Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 353 for “"ESI"”.
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Koulun esi- ja alkuopetuksen yhteistyö ja sen vaikutukset
… yhteistyötä koulutoimen alaisuudessa järjestetyn esiopetuksen sekä alkuopetuksen ensimmäisen luokan välillä. Tutkimuksessani keskityin selvittämään koulun esiopetuksen ja alkuopetuksen opettajien välisiä yhteistyömuotoja sekä yhteistyön hyötyjä ja haasteita. Etukäteisoletukseni oli, että esi- ja …
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In Vitro Metabolism Study of Brevetoxins by LC-ESI-MS
<p>Brevetoxins are natural neurotoxins that are produced by "red tide" algae. In this study, brevetoxin-1 and brevetoxin-2 were incubated with rat liver hepatocytes and rat liver microsomes, respectively. After clean-up steps, samples were analyzed by liquid chromatography (LC) coupled with …
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Characterization of AP-MALDI and ESI for a differential mobility spectrometer
The following thesis entails the construction, testing, modification, and analysis of two systems that couple sample ion introduction methods with a Differential Mobility Spectrometer (DMS). The sample ionization methods used with a custom designed interface for the DMS were Electrospray Ionization …
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The Characterisation of Oilfield Chemicals by Electrospray Ionization Multi-Stage Mass Spectrometry (ESI-MSᵑ)
A diverse range of polar organic chemicals used during the offshore production of crude oils is routinely discharged from oil production platforms in so-called Produced Water (PW). The environmental fate of these chemicals is largely unknown since few methods exist for their detection. In the …
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ANALYSIS OF PHARMACEUTICALS AND BIOMOLECULES USING HPLC COUPLED TO ICP-MS AND ESI-MS
The work described within this thesis explores the use of HPLC coupled with ICPMS and ESI-MS in order to develop novel methods which overcome specific analytical challenges in the pharmaceutical industry. A membrane desolvation interface has been evaluated for coupling high performance liquid …
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LC-ESI-MS/MS quantification of hair cortisol, cortisone and DHEA in combined oral contraceptive users
… of stress-related illnesses, including insulin resistance and hypertension, it is believed that these adverse effects are a result of chronic biological stress from long-term COC use and that COC users are at greater risk of developing stress-related illnesses. Different combinations of estrogens …
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Metabolic Studies on 1-Cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridinyl Derivatives by HPLC and LC-ESI/MS
… ionization mass spectrometry (LC-ESI/MS) based methods have been developed for metabolite detection and characterization. From the UV spectral data and pseudomolecular ion species observed by LC-ESI/MS, we have identified N-oxide, C-hydroxylated, and pyridinium metabolites. For the …
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" Vieläkö varhaiskasvatuksessa ja esiopetuksessa täytyy 'tunkea' digiä joka paikkaan" : Esi- ja alkuopetuksen opettajien näkemyksiä digitaalisten taitojen opettamisesta
… tarkastellaan digitalisaation tuomia vaikutuksia esi- ja alkuopetukseen. Tutkimuksen tehtävä on selvittää, miten merkityksellisenä digitaalisten taitojen opettaminen koetaan sekä minkälaisia digitaalisia taitoja tulisi opettaa jo esikoulussa, jotta lapsen siirtymä esiopetuksesta kouluun olisi …
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Detection of human salivary α-Defensins by LC-ESI-MS and evaluation of levels in athletes after physical stress
… of this study was to optimise and validate an LC-ESI-MS method to determine the level of individual human neutrophil alpha defensins (HNP1-4) after physical stress. A method for the analysis of individual (HNP1-4) in a saliva matrix by LC-ESI-MS has been established. An Agilent 1200 series HPLC, …
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The Impact of Corporate Social Responsibility on Sustainable Development: An Assessment of the Electricity Supply Industry (ESI) Corporations in Namibia
… within Namibia's Electricity Supply Industry (ESI). The primary objective of this study is to evaluate the alignment of CSR practices with national development objectives and the United Nations Sustainable Development Goals (SDGs), highlighting their role in fostering social equity, …
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GLYCOPEPTIDE ANALYSIS OF HIV-1 ENVELOPE PROTEIN USING HPLC/ESI-FTICR MS AND MALDI-TOF MS WITH ASIALOFETUIN ENRICHMENT AND SEPARATION TECHNIQUES
… the protein are favorable regions for vaccine design. Another study was performed to aid in the glycosylation analysis of the HIV-1 proteins. Asialofetuin was used as a model protein to scrutinize the separation efficiencies of three various capillary columns. Specifically the separation of …
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Enhanced Electrospray Ionization for Mass Spectrometry and Ion Mobility Spectrometry
Electrospray ionization (ESI) has become one of the most commonly used ionization techniques for mass spectrometry (MS) and ion mobility spectrometry (IMS), and efforts continue to improve its performance. ESI-MS is most recognized for its wide application to biomacromolecules where high …
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A Simulation-Based Approach for Optimal Nurse Scheduling in an Emergency Department
… Specifically, patients are divided into five ESI levels, where ESI-1 patients are the most serious and ESI-5 patients are the least serious, and waiting times are provided for each patient type. While the DSS approach is useful in generating specific working schedules that are acceptable to …
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Mechanistic Insights into Analyte Charge Enhancement using Mass Spectrometry and Molecular Dynamics Simulations
Electrospray ionization mass spectrometry (ESI-MS) is a powerful technique to investigate proteins and many other analytes. However, many fundamental aspects of ESI remain poorly understood. In this thesis, we use a combination of molecular dynamics (MD) simulations and experiments to gain insights …
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Laser ablation sample transfer for mass spectrometry
… surface. For off-line electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) analysis, the ablated material was captured in a static solvent droplet that was deposited on a MALDI target or flow-injected into a nanoelectrospray source. The direct analysis of …
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Advancing the characterization of glycan dynamics with in-electrospray ionization hydrogen/deuterium exchange-mass spectrometry.
… carbohydrates. In-electrospray ionization (in-ESI HDX-MS) enables rapid labeling and can be applied to study the solvated states of metal-adducted carbohydrates. The goal of this work is to develop in-ESI HDX-MS methods to study carbohydrate dynamics and structures. In Chapter 2, ESI droplet …
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