Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"DDR1"”.
-
The Role of the Discoidin Domain Receptor-1 (DDR1) in Vascular Smooth Muscle Cell (VSMC) Mechanosensing
… identifies how Discoidin Domain Receptor-1 (DDR1) mediates stiffness sensing and how this influences vascular smooth muscle cell (VSMC) calcification. In the first study, experiments in primary murine Ddr1+/+ or Ddr1-/- VSMCs revealed that DDR1 promotes VSMC calcification in a …
-
RUOLO DELL'ISOFORMA A DEL RECETTORE INSULINICO E DEL SUO PARTNER MOLECOLARE DDR1 NEL CANCRO AL SENO
… riprogrammazione metabolica del cancro mammario. DDR1, un recettore del collagene spesso disregolato nel cancro, è coinvolto in un crosstalk funzionale sia con l'IR-A che con il recettore del fattore di crescita simile all'insulina 1 (IGF1R). Obiettivo dello studio è stato indagare il ruolo di …
-
Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-Mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
… tyrosine kinase discoidin domain receptor 1 (DDR1), implicated in regulating cell proliferation, migration, adhesion, ECM remodeling, and response to growth factors. Additionally, collagen has been shown to promote chemoresistance in pancreatic tumor cells. I hypothesize that the regulation of …
-
Combined Inhibition of Ddr1 and Cdk4/6 Induces Synergistic Effects In Er-Positive, Her2-Negative Breast Cancer With Pik3Ca/Akt1 Mutations
<p><strong>COMBINED INHIBITION OF DDR1 AND CDK4/6 INDUCES SYNERGISTIC EFFECTS IN ER-POSITIVE, HER2-NEGATIVE BREAST CANCER WITH <em>PIK3CA/AKT1</em> MUTATIONS</strong></p> <p>Maryam Shariati, M.S. Advisory Professor: Funda Meric-Bernstam, M.D.</p> <p>Molecular alterations in the phosphatidylinositol …
-
Role of DARPP-32 in Breast Cancer Cell Signalling and Migration
… activation of the receptor tyrosine kinase DDR1, a collagen receptor implicated in cell adhesion and migration. This thesis describes the identification of DARPP-32 as a novel interactionpartner to DDR1. We demonstrate that DARPP-32 inhibits MCF-7 cell migration and that this effect requires …
-
Molecular determinants of mammary differentiation and breast cancer progression
… the collagen receptor tyrosine kinase, DDR1, as a regulator of mammary stem cell differentiation. Mechanistically, we coupled ex vivo functional assays with single cell transcriptomic sequencing to show that DDR1 is required for basal fate commitment to activate JAG1 expression, which …
-
Wnt-5a signaling in breast cancer metastasis
… cancer cell migration and to associate with DDR1, a tyrosine kinase receptor that participates in Wnt-5a signaling. These results further emphasize the importance of Wnt-5a in breast cancer metastasis, and they identify a novel potential treatment strategy.
-
Mechanical Deformation of the Extracellular Matrix Mediates Cellular Activation and Mechanotransduction
… collagen receptors: domain receptor 1 and 2 (DDR1, DDR2),and &beta 1 integrin, and the contractile protein, &alpha-smooth muscle actin (&alpha-SMA) . We report that mechanical loading induces RBL-2H3 degranulation via RGD integrins and regulates age-dependent differences in collagen I and III …
-
Hear Today, Gone Tomorrow: Exploring Quinoxaline Derivatives as a Treatment for Noise-Induced Hearing Loss
… The kinome assay predicted the upregulation of DDR1 and Tec kinases up to 21d post-noise exposure. This is a novel finding as these kinases have not been previously linked to NIHL pathogenesis. In all, Qx34 and Qx62 are the top derivatives from this study, and future studies are needed to assess …
-
New technologies and methodologies for the study of human mammary epithelial differentiation and development
… second study found that the collagen receptor, DDR1, is required for mammary stem cell differentiation into mature basal cell states, and that this process also drives luminal differentiation through interlineage Notch signaling. These studies provide a new set of tools to better understand …