Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 38 for “"Cytotoxicity assay"”.
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In vitro screening of Trametes versicolor and Acacia nilotica derivatives for antimalarial efficacy
… and 200 μg/ml, for each extracted compound. MTT assays were performed alongside parasite IC50 studies in order to define the toxicity profiles. 48 hours cycle IC50 values for T. versicolor and A. nilotica ethanol extractions were 45.54 ± 1.12 μg/ml and 45.54 ± 1.12 μg/ml while the 72-hour cycle …
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SYNTHESIS AND BIOLOGICAL EVALUATION OF SECOND GENERATION ANIBAMINE ANALOGUES AS NOVEL ANTI-PROSTATE CANCER AGENTS
… by altering the original synthetic route. While cytotoxicity assay proved the compounds to be non toxic to normal cells, anti-proliferation assay displayed that having a bulky, hydrophobic group in the side chain of the parent compound is essential for the activity. Looking at this data, the …
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The effects of a 1.8 GHz continuous electromagnetic fields on mucociliary transport of human nasal mucosa
… CBF when compared to the control group. In the cytotoxicity assay, the difference in survival rates was not found between the two groups. In the EMF-exposed group, protein kinase C (PKC) activity was increased during a PKC activity assay. The broad PKC inhibitor, Calphostin C abolished the …
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Investigations of the health benefits of buttermilk fat globule membrane lipid components
… cells as determined by the acid phosphatase cytotoxicity assay. Antiproliferative activity was lost after spray drying of buttermilk but was retained after heat treatment and freeze and spin drying. In contrast to natural buttermilks, fermented buttermilks inhibited growth to a lesser extent. …
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Design, Synthesis and Biological Evaluation of Novel Estradiol-Triazole Analogs Targeting Epidermal Growth Factor Receptors in Colorectal Cancer
… and biologically evaluated. Antiproliferation/cytotoxicity assay conducted on CRC cancer cell line (HT-29) showed that 5 out 14 analogs demonstrated potential antiproliferation activities ranging from 3.5 μM to 30 μM in comparison to a chemotherapeutic agent 5- flurouracil (5-FU) (IC50 17.3 μM) …
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Study of the antioxidant, anti-inflammatory and anti-diabetic effects of extracts from Cotinus coggygria in models with experimental animals and cell cultures // Проучване на антиоксидантното,противовъзпалително и противодиабетно действие на екстракти от Cotinus coggygria в експериментални модели с опитни животни и клетъчни култури
… of the extracts of C. coggygria; (4) MTT cytotoxicity assay of extracts of C. coggygria on cell cultures: 3T3-L1 (murine preadipocytes) and J774A.1 (murine macrophages);5)treatment of male Wistar rats with three aqueous extract from the leaves and aqueous-ethanolic extract of wood in a …
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A study on the medicinal potential of Artemisia afra, a traditionally used herb in Namibia
… was also determined. The albumin denaturation assay was used for determining the in vitro anti-inflammatory response of the extracts of ‘Wilde als’ using egg albumin derived from a fresh hen’s egg as the protein source. The DPPH antioxidant assay was used to determine the radical scavenging …
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A License to Kill: Understanding Natural Killer Cell Licensing to Fight Cancer
… (KIRs) and activation by the NKp46 natural cytotoxicity receptor, including several related to cellular metabolic pathways. We explored cellular metabolism in the two subsets and found that licensed NK cells are highly glycolytic, and use glycolysis and mitochondrial respiration for …
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Microemulsions containing centella asiatica extract as antioxidant and anti-acetylcholinesterase agent
… for antioxidant activity by DPPH, ABTS, and FRAP assays, anti-acetylcholinesterase activity, in-vitro drug release, and cytotoxicity assay. Four ternary phase diagrams were successfully constructed and based on each ternary diagram, four transparent MEs were selected. The results of this study …
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The cytotoxic effect of higher plant extracts on recurrent ovarian cancer cells
