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Showing 1 to 20 of 68 for “"Capsaicin"”.
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Chlorid-basierte Signalverstärkung in Capsaicin-sensitiven Schmerzzellen
… Hin-weise erarbeitet, dass TRPV1-exprimierende, Capsaicin-sensitive Schmerzzellen den Cl--basierten Mechanismus zur Verstärkung sensorischer Signale verwenden. In Ganzzell-Ab-leitungen wurden Capsaicin-induzierte, exzitatorische Cl--Ströme mit stark variierenden Amplituden gemessen, die die …
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Critical role of ROS in capsaicin-induced hyperalgesia
… on pain behaviors were examined in mice. The capsaicin-induced hyperalgesia was used as a pain model since it has 2 distinctive pain components, primary and secondary hyperalgesia representing peripheral and central sensitization, respectively. Foot withdrawal frequencies in response to von …
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Mouse Embryo Development in the Presence of Capsaicin
<p>Capsaicin is the pungent agent found in hot peppers of the Capsicum genus. It is a potent neurotoxin that stimulates the degranulation and degeneration of C-afferent neurons. Capsaicin is widely used as a food condiment and medicine. Human exposure of capsaicin can exceed levels shown to be …
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Molecular Study of Capsaicin in Aqueous and Hydrophobic Environments
… foods has experienced the adverse effects of capsaicin, the pungent chemical found in hot chili that causes a burning sensation. The specific action of capsaicin occurs by the activation of receptors in sensory neurons. This thesis investigates the interaction of capsaicin with model cell …
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Regulation der Capsaicin-Sensitivität von murinen Spinalganglienzellen durch neurotrophe Faktoren
… herausgearbeitet werden, dass die Regulation der Capsaicin-Sensitivität in der Maus von vielen Faktoren abhängig ist: Es ließ sich ein komplexes System der Regulation von Capsaicin-induziertem Cobalt-Uptake als Surrogat-Marker für nozizeptive Neurone herausarbeiten: Zum einen konnte gezeigt …
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Extraction of Capsaicin Using the Polyol Induced Extraction (PIE) Method
… PIE process may be used to separate caffeine and capsaicin. When acetonitrile and water are used as a 1:1 solvent mixture, two immiscible phases are created upon addition of the polyol, glycerol. Initially, for purposes of training on the PIE method, the studies primarly began with the extraction …
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Capsaicin-sensitive area in the ventral surface of the rat medulla
Capsaicin sensitive structures were found near the ventral surface of the medulla, at the exit of hypoglossal nerve roots in acute experiments on rats. Injection of 5-50 nl 0.01% capsaicin to the rostral region of the capsaicin-sensitive area was accompanied by the increase of arterial pressure and …
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Effect of Capsaicin Supplementation on Performance of and Physiological Response to Repeated Sprinting
… this study was to investigate the influence of capsaicin on performance of and the physiological response to an exercise test simulating the fitness demands of team sport game conditions. Methods: This study was a placebo-controlled, crossover design. Nineteen healthy male experienced athletes …
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Comparison of Prophylactic or Therapeutic Dietary Administration of Capsaicin Oleoresin for Resistance to Salmonella in Broiler Chickens
… (P < 0.05) L/S and ceca positives. In Expt. 2, capsaicin oleoresin (CO) was included in finisher diets (d 30-37) at 0, 5, or 20 ppm with SE challenge on day 31. Inclusion of 5 ppm CO increased (P < 0.05) ceca SE positives and demonstrated 1.05 and 1.39-log fewer SE cfu at CO concentration of 5 …
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Synergistic anti-cancer effects of capsaicin and 3,3'-diindolylmethane in human colorectal cancer, involvement of p53 and NF-kB
… we evaluated potential synergistic effects of capsaicin, an active compound from red chili peppers, in combination with 3,3'-Diindolylmethane (DIM), from cruciferous vegetables. A synergistic induction of apoptosis and inhibition of cell proliferation was observed in multiple cancer cell lines …
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Modulation of synaptic transmission by TRP channels
… I determined if recordings that respond to capsaicin demonstrate synaptic plasticity in either hippocampus or spinal cord, in an attempt to attribute synaptic plasticity mechanisms to TRPV1 activity at glutamatergic terminals. I have used slice patch-clamp technique to record miniature, …
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Neurally Released Nitric Oxide does not Oppose Reflex Cholinergic Contraction of Airway Smooth Muscle in Dogs
… saline (1ml, into a lobar bronchus) and capsaicin (injected into right atrium).|The first part of our study demonstrated that changes in airway resistance to hypertonic saline and capsaicin are neurally mediated. We compared changes in airway resistance to hypertonic saline and capsaicin …
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Studies of Capsaicinoids Contents of Locally Grown and Commercial Chilies Using Reversed-Phase High Performance Liquid Chromatography.
<p>Capsaicinoids are a class of compounds responsible for the "heat" of hot peppers. Capsaicin and dihydrocapsaicin have the highest burning effect. The aim of this work is to separate and quantify the two major capsaicinoids in fruits harvested at different stages of development and at different …
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The effectiveness and relative effectiveness of combining a topical capsaicin cream and knee joint mobilization in the treatment of osteoarthritis of the knee
A dissertation submitted in partial compliance with the requirements for the Masters Degree in Technology: Chiropractic, Durban University of Technology, Durban, South Africa, 2002.
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Effect of Intranasal Delivery of Carbon Dioxide on Trigeminal Ganglion Neurons: Inhibition of Neuron-Glia Gap Junction Communication and Neuropeptide Secretion
… and satellite glial cells was seen 2 hrs after capsaicin injection into the whisker pad. This gap junction communication was greatly reduced in animals treated with CO2 prior to capsaicin stimulation. CO2 treatment also blocked the stimulatory effect of capsaicin on Cx 26, S100B and CGRP …
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Targeting pro-inflammatory mediators to treat visceral pain
… of which also responded to the TRPV1 agonist capsaicin, thus indicating that these neurons were nociceptors. TNFα levels correlate with pain in IBD and IBS, and TNFα is known to sensitise colonic sensory neurons. Somatic, TNFα-triggered thermal and mechanical hypersensitivity is mediated by …
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Development and Applications of Opioids Alternatives for Pain Management
… to opioids, focusing on tetrodotoxin (TTX) and capsaicin as novel anesthetics. Acute post-surgical pain typically lasts 5-7 days, while long-term pain management can span up to 12 weeks. Opioids are commonly used but are linked to serious side effects, including addiction, nausea, cognitive …
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