Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 139 for “"Epithelial-to-Mesenchymal-Transition"”.
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Characterization of Human Airway Epithelial to Mesenchymal Transition upon Rhinovirus Infection
… illnesses in early life are a major risk factor for subsequent asthma development, and may contribute to induction and progression of airway remodeling (AR) seen in the airways of asthmatic subjects. Thickening of the lamina reticularis is a component of AR that is due to increased deposition …
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The Epithelial to Mesenchymal Transition In Breast Cancer Induces Alterations In Metabolism
… will shed light on developing novel ways to treat metastasis and is of urgent clinical need. A potent mediator of metastatic potential in breast cancer is the winged helix/Forkhead domain transcription factor FOXC2. We have previously shown that FOXC2 is necessary and sufficient to promote …
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The Role of The Epithelial-To-Mesenchymal Transition (Emt) In Lung Cancer Progression
… the leading cause of cancer-related deaths due to conventional therapy resistance and metastatic disease, therefore understanding the mechanisms governing these biological functions is vital for improving patient survival. Approximately 30% of patients with the adenocarcinoma histologic subset …
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Relationship between Processing Body Formation, Epithelial-to-Mesenchymal Transition, and Invasion in Lung Adenocarcinoma
… deaths in the United States, largely due to its ability to metastasize. Epithelial-to-mesenchymal transition (EMT) is a process that enhances the ability of cells to lose their cell-cell contacts, invade, and enter the blood stream which are essential during metastasis. Many …
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Characterising epithelial to mesenchymal transition and pro-fibrotic processes in chronic obstructive pulmonary disease
… options are limited including bronchodilators and inhaled corticosteroids that are poorly effective. Linked with a significant history of cigarette smoking, pathology is characterised by recruitment of inflammatory cells to the lung (alveolar macrophages, neutrophils and lymphocytes: TH1 …
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Functional contribution of epithelial to mesenchymal transition program on KRASG12D targeting efficacy in pancreatic cancer
<p><strong>Functional contribution of epithelial to mesenchymal transition program on KRAS<sup>G12D</sup> targeting efficacy in pancreatic cancer</strong></p> <p>Ana S. Maldonado, BS</p> <p>Advisory Professor: Raghu Kalluri, M.D., Ph.D. </p> <p>Pancreatic Ductal Adenocarcinoma (PDAC), a highly …
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Deciphering The Roles of Δnp63 In Regulating Epithelial to Mesenchymal Transition, Cancer Progression and Metastasis
… multiple isoforms that can be categorized into two main isoforms, TAp63 and ΔNp63, which are expressed in different cellular compartments and have distinct functions in many biological processes. While the Flores laboratory identified TAp63 as a tumor and metastasis suppressor, the precise …
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The role of sphingosine-1-phosphate in the epithelial to mesenchymal transition in cancer cells
… (S1P) is a bioactive lipid that has been shown to regulate hallmark cancer characteristics, one of which is Epithelial to Mesenchymal Transition (EMT). EMT is the mechanism by which an epithelial cell gains the motility to migrate throughout the body by shifting from a stationary epithelial …
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Investigating the properties of cancer stem cells and epithelial to mesenchymal transition in human prostate cancer
… model of cancer progression. Contrary to the clonal evolution model, the cancer stem cell hypothesis postulates that, akin to normal tissues, tumours are hierarchical and only a rare subpopulation of cells, so-called “cancer stem cells” (CSCs), possess the unique biological properties …
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The transcription factor grainyhead-like 2 is a novel suppressor of the epithelial to mesenchymal transition
The epithelial to mesenchymal transition (EMT) is a process that is essential for normal embryonic development as well as the healing of damaged adult tissues. In the context of cancer, oncogenic EMT induces enhanced invasion, survival and tumorigenicity which can promote disease progression and …
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Internally Translated Cx43 Isoform GJA1-20k Affects Epithelial to Mesenchymal Transition and Metastatic Cancer Cell Behavior
Epithelial-mesenchymal transition (EMT) is a trans-differentiation program essential for development and wound healing that is pathologically activated during cancer progression. During this process, cells undergo complex changes at the transcriptional and translational levels leading to …
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Induction of epithelial to mesenchymal transition in mesothelial cells by secreted factors from uterine epithelial cells
Made available in DSpace on 2012-05-22T00:30:00Z (GMT). No. of bitstreams: 2 Masoud_Farzaneh.pdf: 34313918 bytes, checksum: e99d6869329b04b746cc82321b8f70bc (MD5) license.txt: 4065 bytes, checksum: 032671e283e8d231a619ff8c90294786 (MD5)
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Role of Substrate Stiffness on Migratory Properties and Epithelial to Mesenchymal Transition in Human Lung Cancer Cells
… and innumerable research efforts are dedicated to studying the attributes of cancer to develop effective therapies. The mortality rate increases significant when the primary tumor begins to metastasize to different parts of the body. For example, women with localized breast cancer have a 93% …
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An examination of the relationship between epithelial to mesenchymal transition and cancer stem cells in solid tumors
This thesis examines the connection between epithelial to mesenchymal transition (EMT) and cancer stem cells (CSC) in solid tumors. Epithelial to mesenchymal transition describes the conversion of cancer cells from an adherent, differentiated, and polar phenotype (epithelial) to a motile, plastic, …
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Analysis of lipid metabolism regulators in breast cancer cells after induction of the Epithelial to Mesenchymal Transition
… of tumor metastasis is often enabled by the epithelial-mesenchymal transition (EMT), a key developmental program that is often activated during cancer invasion and metastasis. During the EMT process, cells undergo phenotypic changes, lose of E-cadherin expression and acquire invasive …
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Epithelial to Mesenchymal Transition As A Predictor of Response to Polo-Like Kinase 1 Inhibition-Induced Apoptosis In Non-Small Cell Lung Carcinoma
… kinase 1 (PLK1), involved in the regulation of mitotic processes and the response to DNA damage, is overexpressed in NSCLC. Inhibiting PLK1 may be an effective treatment for NSCLC patients as it is involved in the mechanisms of resistance to several chemotherapy drugs. PLK1 inhibition or …
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In vitro investigation of the effect of disulfiram on hypoxia induced NFκB, epithelial to mesenchymal transition and cancer stem cells in glioblastoma cell lines
Glioblastoma multiforme (GBM) is one of the most aggressive and lethal cancers with a poor prognosis. Advances in the treatment of GBM are limited due to several resistance mechanisms and limited drug delivery into the central nervous system (CNS) compartment by the blood-brain barrier (BBB) and by …
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Regulation and Function of Zeb1 Acetylation In Lung Adenocarcinoma Progression and Metastasis
… mortality in the United States and worldwide. Epithelial-to-mesenchymal transition (EMT) is a model for metastasis that results in loss of specialized epithelial cell contacts and acquisition of mesenchymal invasive capacity. Zinc finger E-box-binding homeobox 1 (ZEB1) recognizes and binds to …
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