… be used as a possible treatment. Methods: A cytotoxicity assay using twenty-nine higher plant extracts was carried out against two ovarian cancer cell lines (A2780 and A2780cis). The most toxic plant extracts where then used in a dose-response assay to show the potency of the natural products …
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Synthesis, Characterisation and Biological Activity of Silicon Nanoparticles Functionalised by Anticancer Compounds
… emission and elemental analysis. In vitro cytotoxicity assay was employed to evaluate the effect of SiNPs. Confocal microscopy images demonstrate SiNP internalisation and flow cytometry data confirms receptor-mediated targeting in cancer cells. Isothiocyanates (ITCs) can prevent the onset …
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Pesticide Mixtures Induce Immunotoxicity: Potentiation of Apoptosis and Oxidative Stress
… butoxide (PBO; a synergist). Based on minimum cytotoxicity (> LC25), the following concentrations were chosen for the pesticide mixture studies: 70μM lindane (Lind), 50μM malathion (Mal) and 55μM PBO. In the AlamarBlue cytotoxicity assay, individual pesticide and mixtures of malathion/PBO …
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Structural and Synthetic Studies of Bioactive Natural Products
… All these compounds were weakly active in a cytotoxicity assay. Two new isoflavones were isolated from the roots of an Egyptian lotus plant, Lotus polyphyllos. Both compounds were characterized by UV, NMR, and mass spectroscopic analysis The methanol extract from the leaves and bark of a …
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Phytochemical Investigation and Bioactivity Assessment of Medicinal Plant from Northern Nigeria
… and 2032 μM, respectively. A growth Inhibition assay showed the activity of gallic acid as bacteriostatic, and pyrogallol as bacteriocidal against tested microorganisms. Interestingly, the bacteriocidal compound was found to arise by conversion of gallic acid by the endophyte Enterobacter …
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Identification, characterisation and design of bioactive peptides from Chinese frogs
… D-amino acid residues. Through antimicrobial assay, cytotoxicity assay and in vitro and in vivo stability assays, it was found that DMPC-1OB had strong and broad-spectrum antimicrobial activity, low cytotoxicity and high stability in vitro and in vivo. In the last chapter, a 22-mer amidated …
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A three-dimensional agent-based model of glioblastoma with applications towards in vitro and in vivo therapy simulation
… results from a three-dimensional in vitro cytotoxicity assay that measures CAR T cell efficacy against glioblastoma. We adjusted T cell parameters to capture patterns of CAR T cell trafficking, proliferation, and persistence observed in this experimental system. The proliferation rate and …
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Characterizing the role of Nucleosome Remodeling Factor (NURF) in tumorigenesis and metastatic progression using mouse models of breast cancer.
… performed an in vitro natural killer (NK) cell cytotoxicity assay against 66cl4 tumors and found greater susceptibility to NK killing in Bptf knockdown tumors.
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Anti-platelet aggregation activity of melaleuca bracteata var.revolution gold derived betulinic acid and its derivatives
… anticoagulant, anti-oxidant and cytotoxicity activity. The compound structures were confirmed through spectral nuclear magnetic resonance (NMR), mass (MS) and infrared (IR) spectroscopy data analysis. The antiplatelet aggregation activities of the compounds were evaluated against …
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The synthesis, characterisation and bioapplications of Novel Gold-Zinc Telluride Core-shell Nanoparticles
… to both parental materials. The biosafety and cytotoxicity of these nanoparticles was established using normal human colon, mammary epithelial and cancer cells of breast, prostate and colon origin. Moreover, under certain conditions the particles expressed cytokines in low concentrations and …
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Design, Synthesis and Development of Transporter Targeting Agents For Image-Guided Therapy and Drug Delivery
… a slow-release pattern in <em>in vitro</em> cytotoxicity assay and exhibited anti-cancer efficacy with reduced toxicity in <em>in vivo</em> tumor growth delay study.<strong> </strong>In conclusion, both N4amG and GP are transporter-based targeting agents. Radiolabeled N4amG can be used for …
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