Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 382 for “"Endpoints"”.
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Surrogate endpoints of survival in metastatic carcinoma
… examined the relationship between surrogate endpoints and OS in metastatic colorectal cancer (CRC), advanced non-small cell lung cancer (NSCLC) and metastatic breast cancer (MBC). A review of the literature identified 144 RCTs in metastatic CRC, 189 in advanced NSCLC and 133 in MBC. The …
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Hyperconvexity and endpoints in T₀-quasi-metric spaces
… begin an investigation into hyperconvexity and endpoints of T₀-quasi-metric spaces. It starts off with basic definitions and some well-known properties of quasi-pseudometric spaces. We conclude by commencing an investigation into hyperconvexity and endpoints of T₀-quasi-metric spaces. In this …
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Benzo[a]pyrene effects on Fundulus heteroclitus reproductive endpoints
Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that modulates aromatase enzyme function and, thus, potentially interrupts normal reproductive function. The aim of this study was to use a fish model, Fundulus heteroclitus, to assess whether BaP exposure adversely impacted …
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Nonparametric statistical procedures for therapeutic clinical trials with survival endpoints
This thesis proposed two nonparametric statistical tests, based on the Kolmogorov-Smirnov distance and L2 mallows disatnce. To implement the proposed tests, nonparametric bootstrap method is employed to approximate the distributions of the test statistics to construct the corresponding bootstrap …
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Labels for Anchors: The Good, the Bad, and the Endpoints
This study was designed to determine if any differences in internal consistency existed between different designs of scale anchors. The three different designs explored were properly designed scales, improperly designed scales, and endpoint only scales. Two-Hundred and thirty-five participants …
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Aligning synthetic clinical trial data with human-preferred clinical endpoints
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Design and Analysis of Toxicological Experiments with Multiple Endpoints and Synergistic and Inhibitory Effects
… Dose Tolerable Region (BMDTR) for multiple endpoints and multiple stressors studies when stressors experience no more than additive effects by adopting a Bayesian approach to compute the non-linear hierarchical model. A main concern while assessing the combined toxicological effect of …
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Characterisation of exacerbations in non-CF Bronchiectasis to establish endpoints in measuring treatment efficacy
… clinical, biochemical and microbiological endpoints to aid planning of future interventional studies. We recruited fifty-eight subjects with bronchiectasis at the Lung Defence unit (Papworth Hospital, Cambridge) and studied them in stable state (no exacerbation in the preceding four weeks) …
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Development of rate related exercise-induced myocardial ischemia and risk of selected coronary disease endpoints
… certain cardiovascular morbidity and mortality endpoints among physically active patients. Data were obtained in 1989 at three community-based cardiac rehabilitation programs from three serial GXT results in 23 paired cardiac event (CE) and non-event (NE) patients. A cardiac event was defined as …
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Growth, Efficiency and Carcass Characteristics of Two Frame Sizes of Steers Slaughtered at Fat-Constant Endpoints
The growth, efficiency and carcass characteristics of 48 Simmental crossbred steers was studied. Steers were individually fed and detailed carcass separation of fat, lean and bone was performed on all steers. The fat level in live steers was successfully determined by using a backfat probe and an …
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Search for valid surrogate endpoints: review of current evidence and development of practical strategies for surrogate evaluation
… Despite the increasing uptake of surrogate endpoints and the large number of statistical methods proposed to evaluate a surrogate, there is still no consensus on how to determine when a surrogate endpoint is acceptable. Therefore, this work aimed to address three questions. PROJECT 1: How …
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Transfer learning in small-molecule drug discovery: From physics-based in-silico scores to realistic preclinical endpoints
This dissertation presents several projects in the general area of machine learning (ML) for drug discovery. Attempts to learn from molecular datasets are often hindered by the low availability of labeled datapoints. In the context of drug discovery, this limitation becomes especially severe due to …
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Bayesian and Frequentist Approaches for the Analysis of Multiple Endpoints Data Resulting from Exposure to Multiple Health Stressors.
… some studies, researchers may observe multiple endpoints on one subject. Statistical approaches to address multiple endpoints problem can be partitioned into a dimension reduction group and a dimension preservative group. Composite scores using desirability function is used, as a dimension …
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Use of non-lethal endpoints to establish water quality requirements and optima of the Topeka Shiner (notropis topeka)
… and chloride on Topeka Shiner using non-lethal endpoints by: (1) examining N. topeka's behavioral responses to a gradual reduction in oxygen, (2) determining thermal optima at different acclimation temperatures using swimming speed, and (3) determining the onset of effect of sub-lethal levels of …
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Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease
… as well as circulating biomarkers as surrogate endpoints for clinical trials in SVD. Findings in Chapter 2 show that changes in conventional MRI markers may be more robust than in DTI markers for multicenter studies and therefore more suitable as a surrogate marker in this type of trial design. …
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Evaluation of Metabolic Endpoints for Use as Biomarkers of Exposure to Environmental Estrogens and in Bioassays of Their Activity
… the uterotrophic assay. Nevertheless, other endpoints that can be used as potential biomarkers of environmental estrogen exposure are still needed since angiotensinogen is not specific to estrogens and thus cannot be used alone.
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Growth, Efficiency and Carcass Composition of Three Frame Sizes of Hogs Slaughtered at Fat Constant or Weight Constant Endpoints
A total of 193 Hampshire sired crossbred barrows were allotted in a completely randomized design to three frame size groups (small, medium and large). Birth weight and forearm length were the criteria used in the allotment procedure. Hogs were slaughtered either at a fat constant endpoint (2.54 cm) …
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