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Showing 1 to 20 of 39 for “"Cyclooxygenase (COX)"”.
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The relationship between nitric oxide synthase (NOS) and cyclooxygenase (COX) in the control of cervical ripening and parturition
… if there is relationship between iNOS and COX-2 in the control of cervical ripening and parturition. Cervices were obtained from estrus and timed pregnant Sprague-Dawley rats (n = 4-10 per group) under normal conditions; or after treating with LPS (100ƒÝg i.p.), Onapristone (3mg/rat), …
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Structural and thermal characterisation of NSAIDs and cyclodextrin-NSAID complexes
… acid, known as arachidonic acid, by the enzyme cyclooxygenase (COX) in the presence of oxygen. NSAIDs act on this biochemical pathway by inhibiting the COX enzyme, thereby exerting their analgesic effect. Since, however, the solubility and bioavailability of NSAIDs are generally poor, …
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Gender differences in aortic endothelial function in a rat model of streptozotocin-induced diabetes : possible role of superoxide and cyclooxygenase
… rats, and the potential role of superoxide and cyclooxygenase (COX) metabolites in diabetes-induced vascular dysfunction.</p>
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Durch den Keratin 6-Promotor gesteuerte Expression von Cyclooxygenase-2 in transgenen Mauslinien: Cyclooxygenase-2 bedingte Veränderungen in der Epidermis und anderen stratifizierten Epithelien
… zwischen der Prostaglandin H-Synthase Cyclooxygenase (COX)-2 und Tumorentwicklung. Mit dem Ziel, die Rolle der COX-2 in der epidermalen Tumorentwicklung zu untersuchen, wurden in dieser Arbeit transgene Mäuse etabliert, in denen eine konstitutive Expression der COX-2-cDNA unter der …
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Effects of ibuprofen on Rainbow Trout (Oncorhynchus mykiss) following acute and chronic waterborne exposures
… on rainbow trout (Oncorhynchus mykiss). Cyclooxygenase (COX) activity, vitellogenin (VTG) concentration and ethoxyresorufin-O-deethylase (EROD) activity were evaluated following waterborne ibuprofen exposure of trout to 1 and 10 mg/L in the acute exposure and 1, 32 and 1000 μg/L in the …
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Synergistic inhibition of cyclooxygenases and monoacylglycerol lipase in neuropathic pain
… drugs (NSAIDs). NSAIDs inhibit one or more cyclooxygenase (COX) enzymes and are effective, commonly used analgesics that have relatively fewer side effects than other treatments. However, chronic cyclooxygenase inhibition also causes gastrointestinal inflammation and increased risk of …
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Influence of the reducing agent triphenylphosphine on cyclooxygenase-1 metabolism of arachidonic acid
<p>Cyclooxygenase (COX) metabolizes the polyunsaturated fatty acid arachidonic acid (AA) to PGG2, a cyclic endoperoxide that also contains a hydroperoxide, which is subsequently reduced to an alcohol in the enzyme to yield PGH2. Reactions catalyzed by COX-1 are significantly influenced by lipid …
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Computational Approaches For Designing Protein/inhibitor Complexes And Membrane Protein Variants
… microtubule-stabilizing agents and inhibitors of cyclooxygenase(COX)-I and 5-lipoxygenase (5-LOX). In Part II (Chapters III and IV), I focus on membrane proteins, which are notoriously difficult to work with due to their low natural abundances, low yields for heterologous over expression, and …
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Einfluss von Celecoxib auf die Entstehung und den Verlauf einer kardialen Hypertrophie
… bereits gezeigt werden, dass der selektive Cyclooxygenase (COX)-2 Hemmer Celecoxib den Akt-Signalweg beeinflussen kann. Wir untersuchten den Effekt von Celecoxib auf den Akt-Signalweg in Kardiomyozyten und die hypertrophe Antwort. In isolierten Kardiomyozyten hemmte Celecoxib …
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Effekte der Stimmungsstabilisatoren Lithium, Valproat und Lamotrigin auf die Cyclooxygenase-2-Synthese in SK-N-SH Neuroblastomzellen
… und Valproat (VPA) im Rattenhirn sowohl die Cyclooxygenase (COX)-2-Synthese als auch die Prostaglandin E2 (PGE2)-Ausschüttung reduzieren. Aufbauend auf dieser Beobachtung sollten in dieser Arbeit die Effekte der Stimmungsstabilisatoren Lithium, Lamotrigin und Valproat auf die …
