripts in Pan-Cancers. I have identified a panel of novel fusion transcripts across all of TCGA cancer types through transcriptomic profiling. Then I have predicted fusion proteins with kinase activity and hub function of pathway network …
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Genetic dissection of EGFRvIII brain and spinal mouse gliomas through whole-exome sequencing and in vivo piggyBac mutagenesis forward genetic screening
… Spred1. RNA-sequencing confirmed the presence of fusion transcripts (transposon mediated effects) for these genes. We demonstrate the clinical relevance of these cooperative genes through comparison with large human glioma databases, demonstrating recurrent genetic alterations of these genes are …
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Gene misexpression in humans
… deletions and 3 tandem duplications that created fusion transcripts, including a duplication associated with misexpression of myosin heavy chain 1 (MYH1), a gene normally expressed exclusively in skeletal muscle. Finally, I identified a partial gene inversion leading to transcript-specific …