Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"Endocrine cells"”.
-
cAMP and Calcium Interactions in Endocrine Cells
… influx of Ca<sup>2+</sup>, in both MMQ pituitary cells and α-Pancreatic cells. The specific targets for PDEs and the domains of PDEs are still unknown. Pituitary MMQ cells were used as a model to test modulation of calcium influx through the L-type calcium channel with PDE inhibitors. cAMP analogs …
-
Transcriptomic analysis of pancreatic cells in zebrafish
Pancreas is a mixed gland composed of endocrine and exocrine tissues and plays a crucial role in the metabolism of all vertebrates. The endocrine cells are mainly grouped into the islets of Langerhans and secrete distinct hormones, such as glucagon (α-cell), insulin (β-cell), somatostatin (δ-cell) …
-
Studies on aspects of the physiology and pathophysiology of pancreatic polypeptide
… which has recently been recognised in pancreatic endocrine cells. Although PP has a number of effects on gastrointestinal and pancreatic exocrine function, its physiological function has not been clarified. Studies were undertaken to elucidate four aspects of the physiology and pathophysiology of …
-
From Bud to Organ: An In Depth Analysis of the Development of the Pancreas.
… organ. Chapter 3 and Chapter 4 focus on the endocrine compartment of the pancreas. In Chapter 3, the expression of Neourogenin3, or Ngn3, a master gene regulator of endocrine fate was studied and a novel molecular correlation with the first and secondary transitions of pancreatic endocrine …
-
Rgs16 is a Pancreatic Reporter of Chronic Hyperglycemia in Diabetes
… and several family members are expressed in beta cells. Regulators of G-protein Signaling (RGS) proteins are feedback regulators of GPCRs. Their expression can be induced by GPCR or cross-talk signals to inhibit GPCR pathway, thereby indicating when and where GPCR signaling occurs. Our studies …
-
Investigating the role of the Polycomb Repressive Complex 2 in human in vitro pancreatic differentiation
The potential to use human pluripotent stem cells in regenerative medicine is an idea that continues to excite and captivate much of the science community, decades after the initial discovery of human embryonic stem cells. This interest has grown with the discovery of induced human pluripotent stem …
-
Stimulus-Section Coupling in Endocrine Cell Models
… Stimulus-secretion coupling in hormone secreting cells is a complex system of pathways that link activation of cellular processes by i.e. nutrients to the release of hormone. Stimulus-secretion coupling in the insulin secreting beta-cell is intensely researched to improve our understanding of type …
-
The Role of Microtubules in Secretion
… cell membrane in a variety of both exocrine and endocrine cells. A range of roles, from provision of the motive force to preventing presecretory movement, have been attributed to these organelles. An in vitro model system to investigate the interaction between isolated exocrine pancreatic zymogen …
-
Elucidating the Role of Cellular Architecture in the Developing Pancreas
… the events necessary in order to generate these cells in vitro for replacement therapies. Directed differentiation protocols have improved upon transitioning from 2D to 3D cultures, indicating that the 3D microenvironment in which β cells are born is critical for the acquisition of their cell …
-
Ghrelin: The Hunger Hormone that Isn't
… acid acylated peptide hormone secreted by endocrine cells in the stomach. It was first identified in 1999 and shortly thereafter shown to stimulate appetite when injected into rodents and humans. While ghrelin knockout mice have failed to show a decrease in appetite or bodyweight, the …
-
RBP-L and RBP-J Have Critical Roles in the Functioning of Two Forms of the Pancreas Transcription Factor Complex PTF1
The decision of pancreatic precursor cells to differentiate into acinar or endocrine cells is regulated by a complex network of signaling and transcription factor pathways. P48 is a tissue-specific basic-helix-loop-helix (bHLH) transcription factor, which is essential for pancreas development and …
-
Investigating the Enteroendocrine - Brain Axis: Ghrelin Cell and ECL Cell Physiology and Ghrelin Action on Mood and Complex Eating
… ghrelin, and its relationship to other gastric endocrine cells, such as the histamine producing enterochromaffin-like cell. My doctoral research encompasses multiple aspects of the ghrelin system, from physiological assessments of the ghrelin cell to evaluations of ghrelin action on …
-
Modeling Monogenic Diabetes Mody3 Using Human Pluripotent Stem Cells
… the disease. Here, we use human pluripotent stem cells (ESCs) and CRISPR-CAS9 (Clustered Regularly Interspaced Short Palindromic Repeat)/Cas9) nucleases to understand the most common form of monogenic diabetes, Maturity Onset Diabetes of the Young 3 (MODY3) caused by heterozygous mutations in the …
-
Somatic cell gene therapy for diabetes mellitus: engineering a surrogate B-cell
… explores the feasibility of manipulating somatic cells to behave as a surrogate insulin-secreting β-cells. Initial studies were conducted using mouse pituitary AtT20 cells as a model, since these cells possess an endogenous complement of enzymes capable of processing proinsulin to mature insulin. …
-
Butyrate-Induced Expression of Proglucagon: Implications for Enteroendocrine Signaling and Intestinal Growth
… and absorptive capacity, it is also the largest endocrine organ in the body. There are a number of different types of endocrine cells in the gut which have the ability to mediate nutrient-gene interactions. Of interest for this research is the L cell of the distal ileum and colon which expresses …
-
Butyrate-induced expression of proglucagon: implications for enteroendocrine signaling and intestinal growth
… and absorptive capacity, it is also the largest endocrine organ in the body. There are a number of different types of endocrine cells in the gut which have the ability to mediate nutrient-gene interactions. Of interest for this research is the L cell of the distal ileum and colon which expresses …
-
Aspectos da morfologia do intestino grosso do gambá Didelphis aurita (Wied-Neuwied, 1826) com ênfase nas células enteroendócrinas
O aparelho digestório possui função crucial no controle da homeostase energética, sendo esse mecanismo regulador atribuído, em parte, às células enteroendócrinas. Estas células representam a maior população de células produtoras de hormônios do organismo de mamíferos eutérios e atuam no controle da …
-
Understanding The Roles of Non-Homologous End Joining and P53 After Dna Damage
… cellular senescence in developing lymphoid cells, which absolutely suppressed tumorigenesis. Interestingly, these mice progressively succumb to severe diabetes. Mechanistic analysis revealed that spontaneous DNA damage accumulated in the pancreatic b-cells, a unique subset of endocrine cells …
-
Actin's role in signaling light-induced phase shifts in the mammalian circadian clock
… for the general shape and integrity of all cells. New insights into the dynamic nature of the cytoskeleton describe additional roles for actin, including synaptic plasticity in the hippocampus, regulation of hormone release in endocrine cells, and as a signaling component involved in …
-
The Role of Mouse Placental Endocrine Function on Offspring Metabolic Health
… maternal metabolism. Disturbances in placental endocrine function may lead to adverse fetal outcomes and pregnancy complications, such as gestational diabetes mellitus (GDM). The Developmental Origins of Health and Disease (DOHaD) theory suggests that adversity in prenatal and early life, …
Page 1 of 2