Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"Formulation development"”.
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Preformulation and Formulation Development of a Novel Radioprotectant Drug
… NaOH (0.05 N) or hydrogen peroxide(1.5% v/v). Preformulation studies included determination of microscopic and macroscopic properties, partition coefficient, pKa, pH-dependant solubility, pH-dependant stability, solid-state characterization and solid-state stability. XRD (X ray diffraction) and …
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Evaluation of predictive computational modelling in biologic formulation development
… of computational modelling for protein drug formulation has numerous, currently unrealized, benefits. This project aims to be the first step in the development of a high throughput predictive computational model to screen for excipients that would decrease protein aggregation in solution and …
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Formulation development of a novel antivirulence compound for enhanced pharmacokinetic properties
… However, its clinical use is restricted by formulation challenges arising from its poor aqueous solubility. In this dissertation, plate-like or tube-like C790 nanoparticles with thickness down to one hundred nanometers have been successfully produced using antisolvent precipitation- …
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Formulation, development, and characterization of magnetic pastes and epoxies for thick film inductors
… work in this dissertation is aimed at the formulation of thick film ferrite pastes and ferrite epoxies and the design, construction, and evaluation of thick film spiral inductors. Wideband characterization (DC - 2GHz) of ferrite pastes, ferrite epoxies, and ferrite substrates is performed …
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Preformulation Characterization And Formulation Development of Δ9-Tetrahydrocannabinol Prodrugs For Potential Treatment Of Glacuoma
… to improve physicochemical properties. Preformulation characterization and formulation development for the THC prodrugs was undertaken. A high throughput in vitro model to screen the various formulations for transcorneal permeability was also developed. Promising formulations were instilled …
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Formulation Development of a Polymer-Drug Matrix with a Controlled Release Profile for the Treatment of Glaucoma
… the condition. This project reports the product development of a polymer drug matrix with a controlled release in order to better treat glaucoma. Accompanying product development, a mathematical model was created in order to strengthen the understanding of the dosage profile and to predict long …
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Pharmaceutical formulation development utilizing hot melt extrusion and other techniques for development of immediate and controlled release dosage forms
… of immediate as well as controlled release formulations for oral delivery of two model compounds. For immediate release applications lower molecular weight grades of Hydroxypropyl cellulose polymers, EF and ELF, were utilized as carrier matrices to form solid solutions of a poorly soluble …
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Development of Methods to Predict and Enhance the Physical Stability of Hot Melt Extruded Solid Dispersions
… solid dispersions is one of the most widely used formulation strategies for the enhancement of in-vitro and in-vivo performance of poorly water-soluble drugs. However, because of their meta-stable nature, the physical stability of amorphous solid dispersions has been considered to be the main …
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Design and development of drug delivery systems for immediate and sustained release utilizing hot melt extrusion
… have indispensable role in pharmaceutical formulation development. Polymer choice is a critical factor to obtain the desired drug-release profile during formulation development for HME (Hot melt extrusion). Many commercially available, pharmaceutical-grade polymers can be used in HME …
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An Assessment Of Forcite Approaches In Predictiing Young’s Modulus From Crystal Structure
… properties of pharmaceutical compound in pre-formulation stage facilitates tablet formulation development. A fast and accurate computational method for predicting crystal mechanical properties from crystal structure is extremely valuable since the availability of pharmaceutical active …
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A Quantitative Study of Drug Recrystallization in Drug-In-Adhesive Transdermal Patches Using Vibrational Spectroscopy
… methods are potential tools for supporting formulation development and physical stability evaluation of transdermal products in the pharmaceutical industry.</p>
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Thermal analysis of biochemical systems
… are injected. Historically, the majority of drug development, revenue, and products has come from small molecule drugs. However, recently biotherapeutic drugs have become more common due to their increased potency and specificity (the ability to chemically bond to the targeted protein of …
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Development of Binary Composite Solid Microparticles for Improved Intranasal Absorption of Low Permeation Drug Molecules
… objective of this work was to introduce a novel formulation strategy for intranasal delivery of two low permeation candidates: levodopa (L-DOPA; antiparkinsonism drug) and ribavirin (RBVN; an antiviral drug). The central hypothesis states that preparation of binary composite microparticles with …
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Exploring co-milling as a strategy to improve the dissolution of poorly water-soluble drugs
… The first major finding of this thesis was the development of a predictive model to quantify the dissolution enhancement achievable through co-milling. Using data from 29 crystalline drugs co-milled with PVP K25, key molecular and physicochemical properties, such as particle size, logD6.5, …
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The development of a predictive procedure for localised three dimensional river flows
This thesis contains the formulation, development and initial tests of a computer model for the prediction of fully three dimensional turbulent free surface flows typically found at localised areas of river systems. It is the intention that the model will be used to predict flow situations which …
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Extrusion foaming of bioplastics for lightweight structure in food packaging
… first to lay a solid foundation for formulation development. The influence of blending with other biopolymers, inclusion of filler, and chain extender additives in terms of mechanical properties, rheology, thermal decomposition and crystallization kinetics were then followed. Creating …
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Precisely size controlled drug-silica nanoconjugate for cancer therapy
… toxicology studies and addressing several formulation/development issues (e.g. salt-stability, scalability and lyophilizability, etc.), we developed a potentially clinically applicable, silica based drug-NCs with the optimized size for cancer therapy. My Ph.D. research not only established …
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The United Kingdom's Responses to Adverse Strasbourg Judgments: A Look Inside Government
… of judgments due to its de facto dominance of formulation, development and execution of public policy. Therefore, I look inside Government through interviews with current and former officials, ministers and advisers. I present my findings in four stages. First, I set out the people and …
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A Higher Order Accurate Finite Element Method for Viscous Compressible Flows
… identified, including improvement of the SU/PG formulation, development of more general grid generation strategies for higher order elements, the addition of a turbulence model to extend the method to high Reynolds number flows, and extension of the method to three-dimensional flows. An appendix …
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Physical analysis of solid solution formulations
… solid dispersion is the main challenge for their formulation development and commercialisation by pharmaceutical industry. The aims of the project were to prepare amorphous solid solution of a poorly aqueous soluble drug using different molecular weight mixtures of PEG and PEG mixed with other …
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