Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 216 for “"Flavonoid"”.
-
Flavonoid Consumption of College Athletes
<p>Flavonoids have great potential in prevention of several chronic diseases. The objective of this study was to determine the flavonoid intake levels, their major food sources, and effects of flavonoid intake on BMI from dietary data of 33 college athletes at South Dakota State University in 2011. …
-
Structural Characterization of the Flavonoid Enzyme Complex
Flavonoid biosynthesis is an important secondary metabolic pathway in higher plants with a range of vital functions in plants and animals. This pathway has been developed as a model system for the study of multi-enzyme complexes. The goal of the work presented here was to structurally characterize …
-
Immunomodulation of Flavonoid Biosynthesis in Transgenic Arabidopsis thaliana
… Arabidopsis chalcone isomerase (CHI) of the flavonoid biosynthetic pathway as the antigen. Each of the genes encoding the scFv's was cloned into a plant transformation vector, which was subsequently used to generate transgenic plants. One transgenic line with low expression of one of the …
-
Macronutrient-Flavonoid Interactions, Effects in Model Food Matrices
Macronutrient-flavonoid interactions have been well documented through the years. Chapter 1 of this document provides an introduction of the literature documenting the theoretical and mechanical framework of their importance in human health, biological interactions, macronutrient interaction, and …
-
Relationship Between Flavonoid Structure And Phase-II Metabolism
… relationships (SMRs) between UGTs and flavonoids for predicting glucuronidation of flavonoids. The goals of this research project were to: 1) identify the major UGT isoform(s) contributing to the glucuronidation of flavonoids and predicting the major organ of metabolism; 2) establish …
-
Beneficial Effect of the Flavonoid Luteolin on Neuroinflammation
… as well as the inverse relationship between flavonoid intake and cognitive decline in older persons and aged animals reported by others, we explored whether dietary supplementation of luteolin can ameliorate age-related deficits in spatial working memory and reduce inflammatory molecules in …
-
Enzyme structure, function, and evolution in flavonoid biosynthesis
… spread throughout terrestrial environments. Flavonoids are one particularly important class of plant specialized metabolites, playing a wide variety of roles in plant physiology including UV protection, pigmentation, and defense against herbivores and pathogens. Flavonoid diversity has …
-
Macromolecular organization of flavonoid biosynthesis in Arabidopsis thaliana
… the first step in a pathway that competes with flavonoid biosynthesis in other plant species. Moreover, it was shown that flavonols are not required for pollen viability in A. thaliana as they are in maize and petunia. I also describe a novel method to clone fragments of DNA without ligase using …
-
Flavonoid protection of cardiac cells against ischemia-reperfusion injury
… Polyphenols, and in a more specific category, flavonoids are strong antioxidants, while possessing other biological activities such as anti-apoptotic, anti-inflammatory, and vasodilatory effects. I hypothesized that flavonoids are able to reduce ischemia-reperfusion-induced cell death through …
-
Flavonoid Intake and Periodontal Healing Outcomes Following Sanative Therapy
… with periodontal disease. Due to the high flavonoid content in tea and the anti-inflammatory and anti-oxidant properties of flavonoids, it was hypothesized that participants with higher daily intakes of tea and flavonoids would have improved healing outcomes, designated as greater …
-
Tokaji borok polifenol- és flavonoid tartalmának, valamint antioxidáns kapacitásának vizsgálata
… az összes polifenol tartalom, az összes flavonoid tartalom, illetve a nem flavonoid fenolok mennyisége, valamint a FRAP módszerrel meghatározott antioxidáns kapacitás képezték. Arra próbáltam választ adni, hogy a tokaji borkülönlegességek mennyire tekinthetőek kiemelkedőnek …
-
The significance of OATP and CYP450 in statin-flavonoid interactions
… evidence that a class of phytochemicals known as flavonoids may be able to inhibit hepatic absorbance and metabolism, comparable to drugs that are known to have drug-drug interactions with statins. Chapter 1: “Flavonoid-statin interactions causing myopathy and the possible significance of OATP …
-
Molecular Genetics and Subcellular Localization of Flavonoid Metabolism in Arabidopsis
… here was to test the metabolon model using the flavonoid biosynthetic pathway in Arabidopsis, which has been hypothesized to exist as a metabolic enzyme complex. Five novel mutants of the gene encoding the first enzyme of flavonoid biosynthesis, chalcone synthase (CHS), were characterized in an …
-
Exploring protein interactions and intracellular localization in regulating flavonoid metabolism
… and regulated are still not well understood. The flavonoid biosynthetic pathway offers a unique system in which to study several important aspects of metabolism. Here we describe a novel toolset of mutant alleles within the flavonoid biosynthetic pathway. In addition, we discuss the use of several …
-
Proteomic Analysis of the Flavonoid Biosynthetic Machinery in Arabidopsis Thaliana
… for the regulation of cellular metabolism. The flavonoid biosynthetic pathway of Arabidopsis is an excellent model for studying the organization, localization, and regulation of enzyme complexes at the cellular level. Flavonoids are specialized metabolites that perform many important …
-
Development of antibodies for characterizing the Arabidopsis flavonoid biosynthetic pathway
… first two enzymes of the Arabidopsis thaliana flavonoid biosynthetic pathway were developed using conventional and phage antibody technology. cDNAs from Arabidopsis coding regions of chalcone synthase (CHS) and chalcone isomerase (CHI) were sub-cloned in frame into a bacterial expression vector …
-
Predicting Flavonoid UGT Regioselectivity with Graphical Residue Models and Machine Learning.
… classification problem: the prediction of flavonoid UGT acceptor regioselectivity from primary protein sequence. Novel indices characterizing graphical models of protein residues are introduced. The indices are compared with existing amino acid indices and found to cluster residues …
-
Flavonoid diversification in Hibiscus and its impact on petal pattern evolution
… model system, bullseye patterns are formed by flavonoid pigments including anthocyanins and flavonols. Their flowers display a contrast between a purple base and an off-white distal region. H. trionum belongs to the Trionum Complex native to Australia and New Zealand, whose members vary in …
-
Flavonoid Intake and Prostate Cancer Aggressiveness In African Americans and European Americans
… have reported an inverse association between flavonoids and prostate cancer cell growth. This association is thought to be due to the anti-inflammatory properties of flavonoids, as well as their ability to induce apoptosis, impair angiogenesis, and inhibit cancer cell proliferation. The …
Page 1 of 11