Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 87 for “"ERα"”.
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Proteomic characterisation of Estrogen Receptor (ERα) interactome in breast cancer
… It has been shown that estrogen receptor alpha (ERα) contributes to tumour formation in 75% of breast cancer cases and various drugs, such as 4-hydroxytamoxifen (OHT), have been used to inhibit estrogen-induced signals. Studies have highlighted the importance of interactions between ERα and …
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Cell Cycle Regulatory Roles of Estrogen Receptor Alpha (Erα) In Breast Cancer Cells
… studies have shown that Estrogen Receptor alpha (ERα) is an important indicator for diagnosis, prognosis and treatment of breast cancers. However, the question remains as to the role of ERα in the cell in the presence versus absence of 17-β estradiol In this dissertation the role of ERα in both …
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Chronic cadmium exposure alters ERα dependency and drug sensitivity of breast cancer cells
… that interact with estrogen receptor alpha (ERα) have been shown to play a role in breast cancer etiology. Evidence from epidemiological studies and animal models has suggested that cadmium, a heavy metal that can activate ERα, contributes to the development and progression of breast cancer. …
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Regulation of SRC-3 localization and dynamics by phosphorylation during ERα-dependent transcriptional activation
Transcription is controlled by promoter-selective transcriptional factors (TFs), which bind to cis-regulatory enhancers elements, termed hormone response elements (HREs), in a specific subset of genes. Regulation by these factors involves either the recruitment of coactivators or corepressors and …
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Novel insights into the molecular mechanisms of endocrine resistance in ERα positive breast cancer
ERα transcriptional activity drives tumour development and metastasis in more than 70% of breast cancer cases. Tamoxifen is the most widely and successfully used endocrine treatment for pre-menopausal women with ERα positive breast cancer. However, subgroups of patients are resistant to this drug. …
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Analyse molekularer Mechanismen der ERα- und ERβ-vermittelten Wirkung spezifischer Liganden und des Phytoestrogens Genistein
… die Bedeutung der Estrogenrezeptorsubtypen ERα und ERβ bei der Gewebehomöostase in Knochen und Darm analysiert werden. Darüber hinaus sollten vor dem Hintergrund estrogenrezeptorsubtypspezifischer Wirkungsweisen gewebespezifische Einflüsse des Phytoestrogens Genistein (Gen) näher …
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The Kras/Mapk Pathway and Ligand Independent Activation of Erα: Implications For The Treatment of Endometrial Cancer
… Ras/MAPK pathways activate estrogen receptor α (ERα) independent of estrogen, however, few studies have evaluated the role of the Ras/MAPK pathway in predicting response to hormonal therapy in EC. The aims of this project were to evaluate the role of ligand independent activation of ERα in EC and …
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The role of ERα in the uterus during embryo implantation and in the ovary during ovarian tumorigenesis
The molecular actions initiated by the steroid hormone estrogen elicit a multitude of biological effects in physiological and pathophysiological processes. Estrogen acts via its cognate steroid hormone receptor, estrogen receptor alpha (ERalpha) or beta (ERalpha, to fulfill these biological …
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Phosphorylation of ERα and HIF-1α in breast cancer with focus on tamoxifen response and links to kinase activation
Anti-oestrogens are commonly used in adjuvant breast cancer treatment and for a long time tamoxifen has been the main endocrine treatment. Patients who are eligibly for endocrine treatment are selected by the tumour-specific expression of oestrogen receptor (ER) and approximately 70 % of all breast …
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Die Effekte des ERα -Agonisten ZK 281471, dem ERß-Agonisten ZK 281738 auf das Mammagewebe der Sprague-Dawley-Ratte
… wurden die Einflüsse der Testsubstanzen (ERα-Agonist ZK 281471, ERß-Agonist ZK 281738) in verschiedenen Einzeldosen sowie in Kombination mit dem Antiöstrogen ICI 182,780 auf das Mammagewebe der Sprague-Dawley-Ratte untersucht. Anhand histologischer Schnitte, die mit Hämatoxylin und Eosin …
