Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 102 for “"Cell adhesion molecule"”.
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The Regulation of Bone Marrow Mesenchymal Stem Cells by Vascular Cell Adhesion Molecule-1
Bone marrow (BM) mesenchymal stem cells (MSCs) form specialized perivascular microenvironments or niches in the BM that regulate hematopoietic stem cell (HSC) function. Interactions between MSC niche factors and HSCs ensure hematopoietic homeostasis. Vascular Cell Adhesion Molecule-1 (VCAM1) is …
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Mechanism of the Neural Cell Adhesion Molecule and Mode of Polysialic Acid Adhesive Inhibition
… acid on both NCAM and C-cadherin mediated adhesion. Results indicate that polysialic acid inhibits both NCAM and cadherin adhesion by increasing the intermembrane repulsion. This inhibitory effect was dependant on both polysialic acid surface density and on ionic strength.
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Role of ICAM-1, a cell adhesion molecule, in morphological changes of BV2 microglial cell
Microglial cells, the major immune effector cells in the central nervous system, are activated in various brain injuries. Lipopolysaccharide (LPS), found in the outer membrane of Gram-negative bacteria, one of the major activator of microglia induces morphological changes and activation of the …
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Characterizing the Nuclear Function of the Cell Adhesion Molecule Fat and Chromatin Regulation by the Inner Nuclear Membrane Protein Speg
Tissue growth, pattern formation and cell metabolism are fundamental to animal development. Coordination of these aspects requires elegant signal transduction systems. In Drosophila, fat (ft) encodes an enormous atypical cadherin that is important for such coordination. Ft functions at the cell …
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Structure of the Chicken Neuron-Glia Cell Adhesion Molecule, Ng-CAM: Origin of the Polypeptides and Relation to the Ig Superfamily
<p>The neuron-glia cell adhesion molecule, Ng-CAM, is a cell-surface glycoprotein expressed on neurons and Schwann cells in the chicken nervous system. It is expressed as a group of related components of ~200 kD, 135 kD, and 80 kD, which are detected at particular sites during development. Ng-CAM …
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The neural cell adhesion molecule 2 (NCAM2) promotes excitatory synapse formation through increasing insulin and insulin-like growth factor 1 receptor signaling
Deletions in the gene coding for the neural cell adhesion molecule 2 (NCAM2) have been found in patients with intellectual disability. Growing evidence indicates that deficits in synaptogenesis and impaired signaling mediated by the insulin receptor and insulin-like growth factor 1 (IGF1) receptors …
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Probing Biological Systems at the Single Molecule Level: Studies of the Homophilic Binding of the Neural Cell Adhesion Molecule (Ncam) and Phase Dependent Lipid Anchorage Strength
… probed to determine how temperature affects the adhesion properties between adjacent lipid molecules. From this study we have shown that it takes almost three times the force to extract a lipid from a gel phase lipid layer as opposed a fluid phase layer.
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THE ROLE OF SDF-1[alpha] AS A VASCULOGENIC CHEMOKINE AND ENDOTHELIUM-ASSOCIATED CELL ADHESION MOLECULE FOR THE RECRUITMENT OF BONE MARROW-DERIVED PROGENITOR CELLS TO DEVELOPING TUMORS
… for lymphocytes, hematopoietic progenitor cells, and vascular endothelial cells. SDF-1 alpha binds to the CXCR4 receptor on cell surfaces and to heparan sulfate in cell membranes and the extracellular matrix. We hypothesized that SDF-1 alpha is an important mediator of tumor vasculogenesis, …
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Structural and Dynamic Proximal Proteomic Analysis of TRPV2 Ion Channel Activation
… regulated pathway which mediates every vital cellular function through the propagation of localized calcium flux. Transient receptor potential vanilloid type 2 (TRPV2) ion channels are calcium-permeable, tetrameric ion channels with implications in several cellular processes such as immune …
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Metabolism in Vascular Endothelial Cells: Effects of Hyperglycaemia, Pro-Inflammatory Cytokines and Polyphenols
… vascular endothelium by modulating endothelial cell metabolism. Results: First, the effects of high-glucose concentrations, inflammatory cytokines and polyphenols on markers of endothelial cell function in HUVECs were explored. Hyperglycaemic conditions did not significantly affect cell …
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ROLE OF ACID SPHINGOMYELINASE IN ICAM-1/NHE1-DEPENDENT ENDOCYTOSIS: IMPLICATIONS IN LEUKOCYTE TRANSMIGRATION
Engagement of intercellular adhesion molecule-1 (ICAM-1) on endothelial cells (ECs) by anti-ICAM coated beads generates vesiculization via cell adhesion molecule (CAM)-mediated endocytosis, a clathrin-/caveolae-independent pathway involving Na+/H+ exchanger 1 (NHE1). ICAM-1 itself plays a key role …
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Effects of Cadmium on VCAM-1 Expression
… 뇌혈관 내피세포인 bEnd.3에서 카드뮴을 처리했을 때 그로 인해 변화되는 부착분자 (adhesion molecule)의 발현이 어떠한 신호전달로 매개되는지를 알아보기 위하여, 카드뮴을 처리한 후 Vascular cell adhesion molecule-1 (VCAM-1)의 변화와 Mitogen Activated Protein Kinase (MAPK) 저해제들이 VCAM-1의 변화에 미치는 효과를 관찰하였다. 그 결과, 카드뮴 처리 2시간째 VCAM-1 mRNA의 발현이 증가하였고 카드뮴 처리 4시간째에 VCAM-1 단백질 …
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Kasos adenokarcinomos diagnostinių ir prognostinių biožymenų paieška /
… spectrometry. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) was discovered as a possible promising pancreatic cancer biomarker. The predominance of CEACAM6 to pancreatic cancer was validated using antibodies in tissue samples. CEACAM6, carbohydrate antigen 19-9 (CA19-9), …
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Development of 3-d liver model for drug screening applications
… electrospinning technique. In order to promote cell adhesion on the chitosan scaffolds, the scaffolds were coated with a cell adhesion molecule, fibronectin, by adsorption. The effects of mono-culture and co-culture systems on the proliferation and functional activities of hepatocytes were …
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Regulation of Oligodendrocyte differentiation through Neuroligin-Neurexin signalling
… in neurons by virtue of its role as a synaptic cell adhesion molecule, and because mutations in the gene have been associated with Autism Spectrum Disorder (ASD). However much less is known about its role in the glial cell population, where one of the subtypes, neuroligin 3, is expressed. The …
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Roles For B-Raf Kinase In The Specific Regulation of Α4Β1 Integrin In T Cells
<p>The regulation of integrin-mediated adhesion is of vital importance to adaptive and innate immunity. Integrins are versatile proteins and mediate T cell migration and trafficking by binding to ECM or other cells, as well as initiating intracellular signaling cascades promoting survival or …
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Vitamin C status, oxidative stress, hyperglycaemia and endothelial function in critically ill patients with septic shock : an observational study
… of oxidative stress - and soluble vascular cell adhesion molecule-1 (sVCAM-1), and E-selectin, as markers of endothelial dysfunction. The plasma glucose to vitamin C ratios were also calculated. Daily clinical measures in the patients included Sequential Organ Failure Assessment (SOFA) …
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MAdCAM-1 expression and function in human liver
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is a tissue–specific protein that promotes α4β7+ lymphocyte recruitment on gut mucosal endothelium, playing an important role in the development of inflammatory bowel disease (IBD). Recent studies have reported its expression in liver diseases …
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