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Showing 1 to 16 of 16 for “"Digital Microfluidics"”.
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Digital Microfluidics for the Detection of Inorganic Ions in Aerosols
… for an aerosol detection system that combines digital microfluidics technology, aerosol impaction and chemical detection on the same chip. The system will be smaller and faster with respect to current aerosol analyzing instruments. The chip in this study performs the integrated functions of …
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Microfluidic Interfaces for Mass Spectrometry: Methods and Applications
… consuming and labor-intensive steps involved. Microfluidics can play an important role in proteome sample preparation due to its ability to handle small volumes of sample and reagent, and its capability to integrate multiple processes on a single chip with the potential for high-throughput …
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Surface Acoustic Wave Nebulization as a Mass Spectrometry Ionization Source, Characterization and Application
… and improvement, we combined SAWN with digital microfluidics (DMF) for sample preparation before MS detection. DMF-SAWN platform was applied to the analysis of phosphorylated protein mixture. Peptides from all three proteins of the mixture were identified with DMF-SAWN.
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Droplet manipulation on structured shape memory polymer surface
… widely explored for many applications including digital microfluidics, those based on dynamically changeable surface morphology have remained challenging to achieve. In this work, we present a structured shape memory polymer (SMP) surface which shows dynamically tunable surface wettability …
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Development of a Planar Capillary Electrophoresis device coupled with dual refractive index and fluorescence detection
… we explored methods to combine digital microfluidics with the PCE platform to integrate miniaturized sample and fluid handling. Digital microfluidics manipulate liquids in the form of small droplets (~ 2uL) on a patterned electrode surface using the electrowetting on dielectric …
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New Tools for Diagnosis and Treatment of Bacterial Infections
… tools are needed; advances in biosensing and microfluidics aim to address these limitations in conventional testing. With improvements in diagnostic testing comes the ability to administer personalized patient treatments, an area which has become increasingly explored. In wound care …
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Additively Manufacturing High-Performance, Low-Cost Electrospray Ion Sources for Point-of-Care Mass Spectrometry
… soldered to printed circuit boards with built-in digital microfluidics as part of automated device assembly. The benefits in terms of scalability of this solution are coupled with advantages gained from simultaneously tuning surface hydrophilicity, solvent evaporation, and geometry. Electrospray …
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Development of an automated and scalable lab-on-a-chip platform with on-chip characterization
Digital Microfluidics (DMF) is a fluid-handling technique that enables precise control of drops on an array of electrodes using electrostatic forces. In contrast to most other lab-on-a-chip technologies (e.g., channel-based microfluidics), DMF is highly reconfigurable (i.e., function is defined by …
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Development of conformal reconfigurable metamaterial-based antennas
… that can be reconfigured by employing microfluidics. In applications such as biomedicine, this work presents an inkjet-printed dipole antenna on flexible Kapton-foam substrate to be used on lossy host structures. The concept of Artificial Magnetic Conductor (AMC) unit cells is …
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Development of a Digital Microfluidic Lab-on-a-chip for Analysis of Atmospheric Inorganic Ions
… three major inorganic ions on a single platform. Digital microfluidics is the key technology behind the LoC. It involves the micromanipulation of discrete droplets using electrowetting. Electrowetting refers to the application of an electric field which modifies the wetting behavior of a droplet. …
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Chip Scale Integrated Optical Sensing Systems with Digital Microfluidic Systems
… functionality optical system integration with a digital microfluidics platform for medical diagnostics and environmental monitoring. </p><p>This thesis describes the details of the design, fabrication, experimental measurement, and theoretical modeling of chip scale optical sensing systems …
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Applications and Advancements of Dynamic Isoelectric Focusing
… peaks are not able to broaden. This novel use of digital microfluidics is still a work in progress, but the fundamentals have been demonstrated. The fabrication protocol for making molds and PDMS casts was developed using materials and procedures that can be done in a common laboratory …
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A Numerical Simulation Optimizing Droplet Motion Driven by Electrowetting
<p>A numerical simulation of electrowetting on a dielectric was performed in COMSOL to grant insight on various parameters that play a critical role in system performance. The specific system being simulated was the Open Drop experiment and the parameters being investigated were the applied …
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Sparse Sample Detection Using Magnetic Bead Manipulation on a Digital Microfluidic Device
… which uses magnetic bead manipulation on a digital microfluidic device. Sparse sample detection was made possible through two steps: sparse sample capture and fluorescent signal detection. For the first step, the immunological reaction between antibody and antigen enables the binding between …
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Accelerated Sepsis Diagnosis by Seamless Integration of Nucleic Acid Purification and Detection
… combining immiscible phase filtration (IPF) and digital microfluidic droplet actuation (DM) on a fluidic device. In IPF, as nucleic acid-bound magnetic beads are transported from an aqueous phase to an immiscible phase, the carryover of aqueous contaminants is minimized by the high interfacial …