Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 115 for “"EC50"”.
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Functional characterisation of aphid, Myzus persicae, nicotinic acetylcholine receptors and identification of a novel biogenic amine-gated ion channel from the honeybee, Apis mellifera
… to be expressed and characterised with an EC50 for acetylcholine of 123 µM. The Drosophila melanogaster α1 and Myzus persicae β1 subunits formed a functional nAChR with an EC50 for acetylcholine of 91.1 µM, upon which neonicotinoids acted as partial agonists. The Apis mellifera, European …
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Herstellung und Charakterisierung eines anti-HIV-Inhibitors basierend auf modifiziertem Serum Albumin
… (R5-gp120). Es ergab sich aus den Versuchen eine EC50 von circa 10 mg/ml (150 nM) bzw. eine EC50 von circa 25 mg/ml (370 nM) für das X4-trope bzw. R5-trope gp120. In einem HIV-1-Infektionsversuch (500 TCID50 je Virus) zeigte VEBP vollständige Inhibition der Virus-induzierten Synzytienbildung. Es …
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Intravenous anaesthetics inhibit nicotinic receptor-induced membrane currents and Ca 2+ -transients in rat intracardiac neurons
… of clinically relevant concentrations (clinical EC50) of the i.v. anaesthetics studied. In fura-2 loaded neurons, nAChR activation evoked a transient increase in [Ca2+]i, which was reversibly inhibited by the clinical EC50 of the i.v. anaesthetic thiopental. The EC50 for thiopental inhibition of …
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Functional Roles of A1-adrenergic Receptors in the Bovine Inferior Alveolar Artery: Regulation of Contraction and Activation of Extracellular Signal Regulated Kinase
… 3 pM caused relaxation of ring segments with an EC50 = 0.10 + 0.02 pM, while concentrations greater than 3 pM caused contraction. CGRP was a full agonist for vasodilation with an EC50 = 0.30 ± .02 pM, and relaxed the arteries via a non-nitric oxide, endothelium-independent mechanism. CGRP8-37 …
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Wirkungen von Ethanol auf das Phosphoinositid-Ca2+-second messenger System in Granulozyten von Patienten mit Alkoholabhängigkeit und gesunden Kontrollen
… Dosis-Wirkungs-Kurven mit signifikant erhöhten EC50-Werten bei unveränderten Delta Ca2+max- und Ca2+basal-Werten. Dies entspricht einer verminderten Sensitivität des IP-Ca2+-SMS bei akuter Alkoholexposition. Bei den Patienten zeigten sich stadienabhängige Effekte. Bei aktivem Trinken …
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Design, Synthesis, and Structure-Activity Relationship Investigation of Selective Sphingosine Kinase Inhibitors
… evaluated in a yeast cell assay to determine EC50 values. The U937 cell line and mice model were utilized for hit compounds to quantify S1P reduction in vitro and in vivo. Our preliminary results indicated compound 2.14d was the best hit discovered, with 88% SphK1 inhibition at 1 μM. In …
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Fate and Transport of Endocrine Disrupting Compounds during Wastewater Treatment: The Role of Colloidal and Particulate Material
… E2 was quantified by comparing the EC50 values of the dose-response curves generated in the presence and absence of size fractionated COC. An increase in EC50 values as a function of COC concentration was attributed to a reduction in bioavailability of E2, suggesting that …
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Phytophthora nicotianae: Fungicide Sensitivity, Fitness, and Molecular Markers
… were highly resistant to mefenoxam with a mean EC50 value of 326.5 µg/ml while the remaining 70 were sensitive with an EC50 of <0.01 µg/ml (Label rate: 0.08µg/ml). All resistant isolates were recovered from herbaceous annuals and irrigation water in 3 Virginia nurseries. Resistant isolates were …
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Effects of exposure to 17α-ethynylestradiol during larval development on the African clawed frog (Xenopus laevis) and the wood frog (Rana sylvatica)
… tested, so it was not possible to calculate an EC50 for complete feminization. The EC50 for partial feminization was determined to be approximately 8.81 µg EE2/L. At the molecular level, exposure of X. laevis to EE2 resulted in alterations in abundances of transcripts of genes involved in …
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Fungicide Sensitivity of Erysiphe necator and Plasmopara viticola from Virginia and nearby states
… populations; the resistance factor (median EC50 of the entire isolate collection divided by median EC50 of sensitive subgroup) was highest for tebuconazole (360) and myclobutanil (350), followed by triflumizole (79), triadimefon (61), and fenarimol (53). Sensitivities to all five DMI …
