Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 101 for “"EAE"”.
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Amelioration of the chronic relapsing experimental allergic encephalomyelitis (CR-EAE) using thymoquinone
… used Experimental autoimmune encephalomyelitis (EAE) animal model that mimic human MS and tested the effect of Thymoquinone (TQ) a constituent of oil of Nigella Sativa also known as black seed. Thirty female mice strain C57BL/6J between 6 to 12 weeks of age were placed into 3 groups of 10 and MOG …
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Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
… investigated the immunobiology of MOG-induced EAE in the DA rat, an animal model, which reproduces the immunopathology of the type II MS lesion (Lucchinetti et al., 2000). A newly established immunisation protocol results in a highly synchronised biphasic form of EAE, which mimics the disease …
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M-Bromo pep, un agoniste silencieux des récepteurs nicotiniques alpha-7, module la réponse inflammatoire et protège contre l'EAE
… encéphalomyélite auto-immunitaire expérimentale (EAE), il a été démontré que les symptômes de la maladie peuvent être atténués façon importante lorsque traités avec des concentrations de nicotine assez élevées pour induire la désensibilisation des récepteurs cholinergiques nicotiniques alpha7 …
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Brain derived neurotrophic factor (BDNF): Untersuchungen zur Expression und Regulation in vitro sowie zur funktionellen Relevanz in der experimentellen autoimmunen Enzephalomyelitis (EAE)
… experimentellen autoimmunen Enzephalomyelitis (EAE). Dadurch sollte getestet werden, ob diese Injektion den Krankheitsverlauf, aber vor allem den axonalen Schaden positiv beeinflussen kann. Dafür wurden mit Hilfe eines lentiviralen Transduktionssystems BDNF überexprimierende T-Zellen generiert, …
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Cystatin C and sex dimorphism in experimental autoimmune encephalomyelitis
… called experimental allergic encephalomyelitis (EAE). MS is an autoimmune disease characterized by infiltration of myelin reactive immune cells into the central nervous system (CNS) that is more prevalent in genetically susceptible women compared to men. Alteration in the level of CysC in the CNS …
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The intersection of pain, disease severity, and circadian disruption in experimental autoimmune encephalomyelitis
… in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, with a focus on pain outcomes. However, limitations in this model led to the pursuit of novel methodology and tools in the EAE field. First, a mild induction protocol of EAE was characterized in order to improve the study …
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Investigating Potential Quantitative Trait Loci for Susceptibility to Experimental Autoimmune Encephalomyelitis in the BXD Family of Mice
… that affect a BXD strain’s susceptibility to EAE, an inducible disease model for MS. We induced EAE in several BXD mice strains via an emulsion of complete Freund’s adjuvant and MOG35-55, and then measured disease severity in each strain. From there, we measured incidence rate of EAE, average …
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Genetic and Sex Steroid Hormone Contributions to the Sexual Dimorphism in Murine Experimental Allergic Encephalomyelitis
… the composition of the adjuvant used to induce EAE had important implications on the degree of genetic susceptibility necessary to result in disease. We also found that of the many quantitative trait loci (QTL) identified to date, genetic linkages to mouse chromosomes 7 and 11 were strongly …
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Multiple Toll-Like Receptor Agonists Act as Potent Adjuvants in the Induction of Autoimmunity
… in Experimental Autoimmune Encephalomyelitis (EAE), an animal model of MS. Both genetic and environmental influences contribute to the pathogenesis of MS. I used various PAMPs as the environmental input to imitate infection and activate TLRs in an effort to induce EAE in a resistant mouse …
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Therapeutic Modulation of Experimental Autoimmune Encephalomyelitis by Gamma Secretase Inhibition
… of experimental autoimmune encephalomyelitis (EAE), presumably by affecting Notch signaling. To understand the mechanisms through which γSI alter autoimmune T cell responses, we utilized an adoptive transfer model of EAE. We found that γSI treatment in vivo reduced EAE severity after adoptive …
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Der Einfluß eines fötal exprimierten Autoantigens auf die Induktion von Autoimmunität während der Schwangerschaft
… entwickelt werden. Als Autoimmunkrankheit wurde EAE (Experimentelle Autoimmune Enzephalomyelitis) als Tiermodell für Multiple Sklerose ausgewählt. Es wurden transgene Mäuse entwickelt, die das Autoantigen Myelin Basic Protein 1-10, kovalent gebunden an MHC Klasse II exprimieren. Die Transgene, …
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Investigating the protective effects of farnesol formations against neuroinflammation
… experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. We demonstrate that there is a correlation between reduced neuroinflammation and EAE severity observed in the context of FOL protection. We compared the progression of EAE in MOG35-55 immunized female …
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Transcriptional Regulation of T Helper Cell Differentiation in Autoimmunity
… and effector function of T helper cells in the EAE model. Based on its ability to induce a pro-inflammatory immune response, T-bet has been found to regulate genes that have been directly linked to pathogenicity in EAE/MS. We examined the use of T-bet specific AS oligonucleotides and siRNA to …
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Inflammatory astrocyte and T cell interactions are supported by hyaluronan in a murine model of Multiple Sclerosis
… the experimental autoimmune encephalomyelitis (EAE) model of MS. Using this model and in vitro cultures of astrocytes, I identified a novel cell surface marker to identify inflammatory astrocytes. By flow cytometry and confocal microscopy, I determined that the frequency of inflammatory …
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Novel Immunotherapies and Immunoregulation in a Chronic Inflammatory Disease of the Central Nervous System
… the Experimental Autoimmune Encephalomyelitis (EAE), as a mouse model for MS. Chronic EAE was induced by immunization with the myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide. MOG-reactive inflammatory CD4+ T cells infiltrate the CNS and, in concert with other mononuclear cells, cause …
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Autoregulatory CD8 T-Cells Modulate CNS Autoimmune Disease by Targeting Encephalitogenic CD4 T-Cells
… MS, experimental autoimmune encephalomyelitis (EAE), we are currently evaluating the role of these poorly studied myelin antigen-specific CD8 T-cells in the context of this autoimmune disease. We have observed that myelin oligodendrocyte glycoprotein peptide (MOG₃₅₋₅₅)-specific CD8 T-cells do …
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RAPID COLORIMETRIC IDENTIFICATION OF ESCHERICHIA COLI SHIGA TOXINS 1 AND 2, AS WELL AS EAE AND AGGR, USING LOOP MEDIATED ISOTHERMAL AMPLIFICATION FOLLOWED BY PNA/AUNP DETECTION
… to either the Shiga toxin 1 or 2 genes, <em>eae</em> or <em>aggR</em> was introduced, along with gold nanoparticles (AuNP). The PNA-AuNP detection system does not depend on pH change, rather an aggregation or monodispersing of gold nanoparticles that is sequence specific. When the PNA probe …
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