Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"Cell Tracking"”.
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Large-area cell-tracking cytometry for biophysical measurements of single cells
Utility of single-cell biophysical markers is often limited due to the low-specificity nature of biophysical markers and lack of existing techniques which can test multiple biophysical characteristics for single cells. To address this challenge, I developed a multiparameter intrinsic cytometry …
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Automatic Cell Tracking For Studying Large Epithelial Sheets Of Cells And Its Application To Chicken Gastrulation
… vortical flows that involve an order of >200,000 cells. During this self-organised process individual epithelial cells are migrating in a highly coordinated manner. The cell behaviours driving the flows and migration are unknown due to the lack of high resolution time lapse sequences showing each …
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Lab on a chip rare cell isolation platform with dielectrophoretic smart sample focusing, automated whole cell tracking analysis script, and a bioinspired on-chip electroactive polymer micropump
… Contactless DEP (cDEP) is a recently developed cell sorting and isolation technique that uses the DEP force by capacitavely coupling the electrodes across the channel. The cDEP platform sorts cells based on intrinsic biophysical properties, is inexpensive, maintains a sterile environment by …
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Detection and Quantification of Cells using Magnetic Particle Imaging and Magnetic Microspheres
… nanoparticles (SPIOs). Our lab has shown that cell tracking with magnetic resonance imaging (MRI) has very high sensitivity, but low specificity and quantification of iron labeled cells is difficult. MPI cell tracking could overcome these limitations. A MomentumTM MPI system was installed at …
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The dynamics of anti-tumour responses generated by chimeric antigen receptor-modified immune effector cells
A patient’s own T cells can be genetically modified and amplified in the laboratory to target antigens expressed on tumour cells through the introduction of chimeric antigen receptor (CAR) genes. Despite considerable advances in the treatment of B cell leukaemia using chimeric antigen receptor T …
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Computational Techniques for Advancing Photoacoustic Microscopy
… Additionally, a spatiotemporal red blood cell tracking algorithm, together with a high-speed PAM system, is developed to mitigate resolution anisotropy, providing super-resolved structural and functional images of the 3D microvasculature. Furthermore, a new analytical approach is developed …
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Electromagnetic nanopositioner
… interferometry, nanofabrication, vibration cancellation, biological cell tracking/positioning, and beam focusing/steering. The nanometer-resolution positioning required in these applications is often provided using piezoelectric ceramic actuators. The drawbacks to using piezoelectric actuators …
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Effects of substrate stiffness on bacterial biofilm formation
<p>Biofilms are communities of microbial cells attached on surfaces and embedded in a self-produced extracellular matrix comprised of polysaccharides, DNA, and proteins. Biofilms of pathogenic bacteria cause serious chronic infections due to high tolerance to antibiotics and host immune systems …
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Cellular tracking and mitosis detection in dense in-vitro cellular data
Cell migration and cell division are two key processes that are associated with a wide range of biological phenomena including embryogenesis, inflammation, wound healing, tumour development etc. The study of these cellular processes has received a substantial interest from the cell and molecular …
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Cell Migration and Morphogenesis during Formation and Repair of Zebrafish Skeletal Muscle
… to somite shape morphogenesis. In vivo cell tracking revealed that cellular dynamics during somite morphogenesis constitute a potential force, capable of driving somite shape changes. Tracked anterior border cells (abc) were observed migrating to the lateral somite surface were they are …
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The evolution of somitogenesis: Mechanisms of paraxial mesoderm elongation in zebrafish and other vertebrates
… a novel mechanism of “compression-extension”. Cell tracking, agent-based modelling, and perturbations show that this form of convergent extension does not involve PCP-dependent directional intercalation but, instead, involves convergent flows of cells towards the midline and non-directional …
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Automated Tracking of Mouse Embryogenesis from Large-scale Fluorescence Microscopy Data
… the recording of mouse embryogenesis at the cellular level for days, easily generating terabyte-level 3D time-lapse data. Since millions of cells are involved, this information-rich data brings a natural demand for an automated tool for its comprehensive analysis. This tool should …
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Taste Learning in Insular Cortex: Plasticity Is Influenced by Experience Type
… of cortical taste coding on a single-cell level has only become clear in recent years. The anatomical location of GC on the lateral and ventral surface of the brain makes it difficult to target with traditional imaging methods. Thus, much of what we know about cortical taste coding and …
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Characterisation of Androgen Receptor Variants in Breast Cancer and the Development of Thieno[2,3-b] Pyridines as Novel Anti-Cancer Compounds
… flow-cytometry analysis, florescent imaging and cell tracking assays it was demonstrated that the compounds are potent inhibitors of PCa proliferation and motility. Importantly,the drugs were found to induce multi-nucleation, G2/M arrest and promote apoptosis. Further, a drug pull-down assay …
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Development of 89Zirconium-PET Tracers for Immune Cell Imaging
The use of cell-based therapies as a living drug have gained considerable attention for the treatment of a range of conditions such as genetic diseases, autoimmune disorders and cancer. The emergence of genetically engineered T cells expressing chimeric antigen receptors (CAR T-cells), together …
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