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Showing 1 to 20 of 53 for “"Erythropoietin"”.
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Symmetric signaling by an asymmetric 1 erythropoietin : 2 erythropoietin receptor complex
One erythropoietin molecule binds asymmetrically to two identical receptor monomers via erythropoietin site 1 and site 2, although it is unclear how asymmetry affects receptor activation and signaling. Here we report the computational design and experimental validation of two mutant erythropoietin …
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The biogenesis of erythropoietin during inflammation
… A contributing factor could be the inhibition of erythropoietin synthesis which may also be mediated by cytokines. Erythropoietin is the hormone which regulates erythropoiesis. The aims of this project were to investigate whether cytokines can indeed suppress erythropoietin production, and to …
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The impact of erythropoietin on uraemic cardiomyopathy
… LVH), which contribute to heart failure. Erythropoietin (EPO) has evolutionised the treatment of the anaemia associated with CKD. The discovery that the EPO receptor is also expressed on cardiomyocytes highlights a role of EPO beyond haematopoiesis. However, little is known on the cellular …
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Tuberculosis, Anaemia and Erythropoietin: a study evaluating the role of erythropoietin in the pathophysiology of the anaemia of tuberculosis
… elucidated. With the advent of recombinant human erythropoietin (Epo ), it has become evident that a blunted Epo response to the anaemia plays a major role. The mechanism (s) involved still have to be elucidated. The aims of, this study were to evaluate serum Epo levels and iron parameters in …
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Signal Transduction Effects Induced by Erythropoietin in a HNSCC Model System
… the body lacks mature red blood cells (RBCs). Erythropoietin (EPO) is a systemically circulating hormone in the body that regulates the production of RBCs and is applied to treat anemia. Recently, several studies implicated shortened life expectancy of cancer patients by EPO administration. It …
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Verbesserung kognitiver Leistungen bei chronischer Schizophrenie durch rekombinantes humanes Erythropoietin (rhEPO)
… Hypothese lautet, dass rekombinantes humanes Erythropoietin (rhEPO) als neuroprotektive/neurotrophe Add-On Strategie zusätzlich zu einer stabilen antipsychotischen Medikation kognitive Funktionen verbessern kann. Aus diesem Grund wurde eine doppelblinde, Placebo-kontrollierte, randomisierte …
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Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer
The main function of erythropoietin (EPO) is in hematopoiesis where EPO stimulates increased proliferation, survival and differentiation of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different …
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Expression and function of erythropoietin and its receptor in invertebrate nervous systems
… erste Hinweise für das Vorhandensein eines Erythropoietin/Erythropoietinrezeptor (EPO/EPOR) Signalsystems im Nervensystem von Invertebraten (Kapitel 2) und weist einen neuroprotektiven und neuroregenerativen Effekt von humanen EPO auf neuronale Zellen von Insekten in vivo (Kapitel 3) und in …
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The role of erythropoietin in the pathophysiology of anemia associated with trypanosomiasis
… and livestock in sub-Saharan Africa. A blunted erythropoietin (Epo) response has been proposed as one possible mechanism that contributes to the nonresponsive anemia in trypanosome-infected cattle. The overall objective of this study was to examine the pathophysiologic role of Epo in the anemia …
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Erythropoietin for the Treatment of Porphyria Cutanea Tarda in End Stage Renal Disease
… results largely from decreased production of erythropoietin by the diseased kidneys. Erythropoietin administration can mobilize excess iron, correct anemia and support phlebotomy in these patients. This study will analyze data from an unblinded trial of 6 patients who were treated with …
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Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema
… smoother transitions from bench to the bedside. Erythropoietin (EPO), a hematopoietic growth factor that increases oxygen availability during hypoxia/ischemia is associated with cell survival and neuroprotection in: in vivo and in vitro models of hypoxia ischemia. However these studies hold …
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Erythropoietin Signaling in Pancreatic Beta Cells in Homeostasis and in Models of Type 1 and Type 2 Diabetes
… and treatment. Evidence has suggested that erythropoietin (EPO) exerts cytoprotective effects on non-erythroid cells. However, the in vivo role of EPO on the pancreatic β cells has not been evaluated to date. We hypothesized that EPO would have direct cytoprotective effects on the pancreatic …
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Mechanisms of Erythroid Proliferation and Differentiation: Analysis of the Role of Erythropoietin Receptor in the Friend Virus Model
… Extracellular signaling molecule, particularly erythropoietin (EPO), plays a critical role in this process by activating its receptor (EPOR) which is highly expressed in late erythroid progenitor cells. Although the molecular mechanisms of how EPOR signaling functions have not been entirely …
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Tackling the bigger picture in computational drug design : theory, methods, and application to HIV-1 protease and erythropoietin systems
This thesis addresses challenging aspects of drug design that require explicit consideration of more than a single drug-target interaction in an unchanging environment. In the first half, the common challenge of designing a molecule that recognizes a desired subset of target molecules amidst a …
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Erythropoietin treatment in anaemic patients at the Nephrology Unit of the Steve Biko Academic Hospital - a retrospective, cross-sectional study
… results from a decrease in the production of erythropoietin (EPO) by the failing kidney. CKD progression requires treatment with erythropoiesis-stimulating agents and iron supplementation to ensure sufficient erythrocyte production. Best clinical practice guidelines should be adhered to in …
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Expression eines rekombinanten humanen Proteins in vitro und in vivo in Eileiterzellen des Huhnes, am Beispiel von humanem Erythropoietin, hrEPO
… eine zellspezifische Expression von ErythropoietinErythropoietin wird aktuell auf seine biologische Aktivität untersucht, die Veröffentlichung der Ergebnisse befindet sich in Vorbereitung. erreicht werden, die Transfektion hat sich als stabil erwiesen. Das so gewonnene
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Indirekte und direkte Methoden zur Detektion des Erythropoietindopings
Das Problem des Missbrauchs von Erythropoietin (EPO) als Dopingsubstanz zur Steigerung der Ausdauerleistung wurde schlagartig weltweit durch den Skandal zur Tour de France 1998 bekannt. Das Internationale Olympische Komitee (IOC) führte ab 1992 Erythropoietin explizit auf der Liste der verbotenen …
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Experimentelles Neurotrauma im Mausmodell
… eines Therapieversuchs mit systemischer Erythropoietinapplikation.Es wurde bei insgesamt über 90 juvenilen Mäusen (C57BL/6J männlich, Alter 4 Wochen) eine standardisierte Kälteläsion mittels Stereotaxie im rechtsparietalen Kortex appliziert (1.5 mm posterolateral des Bregmas, Durchmesser …
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