Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Extraocular"”.
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The Effects of Extraocular Muscles on Eye Biomechanics
… investigated for years; however, the role of the extraocular muscles in relation to eye injuries has yet to be quantified. In this research, Computed Tomography quasi-static tests were conducted to investigate the effect of the presence of the extraocular muscles on the biomechanical response of …
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Growth factors in extraocular muscles: effects on contractile properties
Extraocular muscles are a unique group of skeletal muscles, with distinct biological properties, including specialized myofiber types, a unique transverse and longitudinal organization of myofibers, continued muscle plasticity and the retention of activated progenitor cells in adult normal muscles. …
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Neuromuscular junction formation in Extraocular muscles of embryonic mice
… to and properly innervate the appropriate extraocular muscles. If proper innervation does not take place, congenital cranial dysinnervation disorders result. One of these disorders is strabismus, a misalignment of the eyes. Despite the importance of the oculomotor system, little is known …
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The Effects of Self-Regulated Extraocular Muscle Tension on Intraocular Pressure.
… study was to examine the relationship between extraocular muscle tension and fluctuations in intraocular pressure (IOP) in normal subjects. Twenty subjects were asked to increase and decrease their EMG activity from the orbicularis muscle around the eye according to a biofeedback paradigm. …
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Duchenne muscular dystrophy and extraocular muscle: a potential sparing mechanism with therapeutic implications.
This project investigates the role of extraocular muscle (EOM) progenitor cells in sparing the muscles from pathology associated with Duchenne Muscular Dystrophy (DMD). Mouse models of muscular dystrophy and wild type mice were analyzed by flow cytometry and cell culture for the size, heterogeneity …
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Molecular analysis of decay accelerating factor as a potential susceptibility factor to developing treatment resistant extraocular muscle involvement in Myasthenia Gravis
… develop immunosuppressive therapyresistant extraocular muscle (EOM) dysfunction. We hypothesized that these patients have deficient DAF expression in their EOMs resulting in less protection from complement injury.
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Development of the ocular motor system in mouse embryos
… obtain precise visual feedback. In humans, six extraocular muscles form an oppositional pulley system to mediate slow, smooth tracking events as well as fast saccades. Their movement is dependent on three cranial nerves: the oculomotor, trochlear, and abducens. This study focuses on the …
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Treatment-resistant ophthalmoplegia in Myasthenia gravis: extraocular muscle pathology, the role of TGFβ1 and the derivation of induced pluripotency towards 'disease-in-a-dish' modeling
… muscle weakness. MG frequently affects the extraocular muscles (EOMs) early in the course of the disease, resulting in diplopia and ptosis, which is usually reversible with treatment. A treatment-resistant ophthalmoplegia and ptosis occurs as a complication of MG in a distinct subset of …
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A Nonlinear Finite Element Model of the Human Eye to Investigate Ocular Injuries From Night Vision Goggles
… models of the eye, such as the fatty tissue, extraocular muscles, and bony orbit were included in this model. In addition, this model includes material properties up to rupture making the eye suitable for large deformation applications. The model was imported into Madymo and used to determine …
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Laminins in blood vessel development and disease -functional aspects in angiogenesis, atherosclerosis, and muscular dystrophy
… as a potential receptor for laminin ?4LG4-5. The extraocular muscles are selectively spared from muscle wasting in some muscular dystrophies, including a mouse model of muscular dystrophy arising from complete absence of laminin ?2 chain. This model was used to identify the cause of this …
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Force-extension of the Amylose Polysaccharide
… develop immunosuppressive therapy-resistant extraocular muscle (EOM) dysfunction. We hypothesized that these patients have deficient DAF expression in their EOMs resulting in less protection from complement injury. Sequence analysis of relevant regions of the DAF gene revealed a single …
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Treatment-resistant ophthalmoplegia in myasthenia gravis: Clinical, molecular and functional studies of patient-derived orbital tissues
… the neuromuscular junction. Weakness of the extraocular muscles (EOMs) occurs frequently in MG and typically responds to immune therapies similarly to the non-ocular muscles. Susceptible individuals with the ophthalmoplegic subphenotype of MG (OP-MG), which occurs almost exclusively in …
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Identification and characterisation of novel marker proteins involved in X-linked muscular dystrophy
… cardiac muscle and the naturally protected extraocular muscle were used to explore pathogenesis of the disease. A mass spectrometry-based approach combined with the highly sensitive difference in-gel electrophoresis technique was used to reveal changes and identify novel biomarkers in the …
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Sources and Targets of Trophic Factors in the Avian Locus Coeruleus and Oculomotor System
… of insulin-like growth factor I (IGF-I) for extraocular muscles (EOM). IGF-I is a potent myogenic growth factor. The oculomotor system studied in this project contains three components: the superior oblique muscle (an EOM), the trochlear nucleus (cranial nucleus that contains the motoneurons …
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Investigating the functionality of candidate susceptibility genes in ophthalmoplegic myasthenia gravis using patient-derived material
… described by our group is characterised by extraocular muscle (EOM) weakness which does not respond to standard immunosuppressive therapy whilst the non-ocular muscles do respond to treatment. OP-MG predominantly affects patients of African genetic ancestry and most commonly those with …
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The Use of Preclinical Models to Improve the Treatment of Retinoblastoma
… posterior chamber in more detail along with the extraocular space. With different software programs, the tumor to eye ratio volume measurement were determined and compared to the gold standard of enucleation, embedding, serial sectioning and hand tracing. It was found that there was a better …
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Molecular bases, pathogenic mechanisms and possible therapeutic approach in Leber's Hereditary Optic Neuropathy
… LHON mutations, thereby giving rise to the extraocular clinical features characteristic of the LHON â��plusâ�� phenotype. We identified the first molecular parameter that clearly discriminates LHON affected individuals from asymptomatic carriers, the mtDNA copy number. This provides a …
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Measured and calculated dose distributions in the “claws” – a specially designed gold applicator loaded with I-125 seeds
… a pericorneal ring is attached to the four extraocular muscles, and four legs, each loaded with I125 seeds, are inserted beneath the conjunctiva in-between each pair of muscles and attached anteriorly to the ring. The four legs that are now sutured onto the ring give it a claw-like …
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Identifying the molecular basis for treatment resistance in a subset of myasthenia gravis patients of African ancestory
… of African genetic ancestry develop a severe extraocular muscle (EOM) phenotype whilst receiving standard immunosuppressive drug therapies. This phenotype associates with a functional c.-198C>G SNP (C>G SNP) in the regulatory region of decay accelerating factor (DAF), a complement regulatory …