Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"DNA-damaging agents"”.
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The Role of Prolactin in the Cellular Response to DNA Damaging Agents
… involved in prolactin induced resistance to DNA damaging agents with the hypothesis that the cross-talk between the prolactin pathway and the DNA damage response is important in the mechanism. We previously identified that one isoform of heat shock protein-90 (HSP90), Hsp90alpha, is a …
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Role of RIP3 in DNA damaging agent-induced breast cancer cell death
… is activated in response to chemotherapeutic agents and contributes to chemotherapy-induced breast cancer cell death. However, we also show that RIP3 expression is silenced in basal like breast cancer cell lines due to DNA methylation near its transcription start site. Due to this silencing …
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Effects of far ultra-violet radiation and oxygen on macromolecular synthesis and protein induction in Bacteroides fragilis Bf-2
… induced in this organism by these different DNA damaging agents.
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Novel function and regulation of mutagenic DNA polymerases in Escherichia coli
… dinB+ encode novel, low to moderate fidelity DNA polymerases with the ability to catalyze synthesis on imperfect DNA templates in a process termed translesion synthesis (TLS). Similar enzymes exist in nearly all organisms, constituting the Y-superfamily of DNA polymerases. Although DinB is the …
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Regulation of the ribonucleotide reductase small subunit gene in Dictyostelium discoideum
… providing precursors for the synthesis of DNA. Expression of ribonucleotide reductase is correlated with DNA synthesis: it is up-regulated during the DNA synthesis phase of the cell cycle and in the course of DNA repair. We have examined the regulation of expression of the ribonucleotide …
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BIOLOGICAL CHARACTERIZATION OF TWO PUTATIVE DNA METABOLISM ENZYMES IN DEINOCOCCUS RADIODURANS
… protein that translocates double-stranded DNA during cell division. In archaea, herA is an essential gene that encodes an enzyme believed to be important for recombinational DNA repair. It is typically found in an operon with a gene that codes for a nuclease, nurA. Homologs of herA and nurA …
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Characterization of two Bacillus subtilis proteins required for the initiation, restart, and control of DNA replication
(cont.) This is consistent with an inability of dnaBS371P cells to adjust the frequency of initiation according to growth rate. I also found that cells over-producing DnaBS371P are filamentous, contain decreased DNA contents, and are hypersensitive to DNA-damaging agents. These abnormalities may …
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DNA repair in Bacteroides fragilis Bf-2
… study the responses of this organism to various DNA damaging agents at the physiological and molecular levels. Two types of mutants were isolated by ethyl methane sulphonate mutagenesis of B.fragilis followed by selection for sensitivity to mitomycin C. One mutant (UVS9) showed sensitivity to …
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Focused CRISPR-Cas9 screens investigating the DNA damage response
The DNA damage response (DDR) consists of a complex network of interconnected pathways which detect and repair damaged DNA, maintaining genome integrity. Somatic mutations in DDR genes are associated with tumour development, while germline mutations cause a spectrum of disorders ranging from …
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Role of Actin and its regulating proteins in drug response
… leukaemia (ALL). Resistance to these agents can be a major clinical problem and mechanisms mediating resistance are not fully understood. Previous studies have reported an association between the actin cytoskeleton and resistance to antimicrotubule drugs. Thus, the aim of this study …
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The effect of replication impediments on differentiation
… endoderm while replication was perturbed using DNA damaging agents, low dose hydroxyurea and G-quadruplex secondary structure stabilisation. DNA damage was induced both in the undifferentiated state and during differentiation. When damage was induced during differentiation, greater levels of …
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Next-generation sequencing as a tool for investigating the in vivo biological consequences of DNA lesions and its applications on the ethenoguanine, 8-oxoguanine and 1,3-butadiene-induced lesions
DNA damaging agents produce a plethora of DNA lesions, which can lead to various outcomes. In order to understand the biological consequences of DNA lesions, and hence gain insights into the carcinogenic mechanisms of DNA damaging agents, individual lesions need to be evaluated for their genotoxic …
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Engineering a single cell microarray platform for high throughput DNA damage and repair analysis
DNA damage contributes to cancer, aging, and heritable diseases. Ironically, DNA damaging agents are also commonly used in current cancer treatment. We therefore need robust, high throughput, and inexpensive tools for objective, quantitative DNA damage analysis. The single cell gel electrophoresis …
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Rev7 is a novel regulator of chemotherapeutic response in drug-resistant lung cancer
… cancers are treated with chemotherapeutic agents that target and damage cellular DNA While genotoxic chemotherapies have proven to be highly effective agents for cancer therapy, it is well known that intrinsic and acquired cancer drug resistance is a problem that severely limits the …
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Establishing the role of RNF4 in the vertebrate DNA damage response
… elevated mutation rates, sensitivity to DNA damaging agents and also demonstrated synthetic lethality with other DNA repair genes. Although the role of vertebrate RNF4 in the DNA damage response was not yet established, it could rescue the Schizosaccaromyces pombe STUbL mutant phenotypes, …
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The Role Of Ubc9 In Drug Resistance And Its Expression Regulation In Cancer Cells
… proliferation, differentiation, stress response, DNA repair and apoptosis. Given the important role of protein sumoylation, it is not surprising that alternation of sumoylation will ultimately affect cell growth as well as cancer development. As an essential E2 conjugating enzyme for sumoylation, …
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The Mycobacterium tuberculosis KatG gene : identification of a novel function and analysis of the regulation of expression
… confer resistance to ethyl methane sulfonate on DNA repair-deficient Escherichia coli cells. The first aim of this study, therefore, was to examine the role played by the M tuberculosis katG gene in DNA repair. The strategy used was overexpression of different regions of the gene in DNA …
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Analysis of Meiotic Cancer Testis Antigens and Their Contribution to Tumorigenesis
… roles in cell survival, modulating response to DNA damaging agents, and DNA replication stress mitigation respectively. More specifically, we find HORMAD1 is critical for protecting stalled DNA replication forks in LUAD. Loss of HORMAD1 leads to nascent DNA degradation, an event which is …
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Regulation of neuronal genomic integrity through histone deacetylase cooperativity
… SIRT1 and HDAC1, in the neuronal response to DNA double strand breaks (DSBs). Both SIRT1 and HDAC1 were previously shown to promote neuronal survival in a mouse model of neurodegeneration in which the appearance of DSBs precedes other neurotoxic symptoms. Here I show for the first time the …
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Analysis of the sltA (stzA) gene and its orthologues in Aspergillus nidulansand other filamentous fungi
… factor regulating tolerance to cations, DNA-damaging agents and high arginine concentrations. The similar severe sensitivity of a sltA1 mutant (GO281) and stzA deletion mutants to these stresses indicated that the premature termination codon in sltA1 represents a total loss-of-function …
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