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Showing 1 to 20 of 136 for “"Dsb"”.

  1. 53BP1/Shieldin Counteract DSB Resection Through Fill-In Synthesis

    Mirman, Zachary Kenneth

    … The role of 53BP1 in double strand break (DSB) repair outside of these three well-studied contexts is less clear, though it has been proposed that 53BP1 acts as a master regulator of so-called "DSB repair pathway choice," promoting classical non-homologous end-joining (cNHEJ) at the expense …

    rockefeller Repository record

  2. Aza-analogues of distyrylbenzene (DSB) synthesis, structures, and properties of 1,4-phenylenediamine bisimines (PDABI)

    Murphy, Richard F., IIIUniversity of Missouri--Columbia2006

    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The drive for electo-optically active materials was officially initiated in 1966 with the publishing, by NASA, of a 137 page report. The "Electro-optic Projection Study" outlined the advantages of optical processing over those …

    missouri Repository record

  3. Conversor DSB-SSB a capacitores chaveados por transformador de Hilbert em tecnologia CMOS de 180 nm

    Lacerda, Fábio deUniversidade Federal do Rio de Janeiro2017

    … circuit for conversion of Double-Sideband (DSB) amplitude-modulated signals into Single-Sideband (SSB) is presented. Implemented by discrete-time switched-capacitor circuits, it adopts an Infinite Impulse Response (IIR) filter to realize a Hilbert transformer as alternative to digital …

    brazil-uerj Repository record

  4. Proteomic Identification of Histone Post-Translational Modifications Induced By Dna Double-Strand Breaks and Novel Proteins Involved In The Dna Damage Response

    Wang, Pingping, <p>0000-0001-6203-5725</p>2018

    <p>Inaccurate repair of DNA double-strand breaks (DSBs) can lead to DNA mutation and chromosome rearrangements, causing human diseases such as cancer. Although we know the basic mechanisms of DSB repair, the added complexities in the chromatin context are unclear. This is partially due to the lack …

    uthsc Repository record

  5. The WTO’s Dispute Settlement Body and its impact on Developing Countries: problems and possible solutions.

    Alotaibi, NaifUniversity of Essex2015

    … Organization’s (WTO) Dispute Settlement Body (DSB). Under the DSB, there are many cases that present the limiting of developing countries on some significant ways. This thesis discusses the most significant limiting factors reported and practiced by developing countries in the DSB. Developing …

    essex Repository record

  6. Development of Novel Technologies to Investigate DNA Double-Strand Break Repair Uncovers a Role for the ATM Kinase in Error-Free NHEJ with Implications for Neurodegenerative Diseases

    Kruswick, Alex J.Massachusetts Institute of Technology2025

    DNA double strand breaks (DSBs) are considered to be the most lethal genotoxic lesion because they can result in chromosomal translocations or result in a major loss of genetic information if repaired incorrectly. To preserve genomic integrity, mammalian cells have evolved a set of complimentary …

    mit Repository record

  7. Mechanisms of DNA double strand break-mediated neurotoxicity in neurodegenerative disease

    Welch, Gwyneth M.Massachusetts Institute of Technology2022

    … and long lifespan. DNA double strand breaks (DSBs) are also linked to neurodegeneration and senescence. However, it is not clear how DSB-bearing neurons influence processes of neuroinflammation and neurodegeneration. Here, we characterize DSB-bearing neurons from the CK-p25 mouse model of …

    mit Repository record

  8. Studies of site-specific DNA double strand break repair in plants

    Kuang, Xianyan2010

    … and paste"” mechanism, leaving a site-specific DSB at the <i> Ds </i> locus for repair. Previous studies in maize and Arabidopsis showed that <i>Ac/Ds</i> excision can stimulate homologous recombination between tandem duplicated repeats and between ectopic homologies. In this study, we tested …

    iastate Repository record

  9. Role of NF-κB p65 subunit phosphorylation by ATM in DNA damage-regulated gene expression

    Sabatel, HélèneULiège - Université de Liège2012

    … types of DNA lesions, DNA double-strand breaks (DSB) are the most deleterious. Indeed, if not correctly repaired, they can lead to cell death or carcinogenesis. Upon DSB, cells activate a complex signaling network, the DNA damage response (DDR), to counteract those threats. The DDR coordinates …

    liege Repository record

  10. Homologous Recombination Outcomes of Double-Strand Break- initiated Events in Saccharomyces cerevisiae

    Gamble, Dionna Monique2020

    … otherwise lethal DNA double-strand breaks (DSBs) using a homologous donor template. The work in this dissertation, using the budding yeast Saccharomyces cerevisiae as a model system, focuses on the effect of the initiating DSB and sequence homology on the outcomes of repair. First, in …

