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Showing 1 to 9 of 9 for “"FSGS"”.
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Electron microscopic morphometry of podocyte foot process effacement as a tool to distinguish primary from secondary focal segmental glomerulosclerosis (FSGS)
Background: Focal segmental glomerulosclerosis (FSGS) is a histological pattern of glomerular injury and one of the most common causes of end-stage renal disease in adult patients. Two major subtypes of FSGS (primary oand secondary) have been identified, with differences in clinical presentation, …
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alpha-Actinin-4 and the podocyte: Implications for focal segmental glomerulosclerosis
Focal and segmental glomerulosclerosis (FSGS) is a common glomerular lesion and a significant cause of end-stage renal disease (ESRD). FSGS lesions result from damage to glomerular epithelial cells called podocytes, a key cell type involved in glomerular filtration. Mutations in the ACTN4 gene, …
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Clinical Presentation and Histopathological Description of the Spectrum of Renal Diseases in HIV Infected Adults Presenting With Renal Insufficiency at the University Teaching Hospital,Lusaka Zambia
… (32%) and focal segmental glomerulosclerosis (FSGS) (29%) of various histologic variants other than the collapsing type. We did not see the classic HIVAN on histopathology in our study population. All the patients presented with severe renal dysfunction with mean eGFR of 17 ml/min/173m2 and …
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Clinical Presentation and Histopathological Description of the Spectrum of Renal Diseases in HIV Infected Adults Presenting With Renal Insufficiency at the University Teaching Hospital,Lusaka Zambia
… (32%) and focal segmental glomerulosclerosis (FSGS) (29%) of various histologic variants other than the collapsing type. We did not see the classic HIVAN on histopathology in our study population. All the patients presented with severe renal dysfunction with mean eGFR of 17 ml/min/173m2 and …
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Mutationsanalyse der Gene NPHS2 und WT1 bei Patienten mit steroidresistentem Nephrotischen Syndrom im Kindesalter
… in die TNI und den histologischen Befund FSGS oder MCNS. Ursache dieser Erkrankung sind Mutationen im NPHS2-Gen auf Chromosom 1q25-q31, das Podocin kodiert. Ein weiteres Gen, das ein Nephrotisches Syndrom im Kindesalter verursacht, ist WT1 auf Chromosom 11p13. Heterozygote …
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Exom-Sequenzierung bei unklarer chronischer Niereninsuffizienz anhand definierter renaler Biopsiemerkmale
… wir Gene für glomeruläre Nephropathien (FSGS und COL4-Nephropathie/Alport-Syndrom) und kongenitale Nierenanomalien (CAKUT). Die dabei detektierten genetischen Varianten wurden auf mögliche Pathogenität anhand der ACMG-Klassifizierung final bewertet. Daraus resultierten bei vier Probanden …
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Mutationsanalyse der verantwortlichen Gene NPHS2 und Wilms-Tumor-Suppressorgen beim Nephrotischen Syndrom
… meist eine Fokal-segmentale Glomerulosklerose (FSGS) (ca. 75%) oder ein Minimal-change NS (MCNS) (ca. 25%). Eine Ursache dieser Erkrankung sind Mutationen im NPHS2-Gen auf Chromosom 1q25-q31, welches für das Protein Podocin kodiert. Das Wilms-Tumor-Suppressorgen WT1 konnte als ein weiteres Gen …
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Efficient modeling and waveform inversion of multicomponent seismic data for anisotropic media
… (MFD) operators and fully staggered grids (FSGs). Also, I present an EFWI framework based on these propagators and discuss inversion strategies for estimating the parameters of coupled fluid/solid VTI (transversely isotropic with a vertical symmetry axis) media using multicomponent …
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Ca²⁺ and phosphoinositides regulations in α-actinin -4 F-actin binding.
… (SCLC) and focal segmental glomerulosclerosis (FSGS). The mutation site within these mutants is located on the actin binding region. Therefore, the actin binding region is presumed to be associated with the progression of human disease. The aims of this thesis focused on the regulation of the …