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Showing 1 to 20 of 37 for “"FasL"”.

  1. Role of Fas/FasL, inflammatory mediators and LPS-activated macrophages in human neutrophil apoptosis

    Murray, Lorna AnnThe University of Edinburgh2007

    … no evidence of expression of its natural ligand (FasL). An agonistic anti-Fas monoclonal antibody (CH-11) accelerated neutrophil apoptosis under certain culture conditions. Lipopolysaccharide (LPS) originating from Gram-negative bacteria is often found at sites of inflammation. We have shown that …

    edinburgh Repository record

  2. The Histone Deacetylase Inhibitor, Ms-275, Sensitizes Metastatic Osteosarcoma to Fasl-Induced Cell Death: A Role For C-Flip

    Bindal, Krithi R2012

    … of osteosarcoma (OS) to Fas ligand (FasL)-induced cell death. OS metastasizes almost exclusively to the lungs. We have shown that Fas expression in OS cells is inversely correlated with their metastatic potential. Fas<sup>+</sup> cells are rapidly eliminated when they enter the lungs …

    uthsc Repository record

  3. Untersuchung der Rolle des Fas/FasL-Systems bei der Auslösung der Apoptose durch Tumorzellen in Fas-knock out-Makrophagen

    Griesbaum, Sven

    … dieser Werte und der Überlegung, ob dem Fas/FasL-System eine bedeutende Rolle in dem o.g. Apoptosegeschehen zugemessen werden kann, sollten in dieser Arbeit Fas-k.o.-Mäuse mit den gleichen drei Apoptosemarkern unter den gleichen Bedingungen angefärbt werden. <br>Um die Untersuchungszeitpunkte …

    freiburg-diss Repository record

  4. Fas ligand expression and tumour immune evasion; the role of prostaglandin E2 and the EP1 receptor

    O'Callaghan, GraceUniversity College Cork2013

    … immune response. Upregulation of Fas Ligand (FasL/CD95L) expression may represent one such mechanism. FasL is a member of the tumour necrosis factor superfamily that triggers apoptotic cell death following ligation to its receptor Fas. Numerous studies have demonstrated upregulated FasL …

    cork Repository record

  5. Experimentelle Untersuchungen zur Interaktion von Fas mit seinem Liganden an normalen und neoplastischen Zellen des lympho-hämatopoetischen Systems

    Richter, Manfred

    Fas-Ligand (FasL) stellt einen der 2 Effektormechanismen dar, mit dem T-Zellen den programmierten Zelltod induzieren. Die FasL-Expression auf Tumorzellen wurde in letzter Zeit als ein möglicher Mechanismus angesehen, mit dem sich Tumorzellen der Immunantwort des Körpers entziehen. Die Datenlage …

    freiburg-diss Repository record

  6. Tumor cell-immune cell interaction: A lethal two way street

    Zeytun, AhmetVirginia Tech1999

    … apoptosis in Fas+, LSA tumor cells using the FasL-based pathway. However, LSA and EL-4 tumor cells constitutively expressed Fas ligand and killed Fas+ PE-9 CTLs and Fas+, but not Fas-negative (Fas-) activated T cells and thymocytes. These data suggested that T cells and cancer cells can kill …

    vt Repository record

  7. Role of CD44, Fas Ligand, and Perforin in the Cytotoxicity Mediated by Natural Killer Cells

    Bradley, Michael JosephVirginia Tech1997

    … one perforin based and the other Fas ligand (FasL) based, have been characterized recently. It has also been shown that CD44, an adhesion molecule, can participate in signaling cytotoxic activity of cytotoxic T lymphocytes (CTLs). In the current study we tested the hypothesis that activation …

    vt Repository record

  8. Characterisation of the role of Fas in intestinal inflammation and cancer

    Fernandes, PhilanaUniversity College Cork2015

    … role of Fas (CD95) and its ligand, Fas ligand (FasL/CD95L), is poorly understood in the intestine. Whilst Fas is best studies in terms of its function in apoptosis, recent studies suggest that Fas ligation may mediate additional, non-apoptotic functions such as inflammation. Toll like Receptors …

    cork Repository record

  9. Nachweis des apoptoseinduzierenden Faktors in Lewis-Lung-Karzinom Zellüberstand nach Inkubation von Kulturmakrophagen der C57/BL6 Maus

