Global ETD Search
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Showing 1 to 5 of 5 for “"Celastrol"”.
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Celastrol induces paraptosis-like cell death via mitochondrial Ca2+ overload in breast cancer cells
… yet fully understood. Recently, we found that celastrol, a triterpene extracted from the Chinese “Thunder of God Vine”, induced paraptosis accompanied by dilation of mitochondria and the ER in MDA-MB 435S and MCF-7 breast cancer cells. Inhibition of protein synthesis by cycloheximide blocked …
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Studies toward the synthesis of celastrol and the late-stage hydroxylation of arenes mediated by 4,5-dichlorophthaloyl peroxide
The natural product celastrol (1) possesses a wide array of promising biological activities related to diseases characterized by protein misfolding including those associated with neuronal degradation, inflammation, and cancer. Relevant to cancer, celastrol functions as a non-ATP-competitive …
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Overcoming Tumor Drug Resistance By Activating Amp-Activated Protein Kinase And Destabilizing Oncoproteins
… level. In my study, I examined the effect of celastrol, a natural product with potent proteasome inhibitory activity, on destabilizing Bcr-Abl protein, and explored the potential combination therapies for Bcr-Abl-driven leukemia. I found that (i) celastrol induced apoptosis and Bcr-Abl …
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Untersuchungen zur Regulation der humanen Xylosyltransferase-I bei Fibrosen
… the two active ingredients ampho¬tericin B and celastrol were identified to possess XT-I inhibitory properties. Their XT-I inhibi¬tory effect was not restricted to the inhibition of the catalytic activity of the XT-I protein by an uncompetitive or a competitive inhibition mode, respectively, but …
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Regulation of The Heat Shock Response By Thiol-Reactive Compounds In The Yeast Saccharomyces Cerevisiae
… insensitive to Hsf1 activation by cadmium and celastrol but not by heat shock. Conversely, substitution with the sulfinic acid and steric bulk mimic aspartic acid led to constitutive activation of Hsf1. Cysteine 303, located in the nucleotide-binding/ATPase domain of Ssa1, was shown to be …