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Effect-site consentration of remifentanil for nasotracheal versus orotracheal intubation during propofol target-controlled infusion
… or good intubating conditions. Results: EC50 ± SD of remifentanil in the OT and NT groups was 5.58 ± 0.75 ng/ml and 6.08 ± 0.75 ng/ml, respectively; there was no statistical significance between the groups (P = 0.277). Using isotonic regression, EC50 (95% CI) of remifentanil in the OT and …
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Evaluation of race population distribution, fungicide sensitivity, and fungicide control of Exserohilum turcicum, the causal agent of northern leaf blight of corn
… at which 50% of the fungal growth was inhibited (EC50) for each isolate-fungicide combination. Baseline EC50 value lsmeans for metconazole, propiconazole, and prothioconazole were 0.032 µg/ml, 0.060 µg/ml, and 0.254 µg/ml, respectively. When lsmeans of EC50 values for 2009, 2010, 2011, 2012, 2013, …
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Evaluation of a Microalgal Bioassay Based on Community Level Physiological Profiling (CLPP)
… concentration for 50% growth inhibition effect (EC50) of DTAC followed the order: autotrophic (0.48 ± 0.03 mg of DTAC/L) > heterotrophic (1.46 ± 0.04 mg of DTAC/L) > mixotrophic (2.11 ± 0.06 mg of DTAC/L), whereas for DDAB, the order of inhibition was different as: heterotrophic (0.52 ± 0.02 mg …
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An in-vitro study investigating current and novel antimicrobial agents as potential topical treatments for cutaneous infections caused by bacteria, fungi and Leishmania
… (MBC), time-kill and effective concentration 50 (EC50) assays, investigating how structural modifications impacted activity against the varying membranes of each organism. Chlorhexidine and paromomycin were encapsulated in Lipodisq®, a specialised lipid nanoparticle. The efficacy of these …
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Hit to Lead Stage Optimization of Orally Efficacious β-Carboline Antimalarials
… DMAPP) in the malaria parasite P. falciparum (EC50 250 ± 70 nM, IPP rescue 100% @ 2.5 μM). Subsequent investigation revealed that (1R,3S)-configuration and 2',4'-dihalogen substitution were critical for the activity of this compound, and that substitution of the non-aromatic ring was not …
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In vitro inhibition of coronavirus replications
… We determined the 50% effective concentration (EC50) of each extract that was necessary to inhibit the replication of mouse hepatitis virus A59 (MHV-A59); we also determined 50% cytotoxic concentrations (CC50) for each extract. Northern and Western blot analyzes were performed to investigate …
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Structure-Activity Relationship Studies of Mitochondrial Uncouplers and PilB Inhibitors
… models. Our previous work identified BAM15 (EC50 1.5 M) as a potent and efficacious mitochondrial uncoupler with potential for obesity treatment. In this study, we investigate in vitro and in vivo properties of hydroxylamine and hydrazine BAM15 derivatives and reveal the high uncoupling …
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From single species to mesocosms: responses of freshwater copepods and their community to PCP
… treatment effects on each sample day. Daily EC50 estimates were calculated using total copepod % change in abundance so that effect concentrations could be compared to results from the laboratory copepod tests. In the laboratory tests, C. lucasi was the most sensitive of the three copepods …
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Ecotoxicological Investigations in Effluent-Dominated Stream Mesocosms
… (BLM) for Cd was used to predict a 48 hour Cd EC50 for Ceriodaphnia dubia of 280 µg/L in these effluent-dominated streams. This value is higher that an EC50 of 38.3 µg/L Cd and a 7-day reproduction effect level of 3.3 µg/L Cd generated for C. dubia in reconstituted laboratory hard water. These …
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Posouzení vlivů běžně používaných hasiv na vybrané složky životního prostředí
… testů byly vypočteny hodnoty IC50, LC50 a EC50, prostřednictvím kterých byl posouzen vliv jednotlivých hasebních prostředků na složky životního prostředí. Jako nejvíce toxický se ve většině testů ukázal hasební prostředek TS ECO a naopak nejméně ekotoxický se jevil hasební prášek ABC …
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