Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Epigenetic age"”.
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Cell-type-specific responses to DNA damage from acute and chronic radiation
It is well understood that radiation causes damage to DNA, which triggers a DNA-damage response often centred on the signalling pathways of ATM, with the subsequent involvement of proteins such as p53, p21 and H2AX. Many experiments have been performed with cell lines derived from different origins …
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Applying molecular methods to investigate potential anthropogenic impacts on ageing in a free-living bat species
… This thesis examines whether diAerences in ageing and gut microbiome between two colonies of Bechstein’s bat (Myotis bechsteinii), a long-lived woodland specialist and urban avoider are consistent with anthropogenic stress exposure. In Chapter 2, DNA methylation at age associated …
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DNA methylation: a model system for the study of ageing
DNA methylation is an important epigenetic mark spanning all of life's kingdoms. In humans, DNA methylation has been associated with a wide range of age-related pathologies, including type II diabetes and cancer. More recently, in humans, changes in DNA methylation at specific positions in the …
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Metabolic control of neural stem cell function in a patient-derived model of multiple sclerosis
… of patients eventually enter a disease stage termed progressive MS (PMS), which is characterised by a substantial failure of the main endogenous brain repair mechanism seen in the early stages of the disease. During this period, patients experience a gradual accrual of neurological …
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Genetic and epigenetic associations with child development and mental health in a South African birth cohort
… between polygenic risk scores (PRS), epigenetic age (EA) deviation, DNA methylation risk scores (MRS), and key neurodevelopmental disorders such as attention-deficit hyperactivity disorder (ADHD). However, most work has thus far been undertaken in high-income countries (HICs) with …
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Ascertainment, prediction and implications of dementia diagnosis in a study of 'healthy' cognitive ageing: the Lothian Birth Cohort 1921
In the context of an ageing global population, dementia poses a significant public health challenge. While there is no cure, understanding the risks for dementia and how these may be minimised is key to reducing the impact of the disease. As life expectancy improves, increasing proportions of the …
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EFFECTS OF NIGHT SHIFT WORK ON REPRODUCTIVE HEALTHIN A POPULATION OF HEALTHCARE WORKERS
… biologica né nell’accelerazione dell’età epigenetica. I punti di forza dello studio includono il campione relativamente ampio e adeguatamente dimensionato, la dettagliata caratterizzazione dell’esposizione al lavoro notturno e l’utilizzo della spettrometria di massa ad alta specificità …