Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"Cutaneous melanoma"”.
-
The identification of diagnostic serological autoantibodies for Cutaneous Melanoma
Abstract not available.
-
An investigation into the Humoral Response in Cutaneous Melanoma
Melanoma is a cancer which develops from the malignant proliferation of melanocyte cells. There are 4 subtypes, of which cutaneous melanoma (CM), is the most prevalent (Rabbie et al., 2019). The T cell immune response in melanoma has been well defined, however, the B cell response is much less …
-
The molecular landscape of cutaneous melanoma and its clinical implications
Cutaneous melanoma arises due to the uncontrolled proliferation of melanocytes. It is the deadliest form of skin cancer and its incidence, particularly in younger adults, is rapidly rising worldwide. Over the past decade, multiple large-scale sequencing studies have uncovered the molecular …
-
The detection of occult metastatic disease in patients with cutaneous melanoma
The ability to identify melanoma patients with progressive disease is central to efficient management. The challenge therefore, is to develop prognostic markers and techniques which will allow the identification of those patients whom, at the time of primary tumor diagnosis, already have …
-
POTENTIAL OF TERAHERTZ PULSED REFLECTOMETRY AND IMAGING FOR THE EARLY DIAGNOSIS OF CUTANEOUS MELANOMA
In the last two decades the incidence rate of cutaneous malignant melanoma have been risen faster than any other form of cancer worldwide in the white-Caucasian population. The mortality rates over time show that an early diagnosis is the key point for quick treatment, which increase survival …
-
Identificazione e Validazione di Hotspot di Metilazione del DNA come Biomarcatori per il Melanoma Cutaneo
Cutaneous melanoma represents the most aggressive skin cancer due to its high invasive and metastatic behavior. Despite the adoption of novel screening programs and the development of new pharmacological treatments, the incidence and mortality rates of cutaneous melanoma are constantly increasing …
-
Clinico-morphological Characteristics, Histological Typification and Their Correlation with Some Molecular Markers in Cutaneous Melanoma // Клинико-морфологични характеристики, хистотипизация и корелацията им с някои молекулярни маркери при кожен меланом
Меланомът е злокачествен тумор с меланоцитен произход и изключително неблагоприятна прогноза. В областта на морфологичната диагностика на меланома навлиза практиката да се прилагат маркери, които по правило биват използвани за тумори с различна от тази на меланома хистогенеза. Те най-често се …
-
Investigation of key non-coding and coding genes in cutaneous melanomagenesis
Cutaneous melanoma is associated with significant morbidity and mortality representing the most significant cutaneous malignancy. As it is known that early diagnosis and treatment are the most efficient approaches to cure cutaneous melanoma, an improved understanding of the molecular pathogenesis …
-
Development of an oral DNA anti-cancer vaccine targeting an angiogenic peptide, proadrenomedullin N-terminal 20 peptide (PAMP)
… five times at 2-week intervals. Then, B16-F10 melanoma cells were injected either into the tail vein to generate lung metastases or subcutaneously to generate cutaneous melanoma. Furthermore, naive CD4+ T cells were exposed to PAMP, and their secretome was analyzed by proximity extension …
-
A Contemporary Appraisal of Ocular Melanoma in New Zealand (Aotearoa)
… represents a contemporary appraisal of ocular melanoma in New Zealand (Aotearoa), providing fundamental knowledge on uveal and conjunctival melanoma in a population with an exceptionally high burden of cutaneous melanoma. Seven nationwide studies, both prospective and retrospective, spanning 21 …
-
A GNAQ/11-driven zebrafish cancer model identifies MITF and YAP as key determinants for uveal melanoma
Uveal melanoma (UM) is a cancer of eye melanocytes that has a particularly poor prognosis and a dearth of treatment options. In contrast to cutaneous melanoma (CM), which is driven by oncogenic mutation of BRAF or NRAS, UM is driven by oncogenic mutations in GNAQ or GNA11 (>80% of patients). We …
-
New perspectives on melanoma: The role of PAX3
Background: Cutaneous melanoma is an aggressive form of skin cancer, arising in cutaneous melanocytes. The transcription factor PAX3 is critical for the proper development of neural crest lineages including melanocytes. Melanocytic cells show continued PAX3 expression from melanoblast formation in …
-
Genetic markers in circulating tumour cells as a measure of the metastatic propensity of uveal melanoma
Background: Uveal melanoma (UM) is an extremely aggressive disease with approximately 50% of patients developing incurable metastatic disease. Therefore, accurate prognosis of a patient is necessary for closer follow up and the earlier implementation of systemic adjuvant therapies in those most …
-
Effects of nNOS Inhibitors on Melanoma-Induced Immunosuppression
<p>The incidence of cutaneous melanoma (CM) rises despite advances in immunotherapy and targeted therapy. Studies have shown that interferon-gamma (IFN-γ), a pro-tumorigenic cytokine in CM, induces the expression of programmed death-ligand 1 (PD-L1), leading to the escape of melanoma cells from …
-
Is melanoma associated leucoderma (MAL) a distinct entity compared to classial vitiligo?
… have no higher prevalence for sun induced non-melanoma skin cancer and increased photo-damage. Protection and DNA-repair have been attributed to a functioning up-regulated wild type p53 / p21 cascade in association with up-regulated p76 MDM2. As some patients with cutaneous melanoma develop …
-
Establishment of MITF and TAZ as major determinants of uveal melanoma
Uveal melanoma (UM) is a cancer that arises from transformed melanocytes that exist in the uvea of the eye. Although UM is relatively rare, it is extremely deadly, due to the lack of treatment options for the metastatic disease. In contrast, cutaneous melanoma (CM), which is derived from …
-
Overcoming radioresistance by targeting p21 in cancer
… as an oncogene in colorectal cancer, uveal and cutaneous melanoma. Using HCT116 colorectal cancer cells and their counterpart knock-out for p21 – generated with CRISPR/Cas9 ribonucleofection approach – we demonstrated that p21 confers resistance to apoptosis promoting instead cell growth and …
-
Targeting Neuronal Nitric Oxide Synthase (nNOS) for Melanoma Treatment
<p>Human cutaneous melanoma is the most aggressive form of skin cancer and the incidence rates have continued to increase over the years. Neuronal nitric oxide synthase (nNOS) produces nitric oxide (NO) has been found to be overexpressed in human melanoma and the expression of nNOS is induced by …
-
Fattori prognostici nel melanoma cutaneo e nel tumore mammario associati a caratteristiche molecolari simil-staminali
… vimentin and GR expression in tumour tissue (melanoma), and their association with clinicopathological variables, to evaluate any effect on tumour progression. There is no reported study addressing nestin expression in T4 breast cancer patients. Thus, the aim of the present study was also to …
Page 1 of 2