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Showing 1 to 20 of 51 for “"DNA Double-Strand Break"”.

  1. The Role of 53BP1 in DNA Double-Strand Break Repair

    Bothmer, Anne Helen

    <p>DNA double-strand breaks (DSBs) are dangerous insults to DNA integrity and can lead to genome instability if left unrepaired. However, the immune cell diversification reactions V(D)J recombination and Class Switch Recombination (CSR) require the formation of DSB intermediates, a process that is …

    rockefeller Repository record

  2. DNA double-strand break repair studied by atomic force microscopy

    Zabolotnaya, EkaterinaUniversity of Cambridge2018

    DNA double-strand breaks (DSBs), where both strands of the DNA duplex are simultaneously fractured, are considered the most lethal type of DNA damage. The conserved Mre11-Rad50 DNA repair complex enables the catalytic activities of the Mre11 nuclease and the Rad50 ATPase to function together to …

    cambridge Repository record

  3. Studies of site-specific DNA double strand break repair in plants

    Kuang, Xianyan2010

    … homology is provided by Agrobacterium-mediated T-DNA by floral dipping. The DSB inducer <i> Ac </i> is either first crossed into target lines or co-transformed with donor T-DNA, and several independent germinal recombinants have been recovered from both strategies with gene targeting frequency of …

    iastate Repository record

  4. Silencing, heterochromatin, and DNA double strand break repair in Saccharomyces cerevisiae

    Mills, Kevin D. (Kevin David), 1972-Massachusetts Institute of Technology1999

    Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.

    mit Repository record

  5. Mechanisms of DNA double strand break-mediated neurotoxicity in neurodegenerative disease

    Welch, Gwyneth M.Massachusetts Institute of Technology2022

    Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity and long lifespan. DNA double strand breaks (DSBs) are also linked to neurodegeneration and senescence. However, it is not clear how DSB-bearing neurons influence …

    mit Repository record

  6. ALKBH3 and FTO: New Epitranscriptomic Regulators of DNA Double-Strand Break Response

    Birta Dröfn Jónsdóttir 1996-2024

    … er hlutverk ALKBH3 og FTO í viðgerðum á tvíþátta DNA brotum skoðað. Tvíþátta DNA brot eru meðal alvarlegustu skemmda sem frumurnar okkar verða fyrir. Ef ekki er gert við þessar skemmdir, eða ranglega gert við, geta þær leitt til stökkbreytinga, litningayfirfærsla, og sjúkdóma t.d. krabbameins. …

    u-iceland Repository record

  7. Single-molecule studies reveal mechanisms of human DNA double-strand break repair

    Myler, Logan RossThe University of Texas at Austin2018

    DNA damage is ubiquitous to all organisms and very complex pathways have evolved to recognize and repair these lesions. The most deleterious DNA damages are double-strand breaks (DSBs), and a single unrepaired DSB can lead to cell death. In human cells, there exist two canonical pathways of DSB …

    texas Repository record

  8. Cell-Cell Junction Signaling Regulating DNA Double-Strand Break Repair In Breast Cells

    ETHIRAJ, SINDUJA2015

    … for epithelial cell malignancy in breast cancer. DNA double-strand break repair (DSBR) is one of the processes that get misregulated during breast cancer progression. In addition, radiation induced breaks such as those induced during radiation therapy to treat breast cancer patients are repaired …

    vcu Repository record

  9. Effect of Werner and Bloom Helicase Deficiencies On Dna Double-Strand Break Repair

    Smith, Krissy Lynn

    <p>DNA double strand breaks (DSBs) are very deleterious events that occur in cells. Causes can include endogenous agents such as reactive oxygen and nitrogen species, exogenous agents such as ionizing radiation and ultraviolet light, or other sources such as processing of spontaneous DNA lesions or …

    south-carolina Repository record

  10. Targeting DNA Double-Strand Break Repair to Potentiate Radio- and Chemo Therapy of Glioblastoma

    Gil del Alcazar, Carlos Rodrigo2017

    … was due to the augmented repair of TMZ-induced DNA double strand breaks (DSBs). TMZ induces DNA replication-associated DSBs that are repaired primarily by the homologous recombination (HR) pathway. We found that cell lines from recurrent cultures exhibited faster resolution of Rad51 foci and …

    utswmed Repository record

  11. DNA-PKcs/ Artemis Complex in DNA Double-Strand-Break Repair: Cryo-EM and Biochemical Studies

    Liang, ShikangUniversity of Cambridge2020

    DNA is the main carrier of inheritance and DNA damage will thus have serious consequences. DNA double-strand breaks (DSB) are amongst the most lethal forms of DNA damage. One DSB can lead to catastrophic consequences including cancer and cell death. To fix it, there are two main mechanisms-- …

    cambridge Repository record

  12. Identification and characterization of novel genes involved in DNA double strand break repair process in the yeast Saccharomyces cerevisiae

