Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Captopril"”.
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Revealing the Mechanism Underlying the Beneficial Effects of Angiotensin-Converting Enzyme Inhibitors in a Drosophila Alzheimer’s Disease Model
… transgene, Aβ42. We have previously shown that captopril, an ACE-I, reduced levels of brain cell death and rescued memory deficits in these flies. Furthermore, we demonstrated that a null mutation in acer, a homolog of ace, is sufficient to recapitulate these effects suggesting that Acer is the …
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Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models
… an ARB, attenuated the aortic dilation, but captopril, an ACEi, did not decrease aortic growth and worsened the disease. Transverse aortic constriction (TAC) was used to study the ascending aorta and aortic root in response to increased biomechanical forces. Losartan attenuated the histologic …
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Myocardial fibrosis and pathological hypertrophy in the rat with aorta-constricted hypertension
… hypertensive rats were treated with oral captopril or hydralazine. Captopril treatment prevented the development of hypertension, myocardial hypertrophy and fibrosis. Hydralazine treatment, although it reduced the blood pressure, did not prevent myocardial hypertrophy or fibrosis. This …
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Modelado de materiales para el soporte de medicamentos combinados
… cardiovasculares de uso extendido: aspirina, captopril e hidroclorotiazida. Se emplean cálculos basados en la Teoría del Funcional de la Densidad (DFT) para investigar las interacciones a nivel atómico. Se analizan las características estructurales y las propiedades electrónicas, como las …
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Manipulating the mechanical strength and biological stability of collagen-based scaffolds for tissue engineering
… investigate the potential of the ACE inhibitors captopril and enalapril to inhibit enzymatic collagen degradation, and ultimately slow down the rate at which collagen is degraded by cells of the body. Both captopril and enalapril were shown to inhibit enzymatic collagen degradation in a …
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Inhibitoren des Angiotensin Converting Enzyme (ACE) in hypoallergenen Säuglingsnahrungen
… (Gruppe 2) bzw. der bekannte ACE-Inhibitor Captopril (Gruppe 3) zugesetzt war, gefüttert. Eine vierte Gruppe mit Standardfutter diente als Kontrolle. Der Blutdruck wurde am wachen Tier nichtinvasiv mittels tail-cuff-Methode gemessen. Der systolische Blutdruck sank bei Verabreichung der …
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Magnetic resonance imaging studies of cardiac changes in diabetic and hypertensive rats
… of the angiotensin-converting enzyme inhibitor captopril upon such changes were also investigated. Finally, the MRI methods were also used to characterize the corresponding right ventricular changes in the spontaneously hypertensive rats (SHR), also for the first time. The MRI studies of the …
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Rat angiotensin-converting enzyme : tissue specific expression during pharmacological inhibition
… release of aldosterone. ACE inhibitors, such as captopril, enalapril and lisinopril, are highly effective in the treatment of hypertension and congestive cardiac failure. Previous studies have suggested that angiotensin converting enzyme (ACE) production may be enhanced during pharmacological …
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Gene regulation and hypertroipc responses in age-matched control and STZ-treated rats
… the pharmacological effect of either digoxin or captopril, at a dose of 10 3 M, on the force of contraction of isolated healthy age-matched control intact perfused hearts. The results show that the cardiac glycoside, digoxin evoked a small increase in the force of contraction of the heart, whilst …
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Aspects of the interrelation between hypertension and insulin resistance: A preliminary study
… hypertension and if so. to determine whether captopril will affect the presence of insulin resistance. This model should in future be used to study vascular reactivity to phenylephrine (PHE), acetylcholinc (AC!-1) and sodium ni troprusside (S~P) in hypertensive animals in the absence or …
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Effects of ovokinin on isolated aortas of guinea pigs, normotensive and spontaneously hypertensive rats
… was blocked when rings were pretreated with captopril, a kininase II inhibitor. Ovokinin may also exhibit slight vasorelaxing activity in spontaneously hypertensive rat aortas precontracted with prostaglandin F2a. These findings suggest that, like bradykinin, the effects of ovokinin are …
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Characterisation of the pharmacological actions in humans of multiple vasoactive enzyme inhibitors with therapeutic potential in heart failure
… KC 12615, phosphoramidon (NEP/ECE inhibitor), captopril (ACE inhibitor), and thiorphan (NEP inhibitor). Of note the augmentation is no greater with omapatrilat than captopril and in arteries taken from patients prescribed ACE inhibitor, KC 12615 does not augment the response. The vasodilator …
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Renale Effekte von Angiotensin I und seinen Metaboliten bei experimenteller Hypertonie
… gesteigerte Noradrenalinfreisetzung in WKY. Captopril verschob die DWK’s von Ang I und des-Asp-Ang I im selben Maße nach rechts. Ang 1-7 verschob die DWK’s der renalen Druckantwort und induzierten Noradrenalinfreisetzung von Ang I und Ang II kompetitiv nach rechts. Eine Beteiligung des Ang …
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Investigating the role of the Renin Angiotensin System in cancer
… cells. Treatment with the ACE-1 inhibitors, Captopril and Lisinopril, reduced this activity. We showed that ACE-1 axis stimulation in cancer cells results in increased calcium signaling preferentially via the AT1R and this associates with cancer cell proliferation. Candesartan, an AT1R …
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Étude comparative des effets hypotenseurs de la bradykinine et de l'hémopressine chez le lapin, le rat et la souris
… réponse à l'HP n'était pas potentialisée par le captopril (100 [micro]g/kg). Cela suggère que, contrairement à la BK, l'HP n'est pas susceptible à l'inactivation cardiaque/pulmonaire. Le prétraitement des lapins avec le HOE 140, un antagoniste spécifique du récepteur B[indice inférieur 2] des …
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Establishing models of and characterising the genomic context of neutrophil hypersegmentation
… angiotensin converting enzyme inhibitor (ACEi) captopril, glucose concentration, and hypoxia. Furthermore, the current work outlines the optimisation of a laser capture microdissection (LCM) technique for the isolation of neutrophils, based on their morphologic phenotype, to permit RNA …
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Metallo-β-lactamase-like enzymes from non-pathogenic organisms: an illustration of functional promiscuity
… also inhibited by the non-clinical compound D-captopril in a manner characteristic for MBLs. Thus, even though MIM-1 and MIM-2 are currently not associated with antibiotic resistance these enzymes, should they ever enter the human population, certainly could pose a future threat to health care. …