Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1624 for “"Cell cycle"”.
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Cardiomyocyte Cell Cycle, Renewal and Isolation
… strategy. In paper I, the focus is on the cellular growth patterns of murine cardiomyocytes under steady-state conditions. The turnover of cardiomyocytes was accurately established and key gene expression patterns associated with developmentally distinct periods of cardiomyocyte growth and …
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Cell Cycle Progression Effects of Albumin
<p>Progression through G<sub>1</sub> phase of the cell cycle is controlled largely by growth factors in early G<sub>1</sub> and by nutrients in late G<sub>1</sub> indicating sufficient raw material for cell division. We previously mapped a late G<sub>1</sub> cell cycle checkpoint for lipids …
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Circadian Control of Cell Cycle Progression
Tumorigenesis is the result of uncontrolled cell growth due to the deregulation of cell cycle checkpoints 1. Period 2 (Per2) is a tumor suppressor that oscillate in expression in a 24-hour cycle 2, 3. Here, we show that Per2 interacts with the tumor suppressor protein p53. Both G1 and G2 checkpoint …
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Mapping the cell cycle-dependent centrosomal interactome
… and precisely ordered events must occur for cells to multiply. Understanding the dynamic interactions of proteins driving this process are crucial for deciphering cell fate. The centrosome is a non-membrane-bound organelle that acts as the primary microtubule organizing centre and is believed …
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Visualization of the Budding Yeast Cell Cycle
The cell cycle of budding yeast is controlled by a complex chemically reacting network of a large group of species, including mRNAs and proteins. Many mathematical models have been proposed to unravel its molecular mechanism. However, it is hard for people with less training to visually interpret …
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The role of anchorage in cell cycle control
Mammalian cells generally require both mitogens and anchorage signals in order to proliferate. Failure to receive these signals results in either cell-cycle arrest or cell death, known as anoikis, due to activation of anchorage-dependent checkpoint mechanisms. Transformed cells alleviate these …
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Cell cycle perspectives on breast cancer cell behaviour
… important characteristics of aggressive tumour cells. Previous observations in both colorectal cancer and basal cell carcinoma indicated that infiltrative tumour cell behaviour might be counteracted by a high proliferative activity, suggesting a coordination of these two activities at the …
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Role of microRNA-host-lncRNAs in cell cycle
Made available in DSpace on 2020-08-27T00:46:52Z (GMT). No. of bitstreams: 2 SUN-DISSERTATION-2020.pdf: 9175277 bytes, checksum: e2efccee2ecdb753df410d65867ed198 (MD5) LICENSE.txt: 4206 bytes, checksum: d9400be8634f345516a8365c493c941a (MD5) Previous issue date: 2020-03-17
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Analysis of cell cycle surveillance mechanisms in meiosis
… hazard to the genomic integrity of the cell. Studies in a number of organisms have unveiled the existence of surveillance mechanisms or checkpoints that couple DNA repair and microtubule integrity to meiotic cell cycle progression. Through their action, aberrant meiocytes are delayed in …
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Cell cycle regulation during gametogenesis in budding yeast
… reproduction depends on meiosis, the specialized cell division that gives rise to gametes. During meiosis, two consecutive rounds of chromosome segregation follow one round of DNA replication to yield four haploid gametes from one diploid progenitor. In meiosis I, homologous chromosomes segregate …
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Coordination of origin licensing and cell cycle entry
… of the genome is a fundamental requirement for cellular propagation. To ensure successful transmission of genetic material to progeny, the preparation for, initiation, and completion of DNA replication are closely coordinated with cell growth. Central to this coordination is the regulated …
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Mathematical Modeling of the Budding Yeast Cell Cycle
The cell cycle of the budding yeast, Saccharomyces cerevisiae, is regulated by a complex network of chemical reactions controlling the activity of the cyclin-dependent kinases (CDKs), a family of protein kinases that drive the major events of the cell cycle. A previous mathematical model by Chen et …
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Proteomic Map of ER+ Breast Cancer Cell Cycle
Cancer is characterized by a deregulation of the cell cycle resulting in abnormal proliferation of cells that can bypass tightly regulated molecular checkpoints. Breast cancer is the most common cancer diagnosed in women, ~70% of cases displaying an estrogen receptor positive (ER+) phenotype. The …
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Expansion microscopy to visualize cell-cycle events in the abbreviated cell cycle in <i>Caenorhabditis elegans</i> (roundworm) germline stem cells
<p>The abbreviated cell cycle is a poorly understood form of the cell cycle essential for genome stability in stem cells. To visualize cell-cycle events in the abbreviated cell cycle, we optimized a protocol for expansion microscopy in stem cells of the reproductive system of the model organism C. …
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Cell Cycle Control by Cyclin-CDKS in Chlamydomonas Reinhardtii
<p>The cell cycle consists of a series of events, including replication and segregation of the genome, that occurs in order to ensure successful reproduction of cells. In fungi and animals, this process is carefully regulated by a set of protein complexes with alternating, oscillating activity. A …
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Mitochondrial inheritance and cell cycle regulation in Saccharomyces cerevisiae
… and other organelles are coordinated with cell cycle progression in the budding yeast, Saccharomyces cerevisiae. Recent studies have revealed a checkpoint that inhibits cytokinesis when there are severe defects in mitochondrial inheritance. An established checkpoint signaling pathway, the …
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The co-modulation of apoptosis and the cell cycle
… we have become increasingly reliant on mammalian cell culture for the production of biopharmaceuticals; therefore research aimed at improving the characteristics of the cell-lines being used for recombinant protein production is essential. In this study I have examined the hypothesis that the …
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The Effect of Mitochondrial Dynamics on Cell Cycle Progression
… segregation is the most critical event during cell cycle progression and appears to be precisely controlled by several defined machineries. On the other hand, the mechanisms by which cellular organelles duplicate and partition into two daughter cells during cell division have been barely …
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