    duke Repository record

  11. MIMO RADIO-OVER-FIBRE DISTRIBUTED ANTENNA SYSTEM FOR NEXT GENERATION WIRELESS COMMUNICATION

    Yang, YumengUniversity of Cambridge2018

    … over fibre (RoF) system using double sideband (DSB) frequency translation system is proposed. In such a system, the 2x2 MIMO signals can be transmitted to the remote antenna units (RAUs) from the base station via a single optical link. By using the DSB frequency translation, the original …

    cambridge Repository record

  12. Effect of Werner and Bloom Helicase Deficiencies On Dna Double-Strand Break Repair

    Smith, Krissy Lynn

    <p>DNA double strand breaks (DSBs) are very deleterious events that occur in cells. Causes can include endogenous agents such as reactive oxygen and nitrogen species, exogenous agents such as ionizing radiation and ultraviolet light, or other sources such as processing of spontaneous DNA lesions or …

    south-carolina Repository record

  13. Etablierung eines Plasmid-basierten Testsystems zur funktionellen Messung der zellulären Doppelstrangbruch-Reparaturfähigkeit in hämatopoetischen Zellen

    Hermann, Julia2012

    … der individuellen zellulären Doppelstrangbruch (DSB)-Reparaturkapazität. In unserem Testsystem wurde das Plasmid pCMVluc durch ein Enzym im Luciferasegen-tragenden Abschnitt einmalig mit glatten Enden geschnitten und mittels Gelelution aufgereinigt. Anschließend wurde das linearisierte Plasmid in …

    goettingen Repository record

  14. Shedding Light on the Biological Effects of Ionising Radiation on DNA Using Advanced Optical Microscopy

    D’Abrantes, SofiaOxford Brookes University2020

    … DNA damage (CDD) and double-strand breaks (DSBs). CDD consists of two or more lesions in close proximity, including DSBs, single-strand breaks and/or base damages. CDD complexity increases with rising linear energy transfer (LET) of radiation, while repairability decreases. This makes …

    oxford-brookes Repository record

  15. Identification and Investigation of Novel DNA Damage Repair Genes Via Network Analysis

    Potter, Taylor AlexandraCarleton University2018

    … genotoxic effect, double-stranded breaks (DSBs) are exceptional. The deleterious potential of a misrepaired DSB represents a severe threat to cellular integrity. Repair machinery defects are frequently observed in tumorigenic and oncogenic cells. General DNA damage repair mechanisms involve …

    carleton Repository record

  16. Genetic and epigenetic regulation of the cell wall glycoproteins, Flo10p and Flo11p, generate phenotypic variation in S. cerevisiae

    Halme, Adrian Jones, 1971-Massachusetts Institute of Technology2003

    … these genes, including DNA double-strand break (DSB) repair pathways. Genetic analysis demonstrates that both homologous recombination (HR) and non-homologous end-joining (NHEJ) pathways of DSB repair maintain genetic stability at the IRA loci. Since these pathways specifically process a DSB …

    mit Repository record

  17. THE DNA DAMAGE CHECKPOINT REGULATES MISMATCH REPAIR COMPLEXES DURING SINGLE STRAND ANNEALING PATHWAY

    VIETRI, MARIA YLENIAUniversità degli Studi di Milano2023

    … can be converted to DNA double-strand breaks (DSBs), which are the most dangerous form of DNA lesions. DSBs are throught to be particularly relevant because their repair is more difficult then other types of DNA damage, potentially leading to chromosome rearrangements and loss of genetic …

    milano Repository record

  18. Quantitative measurement and modeling of the DNA damage signaling network : DNA double-strand breaks

    Tentner, Andrea R. (Andrea Ruth)Massachusetts Institute of Technology2009

    DNA double-strand breaks (DSB) are one of the major mediators of chemotherapy-induced cytotoxicity in tumors. Cells that experience DNA damage can initiate a DNA damage-mediated cell-cycle arrest, attempt to repair the damage and, if successful, resume the cell-cycle (arrest/repair/resume). Cells …

    mit Repository record

  19. Understanding Host Tolerance to Transposable Elements

    Lama, JyotiUniversity of Houston2021

    … variation in the double-stranded break (DSB) repair efficiency. Tolerant genotypes show increased expression of components of the Tat interactive protein 60-kDa (TIP60) complex involved in DSB repair and also exhibited increased chorion gene expression- an indicator of enhanced DSB …

    houston Repository record

  20. Understanding The Repair Mechanisms at Ionizing Radiation-induced Damage in The Human Genome

    Dutta, ArijitThe University of Texas Medical Branch at Galveston2019

    … genome that include DNA double-strand breaks (DSB) with unligatable dirty ends, along with more frequent oxidized bases and single-strand breaks (SSB). While nonhomologous end joining and homologous recombination are major DSB repair pathways which have been extensively characterized over the …

    utmb Repository record

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