Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"DAF-16"”.
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The significance of DAF-16 and its role in the phenotypic covariance of longevity, immunity and stress resistance in the Caenorhabditis nematodes
… activation of the forkhead transcription factor DAF-16 both extends lifespan and simultaneously increases immunity and stress resistance. It is known that lifespan varies significantly among the Caenorhabditis species but, although DAF-16 signalling is highly conserved, it is unclear whether this …
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Genetic analysis of novel regulators of neuronal migration in Caenorhabditis elegans: the insulin/IGF-1 signaling pathway, a chromatin-binding factor ZFP-1 (AF10) and endogenous RNAi
… pathway modulates the activity of the conserved DAF-16/FOXO transcription factor non-autonomously in the hypodermis to regulate HSN migration. Furthermore, I identify PAK-1, a p21-activated kinase, as a downstream target of DAF-16 in the hypodermis. This study is the first to demonstrate a …
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A Bacterial Metabolite Causes Changes in Neurodegeneration and Aging Via Bioactivation and Hormesis in Caenorhabditis Elegans
… of the stress activated transcription factor DAF-16. The expression pattern of such genes and the differences in longevity depended on functional DAF-16. Previously identified environmental sources of neurodegeneration and aging are known to target mitochondria. Further aging analysis revealed …
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Búsqueda de potenciales agentes quimioterápicos para los trastornos del espectro autista (TEA) utilizando Caenorhabditis elegans como modelo de estudio
… y moleculares asociados a la mutación del gen daf-18 (homólogo de PTEN en C. elegans) y evaluar las consecuencias funcionales de estas mutaciones. Adicionalmente, abordamos una estrategia farmacológica que busca revertir los fenotipos alterados, basándonos fundamentalmente en los CCs y las …
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Dietary Plant Lectins May be an ‘Unknown Etiology’ in Parkinson’s Disease and Dietary Bioactive Compounds Affect Lifespan and Fat Storage Aspects of Caenorhabditis Elegans
… by PJ treatment in wild type (N2, 56%) and daf-16 mutant (daf-16(mgDf50)I) (GR1307, 18%), by POMx in N2 (28%) and in GR1307 (10%), or by EA (11%). PJ reduced intestinal fat deposition (IFD) in N2 (-68%) or in GR1307 (-33%). The IFD was increased by POMx in N2 (137%) and in GR1307 (26%), by …
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Analyses of diverse stresses, including hypoxia, cyanide, and hypergravity in Caenorhabditis elegans
… between the stress response modulators HIF-1, DAF-16, and HLH29 in C. elegans. We found significant over-representation of DAF-16 target genes, as well as HLH29 target genes in our lists of genes up- or down- regulated by hypoxia or in animals with over-active HIF-1. Genes identified in this …
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Estudio de la regulación de la dinámica de localización subcelular de HLH-30: evidencia de un mecanismo dependiente de redox
… nuclear, a pesar de que se ha descrito que DAF-16 y HLH-30, ambos factores de transcripción que regulan la respuesta a estrés, se asocian para formar un complejo y cooperar en la activación de varias respuestas del organismo, demostramos que DAF-16 no es necesario para la translocación …
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The ecological genetics of senescence and stress resistance in Caenorhabditis elegans
… distributions of the FOXO transcriptions factor DAF-16, suggest that this is because age-1 mutants are more able to survive, develop and reproduce during and/or after exposure to environmental stress, due to increased expression of genes involved in somatic maintenance and repair. Using …
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Role of BEC-1/Beclin 1 and Autophagy Genes in <i>C.elegans</i> Germline Cell Proliferation
… acts independently of the GLP-1/Notch or DAF-7/TFG-β pathways, but interacts with components of DAF-2/IIR signaling pathway, to potentiate germline proliferation during development. Moreover, BEC-1/BECN1 requires DAF-18/PTEN but not DAF-16/FOXO for this function and can both promote and …
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Nutritional Control of L1 Arrest and Recovery in Caenorhabditis elegans by Insulin-like Peptides and Signaling
… We selected ten candidate agonists (daf-28, ins-3, ins-4, ins-5, ins-6, ins-7, ins-9, ins-26, ins-33 and ins-35) for further characterization in L1 stage larvae. We used destabilized reporter genes to determine spatial expression patterns. Expression of candidate agonists was largely …
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Identification of new genes and pathways that act to delay C. elegans aging
… pathway on a forkhead transcription factor DAF-16. We discovered that 14-3-3 proteins play a role in C. elegans lifespan determination. 14-3-3 proteins interact with the SIR-2.1 protein, and the 14-3-3 genes par-5 andftt-2 are required for the longevity mediated by sir-2. I1 overexpression, …
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Host-pathogen interactions in the innate immune response of the nematode Caenorhabditis elegans
… We suggest that ABL-1 controls two different DAF-16-dependent pathways to regulate this balance. Both pathways are necessary for wild type resistance to C. neoformans, whilst the activity of only one pathway is a requirement for the tolerance phenotype to S. Typhimurium. We infer from sequence …
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Stress-induced remodeling of the caenorhabditis elegans dauer
… remodel, including the FOXO transcription factor/DAF-16, phosphatase PTEN/DAF-18 and Cytochrome P450/DAF-9. Finally, we find that the TOR associated protein, RAPTOR/DAF-15 regulates mutually exclusive branching of the IL2 and FLP dendrites. Together, our results shed light on molecular processes …
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The nidogen-domain protein DEX-1 is necessary for the Caenorhabditis elegans dauer morphology and behavior
… during dauer is also regulated through DAF-16/FOXO-mediated transcriptional activation. Finally, we show that dex-1 genetically interacts with a family of zona pellucida-domain genes to regulate seam cell remodeling and alae formation. Taken together, this work shows that DEX-1 is an …
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DNA Damage-dependent Regulation and Function of akt-1 in Caenorhabditis elegans
… the Insulin-like receptor tyrosine kinase (RTK) DAF-2, the class I PI3K AGE-1 and the 3-phosphoinositide-dependent protein kinase 1 (PDK1) homologue PDK-1. This pathway ultimately controls the action of Akt homologues on the forkhead transcription factor DAF-16. The C. elegans Akt orthologue …
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Identifying the Role of DAP-1 and H3.3 Histones in Starvation and Longevity in <i>Caenorhabditis Elegans</i>
… <i>C. elegans</i> when worms were starved for 2-16 hours - a time period of starvation which can increase the mean lifespan of worms by up to 20%.<br/><br/>The aim of my thesis was to follow up on some of the proteins found upregulated upon starvation and to investigate if they have a role in …
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Modulation of touch sensitivity in Caenorhabditis elegans
… and integrin signaling converge on AKT-1 and DAF-16, which modulate touch sensitivity by regulating the transcription of mfb-1, an E3 ubiquitin ligase expressed in the TRNs. MFB-1 regulates the amount of MEC-4 channel on the plasma membrane, thus modulating touch sensitivity. Together, these …
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Combining microbial functional metagenomics and Caenorhabditis elegans genetics to uncover and characterise novel bioactive compounds
Marine bacteria produce a wide array of biologically active metabolites involved in defence strategies and pathogenesis against a range of metazoans target organisms. In return bacteriovorous metazoans, including nematodes, have developed sophisticated strategies to neutralise or avoid such …