    Omidi, KatayounCarleton University2017

    DNA Double Strand Break (DSB) is the most severe form of DNA lesion. Unrepaired DSBs and/or mutations in key DSB repair genes can lead to genomic instability, cancer or even cell death. DSBs can be repaired by two independent pathways; Homologous Recombination (HR) and Non-Homologous End Joining …

    carleton Repository record

  13. Development of Novel Technologies to Investigate DNA Double-Strand Break Repair Uncovers a Role for the ATM Kinase in Error-Free NHEJ with Implications for Neurodegenerative Diseases

    Kruswick, Alex J.Massachusetts Institute of Technology2025

    DNA double strand breaks (DSBs) are considered to be the most lethal genotoxic lesion because they can result in chromosomal translocations or result in a major loss of genetic information if repaired incorrectly. To preserve genomic integrity, mammalian cells have evolved a set of complimentary …

    mit Repository record

  14. Structural and biophysical analysis of Human DNA repair protein CtIP

    Morton, Christopher RobertUniversity of Cambridge2019

    … by endogenous and exogenous sources of DNA damage. The successful repair of DNA lesions is necessary for cellular survival and prevention of disease such as cancer. Therefore, complex molecular pathways have evolved to allow for accurate and timely DNA repair. It is now well-established …

    cambridge Repository record

  15. A functional role of chromatin remodeling factor, Rsf-1 in the DNA damage signaling pathway

    조, 수진2014

    … been reported that SNF2h ATPase is recruited to DNA damage sites (DSBs) in poly(ADP-ribosyl) polymerase 1 (PARP1)-dependent manner in DNA damage response (DDR), the function of Rsf-1 is still elusive. Here we show that Rsf-1 is recruited to DSBs confirmed by various cellular analyses …

    ajou Repository record

  16. Identification of therapeutic targets and dependencies in ZNF703-amplified breast cancer

    Lui, AllanUniversity of Cambridge2024

    … lethal with loss of OTUD5, a regulator of DNA double strand break repair and interferon signalling. Furthermore, ZNF703 overexpression favours error-free repair of CRISPR-Cas9-induced double strand breaks and confers increased dependency on homologous recombination. Interactomic and …

    cambridge Repository record

  17. Crosstalk between DNA end resection and RNA metabolism

    Prados Carvajal, Rosario2020

    DNA suffers thousands of lesions from exogenous and endogenous sources. Nevertheless, double-strand breaks (DSBs) are the most dangerous form of DNA damage because if they are not properly repaired they can lead to mutations and genomic instability. In order to repair them, cells have developed two …

    sevilla Repository record

  18. EXAMINING THE ROLE OF THE XAB2 PROTEIN IN HOMOLOGOUS RECOMBINATION

    Neherin, Kashfia2015

    <p>DNA double strand break (DSB) repair is critical to maintain genomic integrity and cell viability. DSBs can occur during the course of cell cycle during replication or transcription, or by exogenous agents such as chemicals or ionizing radiation. For my thesis, I studied homologous recombination …

    csusb Repository record

  19. Genetic and epigenetic regulation of the cell wall glycoproteins, Flo10p and Flo11p, generate phenotypic variation in S. cerevisiae

    Halme, Adrian Jones, 1971-Massachusetts Institute of Technology2003

    … from genetic regulation, in which changes in DNA sequence produce the variant phenotype, or epigenetic regulation, in which there are no changes in DNA sequence associated with the variant phenotype. This doctoral thesis describes the identification and analysis of novel phenotypic variation …

    mit Repository record

  20. Evaluation of 64Cu-ATSM in cell culture for potential use as a radiotherapy agent

    McMillan, Dayton Datteri, author, Kato, Takamitsu, advisor, Callahan, Gerald, committee member, Kraft, Susan, committee memberColorado State University. Libraries2014

    … the biological mechanism for cell killing and DNA damage due to high LET electrons released in the decay of 64Cu is unknown. To evaluate how high LET Auger electrons play a role in cell death and DNA damage, Chinese hamster ovary (CHO) cell lines proficient and deficient in DNA nonhomologous …

    colostate Repository record

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