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Showing 1 to 20 of 27 for “"Clostridioides difficile"”.
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Mechanistic Insights Into Vancomycin Resistance In Clostridioides Difficile
<p><em>C. difficile </em>is a nosocomial, opportunistic pathogen that has become more hypervirulent over the last decade. Vancomycin is currently a frontline antibiotic for the treatment of <em>C. difficile</em> infections. Yet, strains of <em>C. difficile</em> are becoming non-susceptible to …
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The Lived Experience of Patients with Clostridioides difficile
<p><strong>Background: </strong><em>Clostridioides difficile (C. difficile) </em>is the most common healthcare-acquired gastrointestinal infection in the United States. While there is a plethora of information on the treatment and diagnosis of <em>C. difficile</em> infection (CDI) in the …
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Investigating novel treatment approaches to combat Clostridioides difficile
… novel treatment approaches to combat Clostridioides difficile Rusha Pal ABSTRACT Clostridioides difficile is the leading cause of antibiotic-induced diarrhea and colitis in hospitals and communities worldwide. The enteric pathogen, classified to be an "urgent threat" by the United …
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Investigating the enzyme activity of a <i>Clostridioides difficile</i> amidase complex
<i>Clostridioides difficile</i> is a highly antibiotic resistant and infectious endospore-forming bacterium, responsible for an estimated 450,000 cases per year. The formation of an endospore is necessary for the survival of the bacterium while in-transit between hosts and while passing through the …
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Toxina b y binaria como valor pronóstico en la infección por clostridioides difficile
… Introducción El diagnóstico de la infección por Clostridioides difficile (ICD) ha experimentado un notable incremento en la última década. Uno de los motivos principales de este aumento es el elevado consumo de antibióticos y el aumento de comorbilidad de los pacientes; otro motivo sería la mayor …
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Towards Phage Therapy: Characterization of Clostridioides difficile Bacteriophages from a South African Strain Collection
Clostridioides difficile infection is a worldwide public health concern that affects persons with gastrointestinal dysbiosis, notably hospitalised patients on antibiotic therapy and those with other types of gastrointestinal conditions. This opportunistic infection is caused by a Grampositive, …
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Investigating the Roles of CwlD and GerS in <i>Clostridioides difficile</i> Spore Cortex Modification
Clostridioides difficile is a notable nosocomial pathogen distinguished by its capacity to produce spores, essential for its survival and dissemination. The spore cortex, consisting of a modified peptidoglycan layer, is essential for dormancy and germination. This work examines the enzyme CwlD, …
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Ecological studies of Clostridioides difficile and COVID-19 infection with the application of space-time risk models
… to infections, specifically Clostridiodies difficile infection (CDI) and COVID-19, to identify risk factors at an ecological population-based level. A mixture of open-sourced and routinely collected data, at different spatial scales, were used to understand the surveillance capacities of …
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Determinación del microbioma intestinal en pacientes con infección por clostridioides difficile adquirida en unidad de cuidados intensivos y comunidad
Clostridioides difficile (CD), es considerada como la principal causa de diarrea asociada al uso de antibióticos, la cual se asocia a una desregulación de la microbiota intestinal del hospedero, que afecta a los diferentes componentes de la microbiota, siendo el bacteriano el más ampliamente …
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Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa
… to determine the prevalence of MDROs and C. difficile and risk factors for carriage amongst residents of RCFs in Cape Town, South Africa. Methods We performed a cross-sectional surveillance study at three RCFs. Chromogenic agar was used to screen skin swabs for methicillin-resistant …
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Functionalization of phage endolysins to treat infections of spore-forming Clostridia bacteria in the era of antibiotic resistance
… toxins and exhibit antibiotic resistance. *Clostridioides difficile* is a nosocomial pathogen responsible for thousands of deaths every year, whereas *Clostridium perfringens* is a common cause of food poisoning and a notable veterinary pathogen. Research on *Clostridia* spores and phage …
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Learning the magnitude and duration of influence of infections
Clostridioides difficile infections (CDIs) impose a substantial burden on the healthcare system leading to poor health out comes, mortality and costs to the heath-care system estimated at greater than $5 billion. One of the reasons why CDIs are hard to control is the contribution of individual …
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NeuralPALS - learning exposure functions and infection probabilities for contagion spread
… preliminary results in determining the spread of Clostridioides difficile.
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Systems approaches to infer microbial community interactions and their impacts on ecosystem function
… models (MCMMs) can be leveraged to predict Clostridioides difficile (C. difficile) colonization in the human gut microbiome, provide mechanistic insights into the niche of C. difficile across different community contexts, and assess probiotic interventions designed to inhibit C. difficile …
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Repurposing Antibacterial Compounds and Natural Products to Combat Vancomycin-Resistant Enterococci
… and ridinilazole, originally designed to target Clostridioides difficile, for their activity against VRE. Both compounds showed exceptionally low minimum inhibitory concentrations and were bacteriostatic against VRE in vitro. In a Caenorhabditis elegans infection model, treatment with either …
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Structural and Biochemical Characterization of Glycyl Radical Enzymes Abundant in Mammalian Gut Microbiota
… the pathogen and disease-associated bacteria, Clostridioides difficile and Bilophila wadsworthia, respectively. Overall, our work on HypD and IslA enabled us to propose enzymatic mechanisms for these new GREs; we can now take structure-based approaches to designing enzyme inhibitors that could …
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Computationally and Experimentally Exploring the Type IV Pilus Assembly ATPase for Antivirulence Drug Discovery
… the experimental attempt to express and purify Clostridioides difficile PilB as an active ATPase. Two of the seven C. difficile PilB variant proteins expressed led to soluble protein while one construct remains to be explored. The results of these studies provide insight for future methodology …
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Sex as a Biological Variable in Preclinical Animal Studies with an Infectious Disease Exemplar.
… important in infectious diseases such as Clostridioides difficile infection, where sex has been identified as an independent risk factor for disease development. Emerging evidence has suggested that sex- and hormones play a protective role against disease susceptibility. Despite evidence …
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Investigation of Narrow Spectrum Targets in Antibacterial Drug Discovery
… infections caused by streptococcal species and Clostridioides difficile, are presented herein. Bacterial topoisomerase I represents a potentially promising narrow-spectrum target as studies have arisen demonstrating its essentiality in bacterial species lacking the only other type IA …
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Gnotobiotic Pig Models for the Study of Enteric Pathogen Replication and Pathogenesis
Clostridioides difficile (C. difficile) and human rotavirus (HRV) are leading causes of bacterial and viral gastroenteritis worldwide. Treatment and vaccination options for both pathogens have significant limitations. C. difficile infections are treated with antibiotics, which is paradoxical as C. …
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