Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Decidualization"”.
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Estrogen signaling during decidualization
… blastocyst in the differentiated endometrium. Decidualization, a signatory event during this process is characterized by the deciduous transformation of fibroblast endometrial stromal cells to morphologically and functionally unique decidual cells along with the formation of extensive …
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Endometrial Decidualization by TGF-β and PPAR-γ
OBJECTIVE: Endometrial decidualization is essential for implantation and pregnancy, so we investigated the interaction of TGF-β and PPAR-γ on decidualization using cultured human endometrial stromal cell. METHODS: Human endometrial tissues were examined immunohistochemically for the expression of …
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Initiation of Implantation and Decidualization in the Inbred Mouse.
Intimate contact between embryonic and maternal tissues is sine qua non for uterine development in eutherian mammals, since these species shed microlecithal eggs. The stores of nutrients (i.e. yolk) are so scanty in such an egg that independent development beyond the earliest stages cannot be …
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ROLES OF HAND2 TRANSCRIPTION FACTOR IN UTERINE RECEPTIVITY AND DECIDUALIZATION
… the endometrial tissue undergoes the process of decidualization to support the anchoring of the blastocyst and provides the blastocyst with nutrition until the fully functional placenta is formed. Although the process of implantation and decidualization are under control of progesterone and …
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Analysis of the Role of the Transcription Factor-C/ebpbeta in Implantation
… progesterone, promote a unique process known as decidualization, which involves extensive proliferation and differentiation of uterine stromal cells. The molecular pathways underlying this hormonally induced cellular transformation, an essential prerequisite for embryo implantation, are poorly …
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Analysis of the role of the transcription factor-C/EBPβ in implantation
… progesterone, promote a unique process known as decidualization, which involves extensive proliferation and differentiation of uterine stromal cells. The molecular pathways underlying this hormonally induced cellular transformation, an essential prerequisite for embryo implantation, are poorly …
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Role of Extracellular Signal-Regulated Kinase and Peroxisome Proliferator-Activated Receptor gamma on Transforming Growth Factor-β1-Induced Human Endometrial Stromal Cell Decidualization
… on TGF-β1-induced human endometrial stromal cell decidualization in vitro. MATERIALS AND METHODS: Human endometrial tissues obtained by hysterectomy specimens from patients with conditions other than endometrial diseases such as leiomyoma. Endometrial stromal cells were cultured under the …
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Expression and function of basigin during early pregnancy and spermatogenesis
… 2) whether BSG is required for HESCs decidualization; and 3) whether BSG is essential for the interactions between gametes and Sertoli cells during spermatogenesis. BSG protein was expressed in the uterine epithelium at estrus in βERKO mice but not in αERKO mice. However, a higher …
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Molecular mechanisms regulating implantation
… ESR1in the uterus during stromal cell decidualization. Earlier studies in our lab had indicated an essential role of uterine ESR1 in stromal cell decidualization. This study prompted an investigation into the compartment specific role of ESR1 in uterine stromal cell decidualization. We …
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The Effect of the Conceptus on Endometrial Angiogenesis and Immune Cell Populations During Implantation
… communication during the progression of decidualization is starting to be worked out, we still have much to learn about the precise details of the entire repertoire of the molecular signals responsible. In the rodent we still have to clearly find and define the biology of important …
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The role of Ras-related C3 botulinum toxin substrate 1 (RAC1)-dependent pathway in the regulation of uterine function during early pregnancy
… of pregnancy. Although it is clear that decidualization and angiogenesis play a crucial role during early pregnancy, the complex molecular pathways underlying these processes remain largely unknown. Our recent studies revealed that RAC1 (Ras-related C3 botulinum toxin substrate 1), a …
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Loss of basigin expression in the uterus reduces fertility in female mice
… in female mice by altering implantation, decidualization, lactate transporters and angiogenesis. In mice, global ablation of Bsg is embryonic lethal, which complicates the studies on the role of BSG in reproduction. To overcome the embryonic lethality, we generated a progesterone receptor …
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Identification of molecular signaling pathways underlying human endometrial stromal cell differentiation
Decidualization, the differentiation of endometrial stromal cells, is essential for a successful pregnancy. Although the steroid hormones estrogen (E) and progesterone (P) are known to control decidualization, the precise mechanisms via which these hormones act to control this differentiation …
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The impact of advanced maternal age on endometrial differentiation and placental development
… abnormal expression of genes involved in the decidualization process, which occurs during early pregnancy and facilitates implantation and development of the conceptus. I show that these defects are already obvious in the peri-implantation window, with endometrial stromal cells from aged …
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The role of ERα in the uterus during embryo implantation and in the ovary during ovarian tumorigenesis
… receptor (PR). By employing artificially induced decidualization we know that ERalpha in the uterine stromal cells is essential for proliferation and decidualization. To date very few molecules have been shown to be regulated by estrogen in the uterine stromal cells that are essential for …
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Role of transcription factor Runx1 in uterine stromal cell differentiation and maternal-fetal interaction during mouse pregnancy
… cells to decidual cells, a process known as decidualization, is essential for the establishment of pregnancy. The decidual tissue produces multitude of factors that control a variety of physiological processes at the fetal-maternal interface, such as endometrial vasculogenesis, modulation of …
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Role of Msx homeobox genes in uterus during embryo implantation
… Msx homeobox genes during uterine stromal cell decidualization. As the embryo attaches to the uterine wall and invades into the stromal bed, the stromal cells surrounding the implanting blastocyst differentiate into decidual cells in a process known as decidualization. This process is critical …
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Analysis of the Role of the Transcription Factor C/EBPbeta in Controlling Uterine Functions During Early Pregnancy
… stromal cell differentiation, a process known as decidualization, during pregnancy. My studies have delineated important mechanisms by which E regulates C/EBPbeta expression to induce DNA replication and prevent apoptosis of uterine epithelial cells during E-induced epithelial growth. In …
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Analysis of the role of the transcription factor C/EBPβ in controlling uterine functions during early pregnancy
… stromal cell differentiation, a process known as decidualization, during pregnancy. My studies have delineated important mechanisms by which E regulates C/EBPb expression to induce DNA replication and prevent apoptosis of uterine epithelial cells during E-induced epithelial growth. In subsequent …
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Steroid Hormone Regulation of Implantation
… is that E plays minimal role in the process of decidualization. Our studies show prominent expression of aromatase, the key enzyme involved in E synthesis, in the pregnant uterus during decidual phase of gestation. Studies in chapter II of the thesis describe the spatiotemporal expression …
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