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Showing 1 to 15 of 15 for “"Epigenetik"”.
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Epigenetic repression of the NFATc1 transcription factor in human lymphomas
We examined the regulation of NFATc1 in different lymphomas and observed an inversed correlation between the methylation status and expression of NFATc1. Our data demonstrate that aberrant DNA methylation associated with chromatin remodeling within nfatc1 locus is a major mechanism for the …
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Hypermethylierung-assoziierte Dysregulation der WNT-Antagonisten SFRP 1, 2, 4 und 5 beim Multiplen Myelom
There is increasing evidence that epigenetic changes, especially DNA methylation affecting promoter-associated CpG islands, play an important role in the pathogenesis of hematopoietic malignancies. In this study, we detected simultaneous hypermethylation of multiple WNT inhibitors in both MM cell …
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Zur epigenetischen Inaktivierung der Wnt-Antagonisten SFRP-1, -2, -4 und -5 bei der Akuten Myeloischen Leukämie
Acute myeloid leukaemia (AML) originates in the transformation of hematopoietic stem cells, leading to clonal proliferation of immature progenitor cells and severe multilineage bone marrow suppression. In addition to numerous genetic aberrations in AML, it has become evident that epigenetic …
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Analysis of an epigenetic regulator in mouse embryonic stem cell self-renewal and differentiation
Mammals have two orthologs, Mll and Trx2, for the Drososphila protein Trithorax (TRX), which is the founding member of the trithorax group (TrxG) of epigenetic regulators. TrxG proteins are characterized by an evolutionary conserved SET domain. A major function of all SET domain- containing …
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Untersuchung zu (epi)genetischen Veränderungen auf Chromosom 11p15 und ihre funktionelle Relevanz bei Patienten mit Silver-Russell-Syndrom
Silver-Russell syndrome (SRS) is a heterogenous syndrome which is mainly associated with severe intrauterine and postnatal growth retardation. Typical facial dysmorphisms and further characteristic symptoms can additionally be observed. So far the clinical diagnosis can not be confirmed in all …
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Die C 4 -spezifische Phosphoenolpyruvatcarboxylase in Zea mays L.: Modellsystem zur Signaintegration auf Chromatinebene in Pflanzen
Multiple internal and external stimuli act on the transcriptional activity of the C4-specific isoform of phosphoenolpyruvate carboxylase (C4-Pepc) and have to be integrated into a single promoter response. Therefore, C4-Pepc is a perfect candidate to investigate signal integration on the chromatin …
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Aberrante DNA-Methylierung des Transkriptionsfaktors C/EBP[alpha] bei akuter myeloischer Leukämie
Based on the role of epigenetic changes as an alternative mechansim of transcriptional inactivation of cancer-related genes in hematopoietic malignancies as well as the relevance of CCAAT/enhancer binding protein alpha (C/EBP alpha) in early stages of myeloid differentiation and regulation we …
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Einfluss von Histonmodifikationen auf die gewebespezifische Transkription C 4-spezifischer Gene in Mais (Zea mays)
The regulation of C4-specific genes is influenced by many internal and external stimuli that are easily manipulated. Thus, C4-genes are good candidates to investigate signal integration on the chromatin level. Recent studies that focused on the C4-specific Pepc-gene revealed a complex promoter …
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Untersuchungen über Veränderungen des Epigenoms bei der chronischen lymphatischen Leukämie
Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. Apart from chromosomal alterations comprising deletions and numeric aberrations there is increasing evidence that epigenetic processes contribute to the malignant phenotype of CLL. There is no known pathogenic …
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Investigations into the regulation of histone H2B monoubiquitination
Transkriptionsassoziierte Chromatinmodifikationen spielen eine wichtige Rolle bei der Reglation der Genexpression. So konnte die Mono-Ubiquitinierung des Lysinrestes K120 von Histon H2B (H2Bub1) beispielsweise mit transkriptionell aktiven Genen in Verbindung gebracht werden. Zum einen konnte …
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Bluttest statt Mammografie-Sreening?
Die Disputation beschäftigt sich mit der Frage, ob methylierungsbasierte Bluttests zukünftig eine Ergänzung oder teilweise Alternative zur klassischen Mammographie darstellen könnten. Im Mittelpunkt stehen epigenetische Veränderungen beim Mammakarzinom, insbesondere DNA-Methylierungsmuster, die …
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Die Regulation der humanen H3-Histongene
Ziel der vorliegenden Arbeit war es, die Transkriptions-Regulation der 11 humanen replikationsabhängig-exprimierten H3-Histongene aufzuklären und Beziehungen zur in vivo-Expression der Gene zu untersuchen. Im ersten Teil der vorliegenden Arbeit wurde die in vivo-Expression der 11 H3-Histongene in …
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Implementierung hochauflösender molekulargenetischer Methoden zur Klärung der Pathophysiologie des Silver-Russell-Syndroms
Silver Russell syndrome (SRS; OMIM #180860) is a clinically and genetically heterogeneous imprinting disorder characterized by severe pre- and postnatal growth retardation, a relative macrocephaly, a triangular face, asymmetry of the body and/or the limbs, and a clinodactyly of the fifth digits. A …
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Identifizierung und Charakterisierung von neuen DNA-Methylierungs-Biomarkern für das humane Mammakarzinom
Molecular biomarkers, being capable of detecting the earliest forms of a malignancy or predicting the course of a cancer disease are of constantly growing interest in modern medicine. Such biomarkers will be useful in early cancer diagnosis, as well as in the prediction of a tumor’s response to a …