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Towards Fluorinated Substrate Analogs and N-Acylated 2-Aminopyrimidine Inhibitors of Lipoxygenases
Cyclooxygenase (COX) and lipoxygenase (LOX) catalyze the rate-determining step in the production of arachidonic acid- derived signaling molecules (eicosanoids) within the body. COX has been extensively investigated, which has enabled the design of non-steroidal inflammatory drugs (NSAIDs) such as …
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Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow with Exposure to Intermittent Hypoxia in Humans
… BP involves multiple mechanisms but the role of cyclooxygenase (COX) catalyzed vasoactive prostaglandins (PG) is unclear. Methods: A placebo controlled double-blind randomized cross-over trial was designed using nonselective COX inhibitor indomethacin (50 mg tid/po), selectively COX-2 inhibitor …
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Effects of chronic exposure to ibuprofen and naproxen on Florida flagfish (Jordanella floridae) over one complete life-cycle
… NSAIDs function through the inhibition of cyclooxygenase (COX), an enzyme present in two isoforms in the body; the constitutively expressed COX-1 and the inducible COX-2. Traditional NSAIDs like ibuprofen inhibit both isoforms with little selectivity while newer variants such as naproxen …
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Investigating Prostaglandin E2 activation of the p38 pathway of oesophageal squamous cell carcinoma
… by a positive feedback theory involving cyclooxygenase (COX)-2. Conclusions: Even though PGE2 was shown not to be sufficient to promote Het1a proliferation, regulation of Cyclin D1 and IL-6 transcription via p38 was observed. Furthermore, the expression profile might support the …
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Spontaneous tone in deoxycorticosterone acetate-salt hypertensive rats
… while H202 serves as a protective mechanism. The cyclooxygenase (COX) inhibitor, valeroyl salicylate, and the thromboxane-prostaglandin (TP) receptor antagonist, SQ 29548, inhibited spontaneous tone. 20-hydroxyeicosatetraenoic acid (20-HETE) production was increased in rings from DOCA-salt …
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Characterization of the prostacyclinIP receptor system in the rat kidney: Implications for diabetic nephropathy
… a MAPK activator. PGI2 synthesis is dependent on cyclooxygenase (COX) and PGI 2 synthase (PGIS). We show increased COX-1 and -2 in the medulla of STZ rats, as well as HG-IMCD. Only COX-2 was elevated in HG-MG. While PGE 2 synthase was augmented in the OM of STZ rats, PGIS protein was reduced in …
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The Involvement of the Cyclooxygenase Enzymes in the Gallus Domesticus Model of Ovarian Cancer
… of the work presented was to determine if the cyclooxygenase (COX) enzymes are involved in ovarian carcinogenesis in the hen as a model for the human disease. The expression patterns of COX-1 and -2 mRNA and protein in normal hen ovaries and hen ovarian tumors were determined. COX-1 mRNA …
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Inhibition and inactivation of prostaglandin synthase-2 and horseradish peroxidase
… pharmaceutical interest, containing both cyclooxygenase (COX) and peroxidase (POX) active sites. Development of PGHS-2-selective POX inhibitors may reduce the toxic and carcinogenic effects of PGHS-2 xenobiotic activation, as well as further define the role of this activity in vivo . …
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Correlation of Cyclooxygenase-2 and Microvessel Density with Prognosis in Transitional Cell Carcinoma of the Upper Urinary Tract
PURPOSE: Cyclooxygenase (COX)-2 plays an important role in cancer progression by affecting tumor cell proliferation, resistance to apoptosis, angiogenesis, and tumor invasion in several types of cancers. However, studies about COX-2 expression in transitional cell carcinoma of the upper urinary …
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Roles of proteasome, arachidonic acid, and oxytocin in bovine myoblast proliferation and differentiation
… (P < 0.05). Treating myoblasts with AA and the cyclooxygenase (COX)-1 and COX-2 inhibitor indomethacin or the COX-2-specific inhibitor NS-398 reversed the stimulatory effect of AA on myoblast proliferation (P < 0.05). The objective of the third study was to determine the role of the proteasome …
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