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Showing 1 to 7 of 7 for “"Chlorambucil"”.

  1. SENSITIZATION OF HUMAN COLON ADENOCARCINOMA CELLS TO CHLORAMBUCIL BY PLANT POLYPHENOLS

    ZHANG KAI1996

    nus Repository record

  2. N-[2-(Diethylamino)ethyl]benzamide als melanomaffine Trägermoleküle für Zytostatika und Gadoliniumkomplexe

    Wolf, MarkusUniversität Heidelberg

    … für Zytostatika ausgewählt. Es wurden Chlorambucilkon-jugate, Chlorambucilanaloga, Dacarbazinanaloga, Methotrexatkonjugate, ein Platinkomplex und ein Anthrazyklinkonjugat synthetisiert, analytisch charakterisiert und ihre IC50-Werte für murine B16 Melanomzellen, SkMel 28 (humane …

    heid-diss Repository record

  3. Die therapieabhängige Kinetik der Neubesiedlung des T-Zellkompartiments im peripheren Blut von Patienten mit rezidivierender chronischer lymphatischer Leukämie

    Maass, Catharina SophieChristian-Albrechts-Universität zu Kiel

    … Hierzu wurden Patienten der Therapiearme (Chlorambucil/Obinutuzumab vs. Venetoclax/Obinutuzumab) anhand prätherapeutischer Parameter und ihres Ansprechens kategorisiert und anschließend untersucht. CLL-Patienten zeigten ein deutlich reduziertes T-Zellrepertoire mit oligoklonalen …

    cau-kiel Repository record

  4. Using <i>Drosophila melanogaster</i> as a Whole-Model Animal System to Elucidate the Mechanism of Action of Novel Anticancer Agents

    Jones, Amy R.University of Cincinnati2012

    … to traditional DNA modifying agents: cisplatin, chlorambucil, and 5-fluorouracil. Results of injection with the common agents were consistent with the agents’ known mechanisms of action. However, a dramatic reduction in survival was seen for both <i>Sod1</i> knockdown mutants as well as …

    ohiolink Repository record

  5. Mechanistic investigation of anticancer agents that damage DNA and interact with the estrogen receptor

    Gopal, SreejaMassachusetts Institute of Technology2009

    … of E2-7ca compared to the control compound chlorambucil. E2-7ca induces cell death in SKOV-3 cells through autophagy, as opposed to the classical cell death pathway of apoptosis. Mechanistic studies on the role of ER in E2-7a toxicity in SKOV-3 cells show that the absence of the ER …

    mit Repository record

  6. In Vitro Studies of the Anti-Leukaemic Activity of Bezafibrate and Medroxyprogesterone Acetate Against Chronic Lymphocytic Leukaemia

    Hayden, Rachel ElizabethUniversity of Birmingham2010

    … effective as the commonly used chemotherapeutic chlorambucil, with the combination of all 3 agents exerting the greatest effects. However none of the combinations induced apoptosis of CLL cells protected by CD40L. Investigations into the possible mechanisms of drug action revealed that MPA was …

    birmingham Repository record

  7. ΣΥΝΘΕΣΗ ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΣΤΕΡΟΕΙΔΩΝ ΕΣΤΕΡΩΝ, ΜΕ ΠΑΡΑΓΩΓΑ ΤΗΣ Ν, Ν-ΔΙΣ(2-ΧΛΩΡΟΑΙΘΥΛ)ΑΝΙΛΙΝΗΣ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΔΡΑΣΗ ΑΥΤΩΝ

    Πάϊρας, ΓιώργοςUniversity of Patras1987

    THE COMPOUNDS HERE PREPARED ARE STEROIDAL ESTERS OF N,N-BIS (2- CHLOROETHYL)ANILI WITH SEVERAL OF THE STEROIDS MODIFIED TO THE A OR D LACTAMS BEFORE ESTERIFICATION. SIXTEEN COMPOUNDS WITH POSSIBLE CYTOSTATIC ACTIVITY WERE PREPARED BY TWODIFFERENT METHODS. THE ALHYLATING AGENTS USED WERE THE …

    greece Repository record