    Woisetschläger, Mischa

    … und anschließend auf das Vorhandensein von FasL mRNA mittels RT-PCR untersucht. Zur Verdeutlichung des Apoptoseverhaltens der Kulturmakrophagen, wurde bei diesen vom 10.-12. Kulturtag nach Zugabe von Zellkulturüberstand aus 3-LL Tumorzellen zu 3 verschiedenen Inkubationszeiten mittles …

    freiburg-diss Repository record

  10. Cell-surface Tumoricidal Molecules and NF-kB in the Tumor-burdened Host

    McConnell, Michael JamesVirginia Tech2002

    … I analyzed the expression of Fas and FasL on freshly isolated and LPS-stimulated macrophages and found no differences between TBH and NH macrophages. Fas and Fas ligand (FasL) cell-surface expression was analyzed on NH and TBH T-cells. While no difference was observed in freshly …

    vt Repository record

  11. Molecular mechanisms mediating the induction of apoptosis by chemopreventive selenium compounds

    Ghose, AurnabUniversity of Glasgow2001

    … with a strong induction of Fas ligand (Fasl). Blocking Fas activation resulted in inhibition of apoptosis. Activities of stress kinases INK (c-jun N-terminal kinase) and p38 were also induced on selenium treatment and intervention studies using specific chemical inhibitors and/or …

    glasgow Repository record

  12. Vitrification of Bovine Oocytes

    Anchamparuthy, Vahida Muhammed IsmailVirginia Tech2007

    … assess changes in apoptotic gene expression (Fas-FasL, Bax, Bcl-2, and survivin) in conjunction with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase assays. Mouse zygotes were exposed to increasing concentrations of ethylene glycol (EG), Ficoll-70 and sucrose in …

    vt Repository record

  13. Placental angiogenesis and immune-privilege in normal and pathological pregnancies

    GANGARAJU RAJA SHEKHAR2004

    … which indicated co-expression of Fas and FasL in malignant trophoblasts. The data suggest that choriocarcinoma cells could evade immune attack by down regulation of Fas receptors and by killing lymphocytes through expression of FasL.

    nus Repository record

  14. Molekulare Mechanismen des Tumorzelltodes induziert durch die Suizidgene Thymidinkinase und Purinnukleosidphosphorylase

    Krohne, Tim U.

    … p53-positiven HepG2-Zellen und von Fas-Ligand (FasL) in beiden HCC-Zellinien. Diese Resultate demonstrieren zellinienspezifische Unterschiede in der Reaktion auf die Behandlung mit PNP/Fludarabin beziehungsweise TK/GCV und deuten darauf hin, dass PNP/Fludarabin gegenüber TK/GCV aufgrund seiner …

    freiburg-diss Repository record

  15. Frühe Entwicklungsschritte in der Pathogenese der B-Zell-Lymphome vom mukosa-assoziierten lymphatischen Gewebe (MALT)-Typ

    Seeberger, Harald Bruno GustavUniversität Würzburg

    … des apoptose-induzierenden Oberflächenmoleküls FasL auf aktivierten T-Zellen mit dem entsprechenden Todesrezeptor Fas auf malignen B-Zellen zu untersuchen. Drei von sieben MALT-Typ Lymphomen und vier von fünf DLBL erwiesen sich als resistent gegen FasL-vermittelte Apoptose. Meine Untersuchungen …

    wurz-thes Repository record

  16. The mechanism of T cell dysfunction induced by Diethylstilbestrol

    Brown, Nicole Chantae2014

    … T cell apoptosis in the thymus. Additionally, FasL expression was increased onthymic stromal cells following DES exposure. Furthermore, the presence of both FasL onstromal cells and Fas on T cells was important for inducing T cell apoptosis in thethymus.

    vcu Repository record

  17. Die Bedeutung zytotoxischer Effektormoleküle bei der ConA induzierten Hepatitis

    Grosse, Philipp

    … von ZTL, insbesondere Perforin, GzmA, GzmB, FasL und Fas, wurde in dieser Arbeit die molekulare Basis der pathologischen Vorgänge näher charakterisiert.

    freiburg-diss Repository record

  18. Role of CD44 in Immune Functions and Endothelial Cell Injury

    Rafi-Janajreh, AsimahVirginia Tech1998

    … in VLS in all three organs tested. Also, FasL-defective (gld) mice and Fas-deficient (lpr) mice exhibited decreased VLS in the liver and spleen, but not in the lungs. These results demonstrated for the first time that perforin and FasL may actively participate in endothelial cell injury …

    vt Repository record

  19. Untersuchungen zur Rolle von zytotoxischen Molekülen bei der Immunabwehr gegen Retroviren

    Zelinskyy, GennadiyUniversität Würzburg

    … dass F-MuLV von CD8+ T-Zellen über den Fas/FasL Weg kontrolliert wurde. Das pathogene Potential von Retroviren scheint also einen Einfluß auf den jeweils verwendeten Abwehrmechanismus von zytotoxischen T-Zellen zu haben. Trotz der wichtigen Funktion von CD8+ T-Zellen bei der Kontrolle der …

    wurz-thes Repository record

  20. Targeted therapies in mantle cell lymphoma

    Tucker, Catherine AmandaUniversity of British Columbia2008

    … how abnormal expression of CD40/CD40L and Fas/FasL along with bcl-2 family members contributes to B cell clonal expansion and influences Rituximab-mediated cell death in MCL models. Rituximab is a chimeric monoclonal antibody targeted against B cells and both Rituximab-sensitive and insensitive …

    ubc Repository record

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