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The role of human DEAD-box protein DDX3X in the activation and function of Estrogen Receptor-alpha
… to phosphorylate Estrogen receptor alpha (ERα) at Serine-167 and drive expression of ERα-responsive genes in an estrogen- independent manner, leading to cell proliferation and resistance to anti-estrogen treatment. The current study aimed to investigate whether DDX3 and IKKɛ also …
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Cross-modulatory Actions of Cell Cycle Machinery on Estrogen Receptor-alpha Level and Transcriptional Activity in Breast Cancer Cells
… blocks gene expression through estradiol bound ERα, and hence the growth stimulatory effects of estradiol, has been widely used for decades for treating patients with ERα positive or hormone dependent breast cancer. Despite its obvious benefits, in as high as 40% of the patients receiving …
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Identifying new actions of estrogen receptor targetable with small molecules
Estrogens, acting via estrogen receptor α (ERα), stimulate the proliferation and metastatic potential of breast cancers, and likely some ovarian, endometrial, and cervical cancers. Endocrine therapy targeting these cancers often leads to development of resistance. Ovarian cancers do not respond to …
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Phosphorylation of the Estrogen Receptor Alpha (ERα) at Serine 118 by Phospho-p44/42 MAPK and Regulation by Estrogen and Progesterone in Human Uterine Leiomyoma Tissue and Cells
… by the interaction of estrogen receptor alpha (ERα) and growth factor pathways and that phosphorylation of ERα at serine 118 (ERα-phospho-Ser118) is important in this interaction. In tissue, immunoblotting and immunohistochemistry were used to investigate the expression of ERα-phospho-Ser118, …
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Circadian modulation of the estrogen receptor alpha transcription
… The expression of estrogen receptor alpha (ERα) mRNA oscillates in a 24-hour period and, unlike Per2, ERα peaks during the light phase of the day. Because up regulation of ERα relates to tumor development, defining the mechanisms of ERα expression will contribute to our comprehension of …
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An integrated network of estrogen receptors alpha and beta, and coregulators, for deciphering estrogen signaling in breast cancer cells
The nuclear hormone receptors, ERα and ERβ, are known to regulate the transcriptional response programs of their target cells, including breast cancer cells. However, their comparative abilities to localize at chromatin binding sites across the genome, and the recruitment of major coregulators such …
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HEPATIC ESTROGEN RECEPTOR ALPHA ACTS AS A MOLECULAR TIMER ALIGNING LIVER METABOLISM TO PREGNANCY PROGRESSION
… attraverso il recettore degli estrogeni α (ERα). ERα regola con precisione il metabolismo del fegato in relazione alle esigenze riproduttive e alla disponibilità di nutrienti. Questa regolazione potrebbe raggiungere il massimo grado di complessità durante la gravidanza, quando ERα epatico …
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Mechanisms of Estrogen-Dependent Dendrogenesis in Motoneurons of the Spinal Nucleus of the Bulbocavernosus
… bulbocavernosus, BC). I have demonstrated that ERα expression in BC extra-muscle fiber cells defines the critical period for estrogen-dependent SNB dendrite growth, and estradiol treatment during ERα expression in these extra-muscle fiber cells fully masculinizes SNB dendrites. Further, BC ERα …
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Estradiol regulation of leucine-rich repeat immunoglobulin-like domains protein 1 (LRIG 1) and roles of estrogen receptor in translational regulation in breast cancer cells
… of three proteins: the Estrogen Receptor α (ERα), the Progesterone Receptor (PR) and Heregulin 2 (HER2). The ER, though often considered responsible for driving tumor growth, is usually indicative of a good prognosis as ER-positive tumors are typically more indolent in nature and responsive …
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The anticipatory unfolded protein response and estrogen receptor mutations in breast cancer
Estrogen, acting via estrogen receptor α (ERα), stimulates cancer cell proliferation and metastasis. Endocrine therapy targeting E2:ERα activity often leads to development of antiestrogen resistance. Approximately 30% of patients who have metastatic endocrine therapy resistant breast cancer express …
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