Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 164 for “"Clinical Translation"”.
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Clinical Translation of Optoacoustic Imaging in Breast Cancer
… imaging investigation/technique currently in clinical feasibility studies for breast cancer diagnosis and staging. The technique applies pulsed light to the tissue of interest where molecules absorb the light photons and generate acoustic pressure waves. The resulting acoustic responses are …
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Clinical Translation of Dynamic OCE for Corneal Biomechanical Assessment
… challenge. This dissertation aims to clinically translate dynamic optical coherence elastography (OCE) for spatially-resolved quantification of human corneal biomechanics in vivo. Methods: An air-pulse–based OCE system was adapted for noninvasive clinical assessment of corneal elastic …
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Technical Development of Hyperpolarized [1-13C]Pyruvate Imaging for Clinical Translation
… Over the past few years since the first clinical study with prostate cancer patients, translational studies using this imaging technique have been focused on demonstrating the feasibility of applying to healthy subjects and patients under several pathophysiological conditions. However, …
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Biofabrication technologies enabling vascularization of organ- scale engineered tissues for clinical translation
… medicine closer to the realization of clinically viable, organ-scale engineered tissues.
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Mathematical approaches for the clinical translation of hyperpolarised 13C imaging in oncology
… dynamic nuclear polarisation is an emerging clinical technique which enables the metabolism of hyperpolarised 13C-labelled molecules to be dynamically and non- invasively imaged in tissue. The first molecule to gain clinical approval is [1-13C]pyruvate, the conversion of which to …
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Facilitating the Clinical Translation of Flash Radiotherapy Through Dosimetry Development and Beam Parameter Optimization
… dose rate RT in a variety of <em>in vivo</em> preclinical models<sup>2</sup>. This phenomenon has been termed the “FLASH effect.” FLASH RT represents a fundamentally new paradigm for increasing the therapeutic index of RT relative to the same doses given at CONV dose rates (0.01–0.1 Gy/s), …
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DEVELOPMENT OF A NANOPARTICLE-BASED PLATFORM FOR THE DELIVERY OF THERANOSTIC AGENTS TO TUMOR TISSUE: TOWARD CLINICAL TRANSLATION
… remains a major challenge in oncology, as many clinically effective drugs are limited by poor tumor specificity and dose-limiting systemic toxicity. Previous studies from the laboratory have explored the use of tumor-derived and patient-derived EVs as efficient, natural, and biocompatible …
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Clinical translation of nanomaterials for early detection of genetic abnormalities in fetus and retinopathy in neonates and adults
Nuclear medicine covers a wide variety of radionuclides to meet demands of disease. In the current study, first we have looked at the application of mono-amine mono-amide ligands for Re(V), 99mTc(V), and 186Re(V) with respect to bombesin for receptor targeting in the pancreas. While procedures for …
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Optical spectroscopy for biological and biomedical applications: potentially impacting future of healthcare with research, clinical translation and education
Clinical interventions have been significantly improved by recent advances in devices for disease detection, monitoring, diagnosis and surgical guidance. However, most of the current imaging technologies provide primarily morphological/structural information on analyzed subjects or samples, which …
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Phantom and computational studies towards the clinical translation of gas in scattering media absorption spectroscopy into neonatal respiratory care
… intestines and hip bone, one the most promising clinical applications could be the lung function assessment in neonates. The focus of this thesis is to investigate the potential of translating GASMAS into such an application, combining a computational and experimental approach. Most of the work …
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From Sample to Answer: Innovations in sample processing and CRISPR-based diagnostics for enhanced clinical translation and field deployment
… the use of SHINE beyond SARS-CoV-2 to other clinically relevant pathogens. We developed and validated SHINE assays to detect and discriminate species, subtypes, and variants of influenza virus, with important implications for public health and clinical care. We also designed and tested …
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Small molecule channels increase anion secretion and host defenses in cystic fibrosis airway epithelia: mechanistic studies and initial clinical translation
… that characterize CF lung disease. Major clinical advances have been achieved with small molecule CFTR modulators which partially increase the activity of certain CFTR mutants. However, ~10% of people with CF have nonsense mutations and/or splice defects which result in little to no CFTR …
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Clinical translation of optical coherence tomography for the diagnosis of otitis media: validation and tracking of biofilms on the tympanic membrane and development of a novel automated classification and diagnostic platform
… the assessment of OCT images of OM, with little translation of this technique outside of well-controlled academic-led studies. This dissertation establishes (1) the presence and characterization of biofilms adhered to the TM through direct observation, sampling, and analysis, (2) tympanostomy …
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Tackling the Bottlenecks in Translational Nanomedicine: Towards Precision in Size Control and Facile Nanoformulation
… Despite the immense research output, the translation of nanoparticle-based formulations into clinics has been limited. The efficient clinical translation of nanomedicine is impeded by several bottlenecks that include low targeting efficiency, imprecise size control, lack of scalable …
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A signal processing approach to ultrasound localization microscopy
… time and spatial resolution, which makes clinical translation challenging. In this thesis, in order to circumvent the trade-off, we pose the localization problem as a signal processing problem and introduce a filtering operation that is capable of separating microbubble contrast agents …
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Novel Optical Endoscopes for Early Cancer Diagnosis and Therapy
… optical endoscopic imaging techniques towards clinical translation. Before embarking on the development of novel devices, an analysis was made of the common challenges in translating optical imaging techniques. Through this work, a streamlined roadmap to clinical translation was developed, and …
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Tumor-penetrating delivery of small interfering RNA therapeutics
… and act on putative cancer targets. However, the translation of RNAi into the clinic has been thwarted by the "delivery" challenge, as small interfering RNA (siRNA) therapeutics must overcome clearance mechanisms and penetrate into tumor tissues to access cancer cells. This thesis sought to …
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